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Bunitrolol

Product Name
Bunitrolol
CAS No.
34915-68-9
Chemical Name
Bunitrolol
Synonyms
Bunitrolol;dl-Bunitolol;2-nitrilo-n-tert-butylphenoxypropanolamine;1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol;3-(tert-butylamino)-1-(m-cyanophenoxy)-2-propano;1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol;o-(3-(tert-butylamino)-2-hydroxypropoxy)-benzonitril;o-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile;2-(3-(tert-ButylaMino)-2-hydroxypropoxy)benzonitrile;1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane
CBNumber
CB5947087
Molecular Formula
C14H20N2O2
Formula Weight
248.32
MOL File
34915-68-9.mol
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Bunitrolol Property

Melting point:
163-165 °C
Boiling point:
414.2±35.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly, Sonicated)
form 
Solid
pka
13.76±0.20(Predicted)
color 
Colourless to Pale Yellow Sticky Oil
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B689440
Product name
Bunitrolol
Packaging
100mg
Price
$1390
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB168201
Product name
Bunitrolol
Packaging
2mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB168201
Product name
Bunitrolol
Packaging
5mg
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB168201
Product name
Bunitrolol
Packaging
10mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008656
Product name
BUNITROLOL
Purity
95.00%
Packaging
10MG
Price
$697.34
Updated
2021/12/16
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Bunitrolol Chemical Properties,Usage,Production

Originator

St resson,Boehringer Ingelheim,Boehringer Ingelheim,1976

Uses

Bunitrolol is a beta adrenoceptor antagonist that is used as an antihypertensive and antianginal agent.

Definition

ChEBI: Bunitrolol is an aromatic ether.

Manufacturing Process

Epichlorohydrin and 2-cyanophenol are first reacted to give 1-(2- cyanophenoxy)-2,3-epoxypropane.
15 g (0.085 mol) of 1-(2-cyanophenoxy)-2,3-epoxy propane were dissolved in 100 ml of ethanol and 18.6 g (0.255 mol) of t-butylamine were added thereto. After standing for 1 hour at room temperature, the solution was heated at 60°-70°C for 2 hours after which the volatile constituents were distilled off in vacuo. The residue was digested with dilute HCl, and the insoluble constituents were vacuum filtered off. Then the filtrate was made alkaline with NaOH and the precipitating base was taken up in ether. After the ether solution had been dried over MgSO4, the ether was distilled off and the residue was dissolved in ethanol and by addition of ethereal HCl, the hydrochloride was precipitated there from in crystalline form which after recrystallization from ethanol with an addition of ether gave9.8 g of 1-(2- cyanophenoxy)-2-hydroxy-3-t-butylamino propane hydrochloride having a melting point of 163°-165°C.

Therapeutic Function

Antianginal

Bunitrolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Bunitrolol Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65

34915-68-9, Bunitrolol Related Search:


  • Bunitrolol
  • 1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane
  • 1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol
  • 1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol
  • Benzonitrile, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-
  • dl-Bunitolol
  • 2-nitrilo-n-tert-butylphenoxypropanolamine
  • 3-(tert-butylamino)-1-(m-cyanophenoxy)-2-propano
  • o-(3-(tert-butylamino)-2-hydroxypropoxy)-benzonitril
  • 2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyloxy]benzonitrile
  • o-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile
  • 2-(3-(tert-ButylaMino)-2-hydroxypropoxy)benzonitrile
  • 2-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-benzonitril
  • 34915-68-9