3-Chloro-4-methylaniline
- Product Name
- 3-Chloro-4-methylaniline
- CAS No.
- 95-74-9
- Chemical Name
- 3-Chloro-4-methylaniline
- Synonyms
- CPT;2-CHLORO-4-TOLUIDINE;3-CHLORO-4-METHYL-PHENYLAMINE;OCPT;3-cpt;cpt[qr];drc1347;2B oil;DKC 1347;DRC 1339
- CBNumber
- CB5854707
- Molecular Formula
- C7H8ClN
- Formula Weight
- 141.6
- MOL File
- 95-74-9.mol
3-Chloro-4-methylaniline Property
- Melting point:
- 25 °C
- Boiling point:
- 237-238 °C(lit.)
- Density
- 1.17
- vapor pressure
- 4.973-8.666Pa at 25℃
- refractive index
- n20/D 1.584(lit.)
- Flash point:
- 212 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol (Slightly)
- form
- powder to lump to clear liquid
- pka
- pK1: 4.05(+1) (25°C)
- color
- White or Colorless to Light orange to Yellow
- Specific Gravity
- 1.167
- Water Solubility
- 1 g/L (20 ºC)
- BRN
- 636511
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acids, acid anhydrides, chloroformates, reducing agents.
- LogP
- 2.27
- CAS DataBase Reference
- 95-74-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenamine, 3-chloro-4-methyl-(95-74-9)
- EPA Substance Registry System
- 3-Chloro-4-methylaniline (95-74-9)
Safety
- Hazard Codes
- T,N,Xn
- Risk Statements
- 24/25-36/38-43-50/53-36/37/38-22
- Safety Statements
- 36/37/39-45-61-60-36/37-26
- RIDADR
- UN 2239 6.1/PG 3
- WGK Germany
- 2
- RTECS
- XU5111000
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214300
- Hazardous Substances Data
- 95-74-9(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 236322
- Product name
- 2-Chloro-4-aminotoluene
- Purity
- 98%
- Packaging
- 50g
- Price
- $45.03
- Updated
- 2025/07/31
- Product number
- C0538
- Product name
- 3-Chloro-4-methylaniline
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- C0538
- Product name
- 3-Chloro-4-methylaniline
- Purity
- >97.0%(GC)
- Packaging
- 500g
- Price
- $559
- Updated
- 2025/07/31
- Product number
- C587865
- Product name
- 3-Chloro-4-methylaniline
- Packaging
- 50g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC64322
- Product name
- 3-Chloro-4-methylaniline
- Packaging
- 1kg
- Price
- $520
- Updated
- 2021/12/16
3-Chloro-4-methylaniline Chemical Properties,Usage,Production
Chemical Properties
brown solid
Chemical Properties
The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.
Uses
2-Chloro-4-aminotoluene has been used in the preparation of 2-chloro-4-cyanotoluene by Sandmeyer reaction with cuprous cyanide.
Definition
ChEBI: A monochloroaniline that is p-toluidine in which one of the hydrogens that is meta to the amino group is replaced by a chlorine.
General Description
Brown solid with a mild odor.
Air & Water Reactions
May be sensitive to prolonged exposure to air and light. Insoluble in water.
Reactivity Profile
3-Chloro-4-methylaniline may be sensitive to prolonged exposure to air and light. 3-Chloro-4-methylaniline may react with oxidizing agents. 3-Chloro-4-methylaniline is incompatible with acids, acid chlorides, acid anhydrides and chloroformates. 3-Chloro-4-methylaniline is also incompatible with reducing agents.
Fire Hazard
3-Chloro-4-methylaniline is combustible.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl and NOx. See also other chloro toluidme entries.
Synthesis
121-86-8
95-74-9
General procedure for the synthesis of 3-chloro-p-toluidine from 2-chloro-4-nitrotoluene: General method: Nitro compounds (1 eq.), hexafluoroisopropanol (HFIP, 10 eq.) and iron powder (5 eq.) were added to the reaction tube and mixed. Subsequently, a 2N aqueous hydrochloric acid solution was slowly added to the reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes and then neutralized with saturated aqueous sodium bicarbonate (NaHCO3) solution. Next, it was extracted three times with saturated aqueous sodium bicarbonate solution. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Finally, the crude product was purified by silica gel column chromatography to obtain the target product 3-chloro-p-toluidine.
Potential Exposure
Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.
Shipping
UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials
Incompatibilities
Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.
References
[1] Journal of the American Chemical Society, 2017, vol. 139, # 47, p. 17089 - 17097
[2] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3646 - 3649
[3] Chemische Berichte, 1884, vol. 17, p. 534
[4] Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 98,109
[5] Chem. Zentralbl., 1910, vol. 81, # I, p. 260
3-Chloro-4-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloro-4-methylaniline manufacturers
- Product
- 3-Chloro-4-methylaniline 95-74-9
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-20
- Product
- 3-Chloro-4-methylaniline 95-74-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30