3,5-Dimethoxypyridine
- Product Name
- 3,5-Dimethoxypyridine
- CAS No.
- 18677-48-0
- Chemical Name
- 3,5-Dimethoxypyridine
- Synonyms
- Impurity SMA-6;3,5-Dimethoxypyridine;Perampanel Impurity 13;Pyronoprene Impurity 16;Pyridine, 3,5-diMethoxy-;3,5-Dimethoxypyridine ISO 9001：2015 REACH
- CBNumber
- CB5967391
- Molecular Formula
- C7H9NO2
- Formula Weight
- 139.15
- MOL File
- 18677-48-0.mol
3,5-Dimethoxypyridine Property
- Boiling point:
- 225.6±20.0 °C(Predicted)
- Density
- 1.064±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Dichloromethane, Ethyl Acetate, Methanol
- form
- Oil
- pka
- 4.00±0.10(Predicted)
- color
- Colorless to Pale Yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D460743
- Product name
- 3,5-Dimethoxypyridine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- D3691-75A
- Product name
- 3,5-Dimethoxypyridine
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- FD22228
- Product name
- 3,5-Dimethoxypyridine
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- D34092
- Product name
- 3,5-Dimethoxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- W4037
- Product name
- 3,5-Dimethoxypyridine
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
3,5-Dimethoxypyridine Chemical Properties,Usage,Production
Chemical Properties
Colorless to Pale Yellow Oil
Uses
3,5-Dimethoxypyridine (cas# 18677-48-0) is a compound useful in organic synthesis.
Synthesis
124-41-4
71902-33-5
18677-48-0
1. 3,5-difluoropyridine (5.4 g, 46.8 mmol, 1 eq.) was dissolved in methanol (45 mL). 2. Sodium methanolate (7.5 g, 140.4 mmol) was added to the above solution. 3. The reaction mixture was divided equally into three microwave reactor tubes. 4. Heat each tube separately in the microwave reactor at 135 °C for 1 hour. 5. 5. Upon completion of the reaction, the contents of the three reaction tubes were combined and concentrated. 6. The concentrate was diluted with a mixture of ethyl acetate (100 mL) and brine (30 mL). 7. The organic layer was separated, dried over anhydrous sodium sulfate, and concentrated. 8. Redissolve the crude product in methanol (45 mL) and add sodium methanolate (7.5 g, 140.4 mmol). 9. Steps 3 through 7 were repeated. 10. Dissolve the final crude product in a mixture of ethyl acetate (200 mL) and brine (30 mL). 11. Separate the organic layer, dry with anhydrous sodium sulfate, and concentrate. 12. The product was purified by silica gel column chromatography using a mixture of ethyl acetate and hexane as eluent to afford 3,5-dimethoxypyridine (3.73 g, 57% yield) as an off-white solid. 13. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.98 (d, J=2.4 Hz, 2H), 6.76 (t, J=2.4 Hz, 1H), 3.88 (s, 6H). 14. lRMS (M+H+) m/z 140.1.
References
[1] Patent: WO2013/102145, 2013, A1. Location in patent: Paragraph 0315
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 321 - 326
3,5-Dimethoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dimethoxypyridine manufacturers
- Product
- 3,5-Dimethoxypyridine 18677-48-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-28
- Product
- 3,5-DiMethoxypyridine 18677-48-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 3,5-Dimethoxypyridine 18677-48-0
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04