2-Amino-5-bromo-3-benzloxypyridine

Product Name: 2-Amino-5-bromo-3-benzloxypyridine
CAS No.: 754230-78-9
Chemical Name: 2-Amino-5-bromo-3-benzloxypyridine
Synonyms: EOS-60758;2-Amino-5-bromo-3-benzloxypyridine;3-Benzyloxy-5-bromo-2-pyridinamine;2-Amino-5-bromo-3-benzyloxypyridine;3-(benzyloxy)-5-bromopyridin-2-amine;3-(benzyloxy)-5-bromopyridine-2-amine;5-bromo-3-phenylmethoxypyridin-2-amine;2-Amino-3-benzyloxy-5-bromopyridine,96%;2-AMino-3-benzyloxy-5-broMopyridine, 96%;5-bromo-3-(phenylmethoxy)- 2-Pyridinamine
CBNumber: CB21481844
Molecular Formula: C12H11BrN2O
Formula Weight: 279.13
MOL File: 754230-78-9.mol

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2-Amino-5-bromo-3-benzloxypyridine Property

Melting point:: 99 ºC
Density: 1.502
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B130158
Product name: 3-(Benzyloxy)-5-bromopyridin-2-amine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W004158
Product name: 3-(Benzyloxy)-5-bromopyridin-2-amine
Purity: 99.97%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA152972
Product name: 2-Amino-5-bromo-3-benzyloxypyridine
Packaging: 2mg
Price: $59
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA152972
Product name: 2-Amino-5-bromo-3-benzyloxypyridine
Packaging: 5mg
Price: $117
Updated: 2021/12/16

ChemScene

Product number: CS-W004158
Product name: 3-(Benzyloxy)-5-bromopyridin-2-amine
Purity: 99.97%
Packaging: 5g
Price: $153
Updated: 2021/12/16

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2-Amino-5-bromo-3-benzloxypyridine Chemical Properties,Usage,Production

Synthesis

24016-03-3

754230-78-9

The general procedure for the synthesis of 2-amino-5-bromo-3-benzyloxypyridine from 2-amino-3-benzyloxypyridine was as follows: 2-amino-3-benzyloxypyridine (85.0 g, 0.42 mol) was dissolved in 10% aqueous sulfuric acid solution (1000 mL). The resulting yellow solution was cooled to 0 to 4°C, followed by slow dropwise addition of a solution of bromine (80.5 g, 0.50 mol) in acetic acid (276 g, 4.6 mol) over a period of 2 hours. The reaction mixture was transformed into a red suspension and stirring was continued at 0°C for 2.5 hours. The reaction mixture was poured into a mixture of ice water (500 mL) and dichloromethane (1000 mL), and the pH was adjusted to 8 by adding a 25% ammonia solution (~600 mL) while stirring the two-phase mixture thoroughly. The organic and aqueous phases were separated and the aqueous phase was further extracted with dichloromethane (3 x 500 mL). All organic phases were combined, washed with water (400 mL) and dried with sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by fast column chromatography [silica gel 1 kg, eluent: petroleum ether/ethyl acetate = 7:3 (v/v)]. The final product was 96.0 g of 2-amino-5-bromo-3-benzyloxypyridine as a brown solid in 81% yield. The melting point of the product was 109-110°C. 1H-NMR (CDCl3, 200 MHz) data were as follows: δ = 4.73 (broad single peak, 2H), 5.04 (single peak, 2H), 7.08 (double peak, 1H), 7.40 (multiple peaks, 5H), 7.73 (double peaks, 1H).

References

[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 19, p. 7669 - 7678
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 24, p. 6240 - 6264
[3] Patent: WO2005/58325, 2005, A1. Location in patent: Page/Page column 39
[4] Patent: WO2005/90358, 2005, A2. Location in patent: Page/Page column 74
[5] Journal of the American Chemical Society, 2015, vol. 137, # 27, p. 8851 - 8857

2-Amino-5-bromo-3-benzloxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-bromo-3-benzloxypyridine Suppliers

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