ChemicalBook > CAS DataBase List > 3,5-Dimethoxypyridine

3,5-Dimethoxypyridine

Product Name
3,5-Dimethoxypyridine
CAS No.
18677-48-0
Chemical Name
3,5-Dimethoxypyridine
Synonyms
Impurity SMA-6;3,5-Dimethoxypyridine;Perampanel Impurity 13;Pyronoprene Impurity 16;Pyridine, 3,5-diMethoxy-;3,5-Dimethoxypyridine ISO 9001：2015 REACH
CBNumber
CB5967391
Molecular Formula
C7H9NO2
Formula Weight
139.15
MOL File
18677-48-0.mol
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3,5-Dimethoxypyridine Property

Boiling point:
225.6±20.0 °C(Predicted)
Density 
1.064±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Dichloromethane, Ethyl Acetate, Methanol
form 
Oil
pka
4.00±0.10(Predicted)
color 
Colorless to Pale Yellow
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D460743
Product name
3,5-Dimethoxypyridine
Packaging
500mg
Price
$110
Updated
2021/12/16
Usbiological
Product number
D3691-75A
Product name
3,5-Dimethoxypyridine
Packaging
1g
Price
$460
Updated
2021/12/16
Apolloscientific
Product number
OR932195
Product name
3,5-Dimethoxypyridine
Purity
98%
Packaging
5g
Price
$551
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD22228
Product name
3,5-Dimethoxypyridine
Packaging
5G
Price
$555
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078038
Product name
3,5-DIMETHOXYPYRIDINE
Purity
95.00%
Packaging
1G
Price
$721.88
Updated
2021/12/16
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3,5-Dimethoxypyridine Chemical Properties,Usage,Production

Chemical Properties

Colorless to Pale Yellow Oil

Uses

3,5-Dimethoxypyridine (cas# 18677-48-0) is a compound useful in organic synthesis.

Synthesis

124-41-4

71902-33-5

18677-48-0

1. 3,5-difluoropyridine (5.4 g, 46.8 mmol, 1 eq.) was dissolved in methanol (45 mL). 2. Sodium methanolate (7.5 g, 140.4 mmol) was added to the above solution. 3. The reaction mixture was divided equally into three microwave reactor tubes. 4. Heat each tube separately in the microwave reactor at 135 °C for 1 hour. 5. 5. Upon completion of the reaction, the contents of the three reaction tubes were combined and concentrated. 6. The concentrate was diluted with a mixture of ethyl acetate (100 mL) and brine (30 mL). 7. The organic layer was separated, dried over anhydrous sodium sulfate, and concentrated. 8. Redissolve the crude product in methanol (45 mL) and add sodium methanolate (7.5 g, 140.4 mmol). 9. Steps 3 through 7 were repeated. 10. Dissolve the final crude product in a mixture of ethyl acetate (200 mL) and brine (30 mL). 11. Separate the organic layer, dry with anhydrous sodium sulfate, and concentrate. 12. The product was purified by silica gel column chromatography using a mixture of ethyl acetate and hexane as eluent to afford 3,5-dimethoxypyridine (3.73 g, 57% yield) as an off-white solid. 13. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.98 (d, J=2.4 Hz, 2H), 6.76 (t, J=2.4 Hz, 1H), 3.88 (s, 6H). 14. lRMS (M+H+) m/z 140.1.

References

[1] Patent: WO2013/102145, 2013, A1. Location in patent: Paragraph 0315
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 321 - 326

3,5-Dimethoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Dimethoxypyridine manufacturers

Dideu Industries Group Limited
Product
3,5-Dimethoxypyridine 18677-48-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
3,5-DiMethoxypyridine 18677-48-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
3,5-Dimethoxypyridine 18677-48-0
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

18677-48-0, 3,5-DimethoxypyridineRelated Search:

Sodium erythorbate 2-PHENYL-1,3,2-DIOXABORINANE PeraMpanel 6'-Methoxy-2,3'-bipyridine 3,5-Dibromopyridine PeraMpanel 2-Cyanophenylboronic acid Phenylboronic acid 1-Phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one 2-Bromobenzonitrile 2-(2-cyanophenyl)benzonitrile 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 2,5-Dibromopyridine 5-Bromo-2-methoxypyridine PRMWGUBFXWROHD-MYWHSQMISA-N 5'-(2-cyanophenyl)-6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine] 1-oxide 2-bromo-3-(1,3,2-dioxaborinan-2-yl)benzonitrile 4-(6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile

  • 3,5-Dimethoxypyridine
  • Pyridine, 3,5-diMethoxy-
  • Perampanel Impurity 13
  • 3,5-Dimethoxypyridine ISO 9001：2015 REACH
  • Pyronoprene Impurity 16
  • Impurity SMA-6
  • 18677-48-0
  • API intermediates
  • Pyridines
  • Aromatics
  • Bases & Related Reagents
  • Nucleotides