3-Bromo-5-ethoxypyridine
- Product Name
- 3-Bromo-5-ethoxypyridine
- CAS No.
- 17117-17-8
- Chemical Name
- 3-Bromo-5-ethoxypyridine
- Synonyms
- 5-bromo-3-ethoxypyridine;Pyridine, 3-broMo-5-ethoxy-
- CBNumber
- CB5967407
- Molecular Formula
- C7H8BrNO
- Formula Weight
- 202.05
- MOL File
- 17117-17-8.mol
3-Bromo-5-ethoxypyridine Property
- Melting point:
- 9°C(lit.)
- Boiling point:
- 240°C(lit.)
- refractive index
- 1.5540 to 1.5580
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- B5000
- Product name
- 3-Bromo-5-ethoxypyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- B5000
- Product name
- 3-Bromo-5-ethoxypyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $322
- Updated
- 2025/07/31
- Product number
- B696073
- Product name
- 3-Bromo-5-ethoxypyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB153707
- Product name
- 3-Bromo-5-ethoxypyridine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB153707
- Product name
- 3-Bromo-5-ethoxypyridine
- Packaging
- 2g
- Price
- $150
- Updated
- 2021/12/16
3-Bromo-5-ethoxypyridine Chemical Properties,Usage,Production
Synthesis
625-92-3
64-17-5
17117-17-8
Sodium metal (4.60 g, 200 mmol) was added in batches to anhydrous ethanol (100 mL) under nitrogen protection, keeping the reaction temperature at 0-5 °C. The mixture was stirred to slowly warm up to room temperature over 18 hours. Subsequently, 3,5-dibromopyridine (31.5 g, 133 mmol) and N,N-dimethylformamide (DMF, 100 mL) were added to the reaction system. The reaction mixture was heated to 70 °C with continuous stirring for 48 hours. After completion of the reaction, the brown mixture was cooled to room temperature, slowly poured into water (600 mL) and extracted with ether (3 x 500 mL). The ether extracts were combined, dried with anhydrous sodium sulfate, filtered and concentrated by rotary evaporator. The final product was purified by vacuum distillation to give 22.85 g (85.0% yield) of 5-bromo-3-ethoxypyridine as an oil with a boiling point of 89-90 °C (2.8 mmHg). A boiling point of 111 °C (5 mmHg) has been reported in the literature (see K. Clarke et al., J. Chem. Soc. 1885 (1960)).
References
[1] Patent: WO2006/23630, 2006, A2. Location in patent: Page/Page column 60
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4126 - 4141
[3] Patent: WO2010/96389, 2010, A1. Location in patent: Page/Page column 37; 39
[4] Patent: WO2010/135014, 2010, A1. Location in patent: Page/Page column 45-47
[5] Patent: WO2011/87776, 2011, A1. Location in patent: Page/Page column 48; 51
3-Bromo-5-ethoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-5-ethoxypyridine Suppliers
- Tel
- --
- Fax
- --
- Country
- France
- ProdList
- 303
- Advantage
- 58
- Tel
- --
- Fax
- --
- him@interchim.com
- Country
- France
- ProdList
- 2725
- Advantage
- 58