4,4'-propylenebis(piperazine-2,6-dione)

Product Name: 4,4'-propylenebis(piperazine-2,6-dione)
CAS No.: 21416-67-1
Chemical Name: 4,4'-propylenebis(piperazine-2,6-dione)
Synonyms: Troxozone;RAZOXANUM;Propyliminum;rac-Dexrazoxane;4,4'-(Propane-1,2-diyl);Razoxane, 10 mM in DMSO;bis(piperazine-2,6-dione);-propylenebis(piperazine-2,6-dione);4,4'-propylenebis(piperazine-2,6-dione);4,4'-Propane-1,2-diyldipiperazine-2,6-dione
CBNumber: CB5918838
Molecular Formula: C11H16N4O4
Formula Weight: 268.27
MOL File: 21416-67-1.mol

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4,4'-propylenebis(piperazine-2,6-dione) Property

Melting point:: 237-239°
Boiling point:: 411.43°C (rough estimate)
Density: 1.2576 (rough estimate)
refractive index: 1.6081 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: soluble40mg/mL
form: solid
pka: 11.00±0.20(Predicted)
color: White to off-white
Water Solubility: 3g/L(25 ºC)

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Safety

WGK Germany: 3
RTECS: TL6389900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R8657
Product name: Razoxane
Purity: >98% (HPLC)
Packaging: 5mg
Price: $115
Updated: 2025/07/31

TRC

Product number: R128060
Product name: Razoxane
Packaging: 1g
Price: $715
Updated: 2021/12/16

Matrix Scientific

Product number: 076182
Product name: 4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
Purity: 95+%
Packaging: 250mg
Price: $907
Updated: 2021/12/16

AK Scientific

Product number: E393
Product name: Razoxane
Packaging: 1g
Price: $1063
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008266
Product name: RAZOXANE
Purity: 95.00%
Packaging: 1G
Price: $1575
Updated: 2021/12/16

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4,4'-propylenebis(piperazine-2,6-dione) Chemical Properties,Usage,Production

Uses

Razoxane is an inhibitor of Topo II.

Definition

ChEBI: Razoxane is a N-alkylpiperazine.

Biological Activity

Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown th at razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Safety Profile

Suspected human carcinogen producing leukemia and skin tumors. Moderately toxic by intraperitoneal route. Human effects: normocytic anemia and thrombocytopenia. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

in vivo

Early treatment with Razoxane (30 mg/kg i.p. from day -2 to +14) shows a greater inhibition of pulmonary metastases than later treatment (30 mg/kg i.p. from day +14 to +28 after transplantation)^[2].

Animal Model:	Sprague-Dawley rats^[2]
Dosage:	30 mg/kg or 10 mg/kg per day
Administration:	Intraperitoneally (i.p.) from 2 days before to 14 days after tumor transplantation
Result:	Resulted in a dose-dependent prolongation of median survival time (83 or 48 days respectively, versus 38 days for the control group), but showed no influence on the growth of the primary tumor.

IC 50

Topoisomerase II

4,4'-propylenebis(piperazine-2,6-dione) Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-propylenebis(piperazine-2,6-dione) Suppliers

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21416-67-1, 4,4'-propylenebis(piperazine-2,6-dione) Related Search:

polyethyleneimine Dexrazoxane Ethyl dimorpholine

4,4'-propylenebis(piperazine-2,6-dione)

4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)

RAZOXANUM

4,4'-(1-Methylethylene)bis(2,6-piperazinedione)

4,4'-Propane-1,2-diyldipiperazine-2,6-dione

Propyliminum

4-[3-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione

4,4'-(Propane-1,2-diyl)

bis(piperazine-2,6-dione)

Troxozone

-propylenebis(piperazine-2,6-dione)

4,4'-propylenebis(piperazine-2,6-dione) USP/EP/BP

4,5,9,10-Pyrenetetrone,2,7-bis(1,6-dimethylethyl)-

rac-Dexrazoxane

ICRF 159,ICRF159,ICRF-159,Topoisomerase II Inhibitor,Razoxane,RCC,Inhibitor,Topoisomerase,renal cell carcinoma,inhibit

Razoxane (ICRF-159), PDGF beta-receptor inhibitor

Razoxane, 10 mM in DMSO

21416-67-1

Angiogenesis and metastasis.