ChemicalBook > CAS DataBase List > Penpulimab
Penpulimab
- Product Name
- Penpulimab
- CAS No.
- 2350298-92-7
- Chemical Name
- Penpulimab
- Synonyms
- Penpulimab;Penpulimab (anti-PDCD1);Research Grade Penpulimab;Research Grade Penpulimab(DHH02225)
- CBNumber
- CB610617014
- Formula Weight
- 0
- MOL File
- Mol file
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Penpulimab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
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Penpulimab Chemical Properties,Usage,Production
Uses
Penpulimab is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities[1].
in vivo
Penpulimab (5 mg/kg; i.p.; twice a week, 3weeks) inhibits tumor growth in mice[2].
| Animal Model: | MC38-hPD-L1 tumor-bearing B-hPD-1 humanized mouse model[2] |
| Dosage: | 5 mg/kg |
| Administration: | IP, twice a week, 3weeks |
| Result: | Showed moderate inhibition of tumor growth (tumor volume: 58.4% of control group). Treatment combined with anlotinib (1 mg/kg, every day, p.o) significantly decreased tumor volume to 36.5% of control group. |
References
[1] Huang Z, et al. Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events. Front Immunol. 2022 Jun 27;13:924542. DOI:10.3389/fimmu.2022.924542
[2] Yunlong Shan, et al. Anlotinib enhanced penpulimab efficacy through remodeling of tumor vascular architecture and immune microenvironment in hPD-L1/hPD-1 humanized mouse model. Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021) 2581-2581.
Penpulimab Preparation Products And Raw materials
Raw materials
Preparation Products
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