Tacedinaline

Product Name: Tacedinaline
CAS No.: 112522-64-2
Chemical Name: Tacedinaline
Synonyms: acetyldinaline;CI 994;CS-617;Cl-994;Goe 5549;PD 123654;Tacedinaline;CI994, >=99%;N-Acetyldinaline;CI994 (Tacedinaline)
CBNumber: CB5855542
Molecular Formula: C15H15N3O2
Formula Weight: 269.3
MOL File: 112522-64-2.mol

More

Less

Tacedinaline Property

Melting point:: 216.1 °C
Boiling point:: 450.6±30.0 °C(Predicted)
Density: 1.322±0.06 g/cm3(Predicted)
RTECS: CU8702023
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in DMSO
pka: 13.15±0.70(Predicted)
form: powder
color: off-white
Sensitive: Air Sensitive
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: VAZAPHZUAVEOMC-UHFFFAOYSA-N

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2924.29.7790

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0621
Product name: CI 994
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $128
Updated: 2024/03/01

Sigma-Aldrich

Product number: C0621
Product name: CI 994
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $492
Updated: 2024/03/01

TCI Chemical

Product number: A2501
Product name: 4-Acetamido-N-(2-aminophenyl)benzamide
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $66
Updated: 2024/03/01

TCI Chemical

Product number: A2501
Product name: 4-Acetamido-N-(2-aminophenyl)benzamide
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $225
Updated: 2024/03/01

Alfa Aesar

Product number: J65561
Product name: CI 994
Packaging: 25mg
Price: $108
Updated: 2021/12/16

More

Less

Tacedinaline Chemical Properties,Usage,Production

Description

CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo.2,3 Increases neuroplasticity during memory extinction.4 Protects beta cells from cytokine-induced apoptosis.4

Uses

Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tumor cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.

Definition

ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.

Biological Activity

Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .

target

HDAC1

storage

+4°C

References

1) Moradei et al. (2007), Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity; J. Med. Chem., 50 5543 2) Beckers et al. (2007), Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group; Int. J. Cancer, 121 1138 3) Loprevite et al. (2005), In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines; Oncol. Res., 15 39 4) Chou et al. (2012), Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis; Chem. Biol., 19 669

Tacedinaline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Tacedinaline Suppliers

Americas 1 Canada 1 China 154 Europe 1 India 5 Japan 1 United Kingdom 4 United States 32 Global 199

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

LC Laboratories

Tel: --
Fax: --
Email: custserv@lclabs.com
Country: United States
ProdList: 503
Advantage: 50

Focus Biomolecules

Tel: --
Fax: --
Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Abcam

Tel: --
Fax: --
Email: us.orders@abcam.com
Country: United States
ProdList: 6000
Advantage: 50

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Kare Bay Biochem Inc.

Tel: --
Fax: --
Email: product@karebaybio.com
Country: United States
ProdList: 110
Advantage: 58

Selleck Chemicals LLC

Tel: --
Fax: --
Email: sales@selleckchem.com
Country: United States
ProdList: 1848
Advantage: 58

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

Exlcusive Chemistry Ltd

Tel: --
Fax: --
Country: United States
ProdList: 446
Advantage: 71

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

More

Less

View Lastest Price from Tacedinaline manufacturers

Career Henan Chemical Co

Product: Tacedinaline 112522-64-2
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

112522-64-2, TacedinalineRelated Search:

Benzamide p-Aminobenzamide Anthranilamide Acetaminophen Panobinostat PCI 34051 Mocetinostat (MGCD0103) Vorinostat Entinostat RGFP966 Dinalin N-{4-[(methylamino)methyl]phenyl}acetamide ACETAMINOPHENOL BP/USP Tacedinaline AURORA 8656 AURORA 8835

Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-

acetyldinaline

Tacedinaline

CI 994

N-Acetyldinaline

4-AcetaMido-N-(2-aMinophenyl)benzaMide

Cl-994(Tacedinalin,N-Acetyldinalin)

CI994 (Tacedinaline)

CI-994 4-Acetylamino-N-(2'-aminophenyl)benzamide

Goe 5549

PD 123654

CI994, >=99%

CI 994 - PD 123654 | Tacedinaline

-aminophenyl)benzamide

PD-123654;CI-994;PD123654

CS-617

Cl-994

CI-994 (Acetyldinaline,PD123654)

4-acetylamino-n-(2'-aminophenyl)benzamide

4-Acetamido-N-(2-aminophenyl)benzamide &gt

Tacedinaline (CI994)

Tacedinaline USP/EP/BP

Tacedinaline (GOE-5549, PD-123654, CI-994

Goe5549,CI-994,Tacedinaline,inhibit,HDAC,CI 994,Inhibitor,Histone deacetylases,Apoptosis,Goe 5549

CI-994, HDAC inhibitor. Cell-permeable.

112522-64-2

Inhibitors

Inhibitor

Apoptosis Inducers