4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde

Product Name: 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde
CAS No.: 770-31-0
Chemical Name: 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde
Synonyms: Benzene,1-ethenyl-8-nitro-;2-METHYLTHIO 4-AMINO 5-FORMYL PYRIMIDINE;4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE;4-Amino-2-(methylthio)pyrimidine-5-carboxaldehyde;4-AMino-2-(Methylthio)-5-pyriMidinecarboxaldehyde;5-PYRIMIDINECARBOXALDEHYDE, 4-AMINO-2-(METHYLTHIO)-;4-aMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde;4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde ISO 9001：2015 REACH
CBNumber: CB61090781
Molecular Formula: C6H7N3OS
Formula Weight: 169.2
MOL File: 770-31-0.mol

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4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde Property

Melting point:: 183-184 °C
Boiling point:: 379.7±27.0 °C(Predicted)
Density: 1.37
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.50±0.10(Predicted)
form: solid
color: White
InChI: InChI=1S/C6H7N3OS/c1-11-6-8-2-4(3-10)5(7)9-6/h2-3H,1H3,(H2,7,8,9)
InChIKey: FGONQMFYFJRAIG-UHFFFAOYSA-N
SMILES: C1(SC)=NC=C(C=O)C(N)=N1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: A618265
Product name: 4-Amino-2-(methylthio)pyrimidine-5-carboxaldehyde
Packaging: 50mg
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: OR918031
Product name: 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde
Purity: 98%
Packaging: 5g
Price: $157
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H66-1-6E
Product name: 4-Amino-2-(methylsulfanyl)pyrimidine-5-carbaldehyde
Purity: 97.0%
Packaging: 250mg
Price: $190
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA139504
Product name: 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde
Packaging: 2g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: J94485
Product name: 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde
Packaging: 250mg
Price: $20
Updated: 2021/12/16

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4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde Chemical Properties,Usage,Production

Uses

4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde can be used for the preparation of pyridopyrimidines and naphthyridines as inhibitors of Akt kinase for the treatment of cancer.

Synthesis

588-36-3

770-31-0

Method A: Manganese dioxide (MnO2, 49.8 g, 572 mmol) was added to a chloroform (818 mL) suspension of 4-amino-2-(methylthio)pyrimidin-5-ylmethanol (28 g, 164 mmol), and the reaction mixture was stirred for 4 hours at 55°C (internal temperature). After completion of the reaction, the reaction mixture was filtered while hot and the filter cake was washed with hot chloroform and tetrahydrofuran (THF). The filtrates were combined, concentrated under reduced pressure and subsequently dried under vacuum to afford 4-amino-2-methylmercaptopyrimidine-5-carbaldehyde (26.7 g, 96% yield) as a light yellow solid. Mass spectrometry (MS) data: m/z 170.1 ([M+H]+).

References

[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 24, p. 4606 - 4616
[2] Patent: WO2013/134243, 2013, A1. Location in patent: Page/Page column 17
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 10, p. 4165 - 4179
[4] Patent: WO2014/182829, 2014, A1. Location in patent: Page/Page column 42
[5] Patent: WO2016/191172, 2016, A1. Location in patent: Page/Page column 57

4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde Suppliers

Canada 2 China 155 India 2 United Kingdom 1 United States 8 Global 168

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View Lastest Price from 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde 770-31-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-amino-2-methylsulfanyl-pyrimidine-5-carbaldehyde 770-31-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-amino-2-methylsulfanyl-pyrimidine-5-carbaldehyde 770-31-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

770-31-0, 4-Amino-2-(methylthio)pyrimidine-5-carbaldehydeRelated Search:

4-Iodo-2-methylpyridine 2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR 4-CHLORO-6-ETHYLTHIENO[2,3-D]PYRIMIDINE 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-6-methyl- ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate 4-AMINO-5-CARBOXY-2-ETHYL-MERCAPTOPYRIMIDINE Pyrimidine-5-carboxaldehyde {[4-AMINO-5-(ETHOXYCARBONYL)PYRIMIDIN-2-YL]THIO}ACETIC ACID ETHYL 4-(4-CHLOROANILINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(METHYLAMINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE ETHYL 4-(BENZYLAMINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE ETHYL 2-(METHYLSULFANYL)-4-MORPHOLINO-5-PYRIMIDINECARBOXYLATE ETHYL 2-(METHYLSULFANYL)-4-PIPERIDINO-5-PYRIMIDINECARBOXYLATE ETHYL 4-(3,4-DICHLOROANILINO)-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE RARECHEM AL FB 0074 4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID

4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBALDEHYDE

4-aMino-2-Methanesulfanyl-pyriMidine-5-carboxaldehyde

4-AMino-2-(Methylthio)-5-pyriMidinecarboxaldehyde

4-Amino-2-(methylthio)pyrimidine-5-carboxaldehyde

2-METHYLTHIO 4-AMINO 5-FORMYL PYRIMIDINE

5-PYRIMIDINECARBOXALDEHYDE, 4-AMINO-2-(METHYLTHIO)-

4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde ISO 9001：2015 REACH

Benzene,1-ethenyl-8-nitro-

770-31-0

7770-31-0

Amines

Aromatics

Heterocycles

Sulfur & Selenium Compounds