Hydroxymethyl-7-Aminocephalosporanic acid

Product Name: Hydroxymethyl-7-Aminocephalosporanic acid
CAS No.: 15690-38-7
Chemical Name: Hydroxymethyl-7-Aminocephalosporanic acid
Synonyms: D-7-ACA;DACA;HACA;(6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Cephalosporin impurity 1;7-Aminodeacetylcephalosporanic acid;7-Amino-3-(hydroxymethyl)-cephem-4-carboxylic acid;7-HACA;7-ADACA;SN-22995
CBNumber: CB5875043
Molecular Formula: C8H10N2O4S
Formula Weight: 230.24
MOL File: 15690-38-7.mol

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Hydroxymethyl-7-Aminocephalosporanic acid Property

Melting point:: 105-107°C
Boiling point:: 617.9±55.0 °C(Predicted)
Density: 1.74
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 2.68±0.50(Predicted)
form: Solid
color: White to Beige
InChI: InChI=1S/C8H10N2O4S/c9-4-6(12)10-5(8(13)14)3(1-11)2-15-7(4)10/h4,7,11H,1-2,9H2,(H,13,14)/t4-,7-/m1/s1
InChIKey: BQIMPGFMMOZASS-CLZZGJSISA-N
SMILES: N12[C@@]([H])([C@H](N)C1=O)SCC(CO)=C2C(O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2878
Product name: 7-Aminodeacetylcephalosporanic Acid
Packaging: 5G
Price: $70
Updated: 2025/07/31

TCI Chemical

Product number: A2878
Product name: 7-Aminodeacetylcephalosporanic Acid
Packaging: 25G
Price: $211
Updated: 2025/07/31

TRC

Product number: A603420
Product name: 7-Amino-deacetylcephalosporanicAcid
Packaging: 250mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: X5835
Product name: 7-Amino-deacetylcephalosporanicAcid
Packaging: 1g
Price: $37
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA36388
Product name: 7-Amino-3-(hydroxymethyl)-cephem-4-carboxylic acid
Packaging: 25mg
Price: $60
Updated: 2021/12/16

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Hydroxymethyl-7-Aminocephalosporanic acid Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

Intermediate in the semi-synthetic cephalosporins synthesis. Found in Acremonium chrysogenum.

Synthesis

957-68-6

15690-38-7

General procedure for the synthesis of (6R,7R)-7-amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid from 7-aminocephalosporanic acid (7-ACA): 27.2 g (0.1 mol) of 7-ACA were accurately weighed and placed in a reaction flask, to which 50 mL of methanol and 50 mL of water were added as solvents. 3.0 g of tetra-n-butyl ammonium chloride was added while stirring at a temperature of -5 to 5 °C. Subsequently, 2 mol/L sodium hydroxide solution was added slowly dropwise. After the dropwise addition was completed, the reaction temperature was maintained and stirring was continued for 0.5 to 1 hour. Upon completion of the reaction, the pH of the reaction solution was adjusted to neutral with 30% hydrochloric acid, at which point a solid precipitated. The solid product was collected by diafiltration and washed with anhydrous ethanol. Eventually, 20.7 g of dry white solid product was obtained. The product was analyzed by high performance liquid chromatography (HPLC) and the purity of the product was 97.35% (area normalization method) and the content of lactone impurities was 0.33%.

References

[1] Patent: CN105131017, 2017, B. Location in patent: Paragraph 0041-0042
[2] Synthetic Communications, 2003, vol. 33, # 14, p. 2475 - 2482
[3] Patent: CN106083894, 2016, A. Location in patent: Paragraph 0045; 0054; 0055; 0056; 0057
[4] Synthesis, 2012, vol. 2012, # 2, p. 207 - 214
[5] Farmaco, 2003, vol. 58, # 6, p. 409 - 418

Hydroxymethyl-7-Aminocephalosporanic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydroxymethyl-7-Aminocephalosporanic acid Suppliers

Canada 1 China 144 Germany 1 India 4 Spain 1 United Kingdom 1 United States 9 Global 161

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View Lastest Price from Hydroxymethyl-7-Aminocephalosporanic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Hydroxymethyl-7-Aminocephalosporanic acid 15690-38-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Hangzhou ICH Biofarm Co., Ltd

Product: Deacetyl-7-Aminocephalosporanic Acid 15690-38-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 20 tons
Release date: 2023-06-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7-Amino-deacetylcephalosporanic Acid 15690-38-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

15690-38-7, Hydroxymethyl-7-Aminocephalosporanic acidRelated Search:

7-Aminocephalosporanic acid Desacetyl-7-ACA Lactone Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate 3,5-DICHLORO-4-PYRIDINOL 3,5-DICHLORO-4-HYDROXYPYRIDINE SPECIALITY CHEMICALS Cefazedone Cephalothin sodium Cefotaxime Cephalothin cefaloglycin Cefuroxime Cefoxitin Cefdaloxime cefapirin Cefcapene Cefpodoxime cefaloram Cefoxitin sodium Cefoselis

7-ACA Impurity 1（Deacetyl 7-ACA）

7-HACA

Ceftriaxone Impurity 22

Cephalosporin impurity 1

7-ACA Impurity D

Cefazedone Impurity 11

(2S)-N-[(2S,4R)-4-acetamido-1-[[(2S)-2-[[(2R)-6-amino-2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)-1-oxopropyl]amino]-1-oxohexyl]amino]-4-methyl-1-oxopentyl]-[(2S)-2-[[(2R)-2-amino-1-oxo-3-(3-pyridiny

7-Amino-3-(hydroxymethyl)-cephem-4-carboxylic acid

Intermediate of cefoselis Sulfate (7-Amino-3-(hydroxymethyl)-3-cephem-4-carboxylic acid )

(6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-(Phenylacetylamino)deacetylcephalosporanic acid

7-ADACA

7-Aminodeacetylcephalosporanic acid

7β-Amino-3-(hydroxymethyl)cepham-3-ene-4-carboxylic acid

N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide

SN-22995

5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-amino-3-(hydroxymethyl)-8-oxo-, (6R-trans)-

Einecs 239-787-2

3-HydroxyMethyl-7-aMinoceph-3-eM-4-carboxylic Acid

6R,7R)-7-AMino-3-hydroxyMethylceph-3-eM-4-carboxylic Acid

7-AMino-3-(hydrox

Deacetyl-7-aMinocephalosporanic Acid

(6R-trans)-7-amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

DACA

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-aMino-3-(hydroxyMethyl)-8-oxo-, (6R,7R)-

HACA

2,6/2,7-ADA

Cephalosporin iMpurity (7-AMino-deacetylcephalosporanic Acid)

7-AMINO-3-(HYDROXYMETHYL)-3-CE

Cefazedone Related Impurity 11

D-7-ACA

Hydroxymethyl-7-ACA

Hydroxymethyl-7-Aminocephalosporanic acid

Deacetyl 7-ACA

7-ACA-D-7ACA

D-7-ACA 7-HACA

Cephalosporin Impurity A

Cefazedone Impurity 18

Cephalosporin impurity 1 (7-Amino-deacetylcephalosporanic Acid)

Ceftriaxone 7-ADCA Impurity

Hydroxymethyl-7-Aminocephalosporanic acid USP/EP/BP

D-7-ACA,Cefazedone Impurity 11

Desacetyl-7-amino cephalosporanic acid,

HACA/D-7-ACA

7-Amino-deacetylcephalosporanicAci

7-ACA Impurity 1(D-7-ACA)

15690-38-7

15690-35-7

Cefcapene

15690-38-7