2-(Trifluoromethyl)pyrimidine-5-carboxylic acid

Product Name: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
CAS No.: 306960-77-0
Chemical Name: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
Synonyms: EOS-61863;2-(Trifluoromethyl)pyrimidine-5-carboxylicaci;2-(Trifluoromethyl)-5-pyrimidinecarboxylic Acid;2-(Trifluoromethyl)pyrimidine-5-carboxylic acid;5-PyriMidinecarboxylic acid, 2-(trifluoroMethyl)-;2-(Trifluoromethyl)pyrimidine-5-carboxylicacid,97%;5-Pyrimidinecarboxylic acid, 2-(trifluoromethyl)- (9CI);2-(Trifluoromethyl)pyrimidine-5-carboxylic acid ISO 9001：2015 REACH
CBNumber: CB61082227
Molecular Formula: C6H3F3N2O2
Formula Weight: 192.1
MOL File: 306960-77-0.mol

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2-(Trifluoromethyl)pyrimidine-5-carboxylic acid Property

Melting point:: 170-175℃
Boiling point:: 220.7±40.0 °C(Predicted)
Density: 1.575±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder
pka: 2.23±0.10(Predicted)
color: Pale yellow
Water Solubility: Slightly soluble in water.

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-60-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 740446
Product name: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
Purity: 97%
Packaging: 500mg
Price: $140
Updated: 2023/06/20

TRC

Product number: T895700
Product name: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC50209
Product name: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $68
Updated: 2021/12/16

Matrix Scientific

Product number: 041240
Product name: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $152
Updated: 2021/12/16

AK Scientific

Product number: X5569
Product name: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
Packaging: 500mg
Price: $164
Updated: 2021/12/16

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2-(Trifluoromethyl)pyrimidine-5-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow solid

Uses

2-(Trifluoromethyl)pyrimidine-5-carboxylic acid is used as pharmaceutical intermediate.

Synthesis

304693-64-9

306960-77-0

General procedure for the synthesis of 2-(trifluoromethyl)pyrimidine-5-carboxylic acid from ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate: To a 1 M aqueous lithium hydroxide solution (380 mL, 379.3 mmol) was added a solution of ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate (56.8 g, 252.8 mmol) dissolved in tetrahydrofuran (THF, 500 mL). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, it was concentrated under vacuum to remove the organic solvent. The remaining aqueous solution was acidified with concentrated hydrochloric acid to pH 1. The resulting precipitate was collected by vacuum filtration to afford 44.4 g (91% yield) of 2-trifluoromethylpyrimidine-5-carboxylic acid as an off-white powder. The product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 9.44 (s, 2H). retention time (Rt) = 0.81 min by LCMS (Analytical Method A), and mass spectra (ESI negative ion mode): m/z = 190.9 ([M-H]-).

References

[1] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 362; 363
[2] Journal of medicinal chemistry, 2000, vol. 43, # 21, p. 3995 - 4004
[3] Patent: US2009/131431, 2009, A1. Location in patent: Page/Page column 148
[4] Patent: WO2007/36733, 2007, A1. Location in patent: Page/Page column 223

2-(Trifluoromethyl)pyrimidine-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Trifluoromethyl)pyrimidine-5-carboxylic acid Suppliers

Austria 1 Canada 1 China 127 Europe 1 Germany 1 India 3 Ukraine 1 United Kingdom 1 United States 13 Global 149

Pure Chemistry Scientific Inc.

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View Lastest Price from 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid 306960-77-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid 306960-77-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-02

306960-77-0, 2-(Trifluoromethyl)pyrimidine-5-carboxylic acidRelated Search:

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5-Pyrimidinecarboxylic acid, 2-(trifluoromethyl)- (9CI)

2-(Trifluoromethyl)pyrimidine-5-carboxylic acid

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EOS-61863

2-(Trifluoromethyl)pyrimidine-5-carboxylicacid,97%

2-(Trifluoromethyl)pyrimidine-5-carboxylicaci

2-(Trifluoromethyl)pyrimidine-5-carboxylic acid ISO 9001：2015 REACH

2-(Trifluoromethyl)-5-pyrimidinecarboxylic Acid

306960-77-0

PYRIMIDINE

Pyrimidine series