Heptafluorobutyric acid Property

Melting point:

-17.5 °C

Boiling point:

120 °C755 mm Hg(lit.)

Density 

1.645 g/mL at 25 °C(lit.)

vapor density 

7 (vs air)

vapor pressure 

~10 mm Hg ( 25 °C)

refractive index 

n20/D 1.3(lit.)

Flash point:

120-121°C

storage temp. 

Store below +30°C.

solubility 

Chloroform: soluble; Methanol: soluble

form 

Powder

pka

pK1:0.17 (25°C)

Specific Gravity

approximate 1.6

color 

Clear colorless to faint yellow

PH

1 (H2O, 20℃)

Water Solubility 

miscible

Sensitive 

Light Sensitive

BRN 

1426882

InChIKey

YPJUNDFVDDCYIH-UHFFFAOYSA-N

CAS DataBase Reference

375-22-4(CAS DataBase Reference)

NIST Chemistry Reference

Butanoic acid, heptafluoro-(375-22-4)

EPA Substance Registry System

Heptafluorobutyric acid (375-22-4)

Safety

Hazard Codes 

C

Risk Statements 

34-35

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

ET4025000

F 

3-8-10

Hazard Note 

Corrosive

TSCA 

T

HazardClass 

8

PackingGroup 

II

HS Code 

29159000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

Heptafluorobutyric acid Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to faintly yellow liquid

Uses

Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.

Uses

Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.

Uses

Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.

Definition

ChEBI: A monocarboxylic acid that is perfluorinated butyric acid.

General Description

Perfluorobutyric acid is an effective additive for zinc electrodeposition.

Hazard

Irritant to tissue.

Purification Methods

Fractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]