Articaine hydrochloride

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Articaine hydrochloride

Product Name: Articaine hydrochloride
CAS No.: 23964-57-0
Chemical Name: Articaine hydrochloride
Synonyms: Ultracain;Ultracaine;Articaine HCI;IN STOCK ARTICAINE HYDROCHLORIDE CAS NO.23964-57-0;Hoe-045;CarticaineHCl;Articaine HCL powder;Articaine hydrochloride;Carticaine chlorhydrate;Artecaine hydrochloride
CBNumber: CB5875144
Molecular Formula: C13H20N2O3S.ClH
Formula Weight: 320.839
MOL File: 23964-57-0.mol

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Articaine hydrochloride Property

Melting point:: 177-178°
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: H2O: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Hygroscopic
InChI: InChI=1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H
InChIKey: GDWDBGSWGNEMGJ-UHFFFAOYSA-N
SMILES: C1(NC(=O)C(C)NCCC)C(C)=CSC=1C(=O)OC.Cl

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934990002
Toxicity: LD50 i.v. in mice: 37 mg/kg (Muschaweck, Rippel)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1093
Product name: Articaine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1881
Product name: Articaine Hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $250
Updated: 2024/03/01

Cayman Chemical

Product number: 17883
Product name: Articaine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 17883
Product name: Articaine (hydrochloride)
Purity: ≥98%
Packaging: 1g
Price: $917
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000079
Product name: Articaine hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000079
Price: $150
Updated: 2024/03/01

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Articaine hydrochloride Chemical Properties,Usage,Production

Description

Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to mepivacaine. Most local anesthetics act by abolishing voltage-gated sodium channel currents indiscriminately in all populations of neurons. Articaine is an amide local anesthetic most commonly used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine is reported to modify cardiac action potentials and ion currents only at concentrations higher than the therapeutic range needed to inhibit voltage-gated sodium channels.

Chemical Properties

White or almost white, crystalline powder.

Originator

Ultracain,Hoechst,W. Germany,1976

Uses

Articaine hydrochloride, belonging to the group of amide anesthetics, is a local anesthetic with a short duration of action. It is utilized for regional anesthesia in day-case surgeries such as arthroscopy, hand and foot surgery, and dentistry.

Manufacturing Process

3-α-Chloropropionylamino-2-carbomethoxy-4-methylthiophene (prepared from 3-amino-2-carbomethoxy-4-methylthiophene and chloropropionyl chloride) was dissolved in toluene and n-propylamine added. The whole mixture was heated to boiling for 6 to 7 hours. After cooling, the propylamine hydrochloride that had formed was removed by washing with water, The toluene phase was dried with sodium sulfate, and then the solvent and excess propylamine were removed by distillation. The oily residue was taken up in ether. The hydrochloride of 3-n-propylamino-α-propionylamino-2- carbomethoxy-4-methylthiophene was obtained by introducing hydrogen chloride gas or by means of methanolic hydrogen chloride. The base boils at 162°C to 167°C under 0.3 mm of mercury pressure and the hydrochloride melts at 177°C to 178°C.

brand name

Septanest (Cilag-Chemie, Switzerland); Septocaine (Cilag-Chemie, Switzerland); Ultracaine (Hoechst AG, Germany).

Therapeutic Function

Local anesthetic

Contact allergens

This local amide-type anesthetic is seldom reported as allergenic even in patients sensitized to other amidetype molecules like lidocaine, prilocaine, mepivacaine, or bupivacaine.

Biochem/physiol Actions

Articaine hydrochloride helps to alleviate pain and blocks transmission of the pain signal. Articaine is an amide local anesthetic widely used in dentistry. Articaine acts by inhibition of nerve impulse conduction by blockade of sodium channels.

Metabolism

Articaine is the only amide local anesthetic containing a thiophene aromatic ring rather than benzene. Because articaine hydrochloride is the only widely used amide local anesthetic that also contains an ester group, biotransformation of articaine hydrochloride occurs in both plasma (hydrolysis by plasma esterase—similarly to other ester local anesthetics) and liver (hepatic microsomal enzymes—similarly to other amide local anesthetics). The metabolism of articaine hydrochloride is initiated by hydrolysis of the carboxylic acid ester groups to obtain free carboxylic acid. Its primary metabolite, articainic acid, is pharmacologically inactive, undergoing additional biotransformation to form articainic acid glucuronide. Additional metabolites have been detected in animal studies. From this point, the reaction can follow several pathways: cleavage of carboxylic acid, formation of an acid amino group by internal cyclization, and oxidation.

Mode of action

Articaine Hydrochloride is the hydrochloride salt form of articaine, an amide-type local anesthetic. Its mechanism of action involves reversible blockage of nerve impulse conduction through binding to specific sodium ion channels on the membrane, thereby interfering with the electrical excitation in the nerve, slowing the propagation of the nerve impulse and reducing the rate of action potential rise. This results in a loss of sensation at the site of injection. Articaine hydrochloride is used for relief of pain in minor operations, usually in combination with the vasoconstrictor epinephrine.

Articaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Articaine hydrochloride Suppliers

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View Lastest Price from Articaine hydrochloride manufacturers

Nanjing Deda New Material Technology Ltd.

Product: Articaine hydrochloride 23964-57-0
Price: US $10.00-30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100ton/ month
Release date: 2024-04-01

Wuhan Haorong Biotechnology Co.,Ltd

Product: Articaine hydrochloride 23964-57-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500
Release date: 2023-07-14

ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD

Product: Articaine hydrochloride 23964-57-0
Price: US $1.00/mg
Min. Order: 1000mg
Purity: 99
Supply Ability: 5ton/month
Release date: 2022-05-30

23964-57-0, Articaine hydrochlorideRelated Search:

RESMETHRIN Kresoxim-methyl Cephalothin sodium Topotecan hydrochloride Thifensulfuron methyl Thiophene Mepivacaine Methyl acrylate D-Glucosamine hydrochloride Mepivacaine hydrochloride Etidocaine Tetrahydrothiophene Thiophanate-methyl Methylparaben Bensulfuron methyl Articaine Methyl Parathion-methyl

methyl 4-methyl-3-[[(1-oxo-2-(propylamino)propyl]amino]-2-thenoate monohydrochloride

CarticaineHCl

Ultracaine

CARTICAINE HYDROCHLORIDE

Ultracain

Articaine hydrochloride

Methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate hydrochloride

Articaine Hydrochloride (125 mg)

4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylic acid methyl ester hydrochloride

Methyl 4-methyl-3-[(N-propylalanyl)amino]-2-thiophenecarboxylate hydrochloride

Articaine HCI

4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride

Carticaine chlorhydrate

Articaine Hydrochloride Impurity

methyl 4-methyl-3-(2-(propylamino)propanamido)thiophene-2-carboxylate hydrochloride

methyl 4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylate hydrochloride

IN STOCK ARTICAINE HYDROCHLORIDE CAS NO.23964-57-0

ARTICAINE HYDROCHLORIDE CAS NO.23964-57-0

ARTICAINE HYDROCHLORIDE 99%

Articaine hydrochloride 23964-57-0

Hoe-045

Methyl 4-methyl-3-[[(2RS)-2-(propylamino)propanoyl]-amino]thiophene-2-carboxylate hydrochloride

Articaine Impurities1812

Articaine HCL powder

Articaine Hydrochloride (1042918)

6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride

Articaine hydrochloride/Articaine hcl

Articaine hydrochloride hcl

Artecaine hydrochloride

23964-57-0

C13H20N2O3SHCl

C13H20N2O3SClH

API

research chemical

Pharmaceutical intermediate

local anesthetic

BDO