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Panobinostat

Product Name
Panobinostat
CAS No.
404950-80-7
Chemical Name
Panobinostat
Synonyms
CS-422;LBH-589;NVP-LBH589;Palcociclib;panobinosta;PANOBINOSTAT;2-Acrylamide;Palmer than he;Panobinostat D7;Panobinostat, >=98%
CBNumber
CB61009161
Molecular Formula
C21H23N3O2
Formula Weight
349.43
MOL File
404950-80-7.mol
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Panobinostat Property

Melting point:
114-117?C
Density 
1.241±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
form 
solid
pka
8.71±0.23(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Safety

Risk Statements 
22-36/37/38-20
Safety Statements 
24/25
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13280
Product name
Panobinostat
Purity
≥98%
Packaging
5mg
Price
$29
Updated
2024/03/01
Cayman Chemical
Product number
13280
Product name
Panobinostat
Purity
≥98%
Packaging
10mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
13280
Product name
Panobinostat
Purity
≥98%
Packaging
50mg
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
13280
Product name
Panobinostat
Purity
≥98%
Packaging
25mg
Price
$147
Updated
2021/12/16
Usbiological
Product number
170036
Product name
Panobinostat
Packaging
1mg
Price
$293
Updated
2021/12/16
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Panobinostat Chemical Properties,Usage,Production

Description

Panobinostat is a potent inhibitor of all histone deacetylases (HDACs), with Ki values ranging from 0.6 to 31 nM for HDAC1-11. Through this action, it leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells. It has potential applications in several different forms of cancer as well as in spinal muscular atrophy and HIV therapy.

Chemical Properties

Yellow Solid

Uses

The novel labelled histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.

Uses

The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.

Definition

ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its la tate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.

Clinical Use

Histone deacetylase (HDAC) inhibitor:
Treatment of relapsed and/or refractory multiple myeloma

target

HDAC (MOLT-4 cells)

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: avoid with dextromethorphan possibly increased risk of ventricular arrhythmias with methadone - avoid.
Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone and possibly disopyramide - avoid.
Antibacterials: increased risk of ventricular arrhythmias with clarithromycin and moxifloxacin - avoid; avoid with rifampicin.
Antidepressants: avoid with St John’s wort.
Antiepileptics: avoid with carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone.
Antifungals: concentration increased by ketoconazole and possibly posaconazole and voriconazole - reduce panobinostat dose; concentration possibly increased by itraconazole - avoid.
Antimalarials: possibly increased risk of ventricular arrhythmias with chloroquine - avoid.
Antipsychotics: avoid with pimozide.
Antivirals: concentration possibly increased by ritonavir and saquinavir - reduce dose of panobinostat.
Beta-blockers: possibly increased risk of ventricular arrhythmias with sotalol - avoid.
Grapefruit juice: avoid concomitant use.
5HT3 antagonists: possibly increased risk of ventricular arrhythmias with granisetron and ondansetron - avoid with granisetron.

Metabolism

Panobinostat is extensively metabolised, and a large fraction of the dose is metabolised before reaching the systemic circulation by reduction, hydrolysis, oxidation and glucuronidation. Oxidative metabolism of panobinostat played a less prominent role, with approximately 40% of the dose eliminated by this pathway. Cytochrome P450 3A4 (CYP3A4) is the main oxidation enzyme, with potential minor involvement of CYP2D6 and 2C19.
Panobinostat represented 6-9% of the drug-related exposure in plasma. The parent substance is deemed to be responsible for the overall pharmacological activity of panobinostat.
After a single oral dose of [14C]-panobinostat in patients, 29-51% of administered radioactivity is excreted in the urine and 44-77% in the faeces. Unchanged panobinostat accounted for <2.5% of the dose in urine and <3.5% of the dose in faeces.

storage

Store at -20°C

References

1) Geng et al. (2006), Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer; Cancer Res., 66 11298 2) George et al. (2005), Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3; Blood, 105 1768 3) Maiso et al. (2006), The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance; Cancer Res., 66 5781

Panobinostat Preparation Products And Raw materials

Raw materials

Preparation Products

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Panobinostat Suppliers

Canada 1 China 209 China Hong Kong 1 India 3 United Kingdom 3 United States 28 Global 245
VDM Biochemicals
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marketing@targetmol.com
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View Lastest Price from Panobinostat manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Panobinostat 404950-80-7
Price
US $35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-29
Hebei Yanxi Chemical Co., Ltd.
Product
Panobinostat 404950-80-7
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-15
Shaanxi Haibo Biotechnology Co., Ltd
Product
Panobinostat 404950-80-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29

404950-80-7, PanobinostatRelated Search:

Zafirlukast Sivelestat sodium Mupirocin Tacrolimus Pemigatinib Chidamide Bendamustine Panitumumab Itraconazole Bortezomib Vorinostat Belinostat (PXD101) (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone Entinostat Ibrutinib Panobinostat cinnamoylhydroxamic acid

  • (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE
  • N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide
  • LBH-589/Panobinostat
  • LBH-589
  • PANOBINOSTAT
  • 2-Propenamide, N-hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)-, (2E)-
  • NVP-LBH589
  • Panobinostat (LBH589)
  • (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
  • N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide Panobinostat (LBH589)
  • Panobinostat N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide
  • panobinostat (HDAC inhibitor)
  • Panobinostat (LBH589, NVP-LBH589)
  • Palcociclib
  • Panobinostat, >=98%
  • LBH-589; LBH589; NVP-LBH589
  • CS-422
  • LBH 589 - NVP-LBH 589 | Panobinostat
  • 3-[4-[2-(2-Methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenohydroxamic acid
  • (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
  • Panobinostat USP/EP/BP
  • 3-[4-[2-(2-Methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E...
  • Panobinostat D7
  • 3-[4-[2-(2-Methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenohydroxamic acid　　　　　　N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide
  • Palmer than he
  • LBH 589,Human immunodeficiency virus,Histone deacetylases,HIV,HDAC,LBH-589,Autophagy,inhibit,Panobinostat,Inhibitor,Apoptosis
  • panobinosta
  • 2-Acrylamide
  • Papistatin impurity
  • Panobinostat, 10 mM in DMSO
  • 404950-80-7
  • C21H19D4N3O2
  • API
  • Inhibitor
  • Intracellular Signaling
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Isotope Labelled Compounds