3,4-Dichlorobenzyl bromide
- Product Name
- 3,4-Dichlorobenzyl bromide
- CAS No.
- 18880-04-1
- Chemical Name
- 3,4-Dichlorobenzyl bromide
- Synonyms
- TIMTEC-BB SBB005763;3,4-Dichlorobenzyl b;Adenosine Impurity 41;3,4-DICHLOROBENZYL BROMIDE;à-bromo-3,4-dichlorotoluene;α-Bromo-3,4-dichlorotoluene;3,4-Dichlorobenzylbromide97%;3,4-DichlorobenzylBromide>Toluene, α-bromo-3,4-dichloro-;3,4-Dichlorobenzyl bromide 97%
- CBNumber
- CB6110165
- Molecular Formula
- C7H5BrCl2
- Formula Weight
- 239.92
- MOL File
- 18880-04-1.mol
3,4-Dichlorobenzyl bromide Property
- Melting point:
- 19 °C
- Boiling point:
- 115-120 °C (1 mmHg)
- Density
- 1.650
- refractive index
- 1.605-1.607
- Flash point:
- 110 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Liquid
- color
- Clear colorless to brown
- Water Solubility
- Insoluble in water.
- Sensitive
- Lachrymatory
- BRN
- 742579
- CAS DataBase Reference
- 18880-04-1(CAS DataBase Reference)
Safety
- Hazard Codes
- C,T,N
- Risk Statements
- 34-22
- Safety Statements
- 45-36/37/39-25-61-26
- RIDADR
- 1760
- WGK Germany
- 3
- Hazard Note
- Toxic/Corrosive/Lachrymatory
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 681997
- Product name
- 3,4-Dichlorobenzyl bromide
- Purity
- 97%
- Packaging
- 1g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- D3700
- Product name
- 3,4-Dichlorobenzyl Bromide
- Packaging
- 5G
- Price
- $78
- Updated
- 2025/07/31
- Product number
- D3700
- Product name
- 3,4-Dichlorobenzyl Bromide
- Packaging
- 25G
- Price
- $151
- Updated
- 2025/07/31
- Product number
- D436523
- Product name
- 3,4-Dichlorobenzyl Bromide
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 1700-D-X1
- Product name
- 3,4-Dichlorobenzyl Bromide
- Purity
- 97%
- Packaging
- 100g
- Price
- $112
- Updated
- 2021/12/16
3,4-Dichlorobenzyl bromide Chemical Properties,Usage,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
3,4-Dichlorobenzyl bromide is used as a pharmaceutical intermediate. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
95-75-0
18880-04-1
General procedure for the synthesis of 3,4-dichlorobenzyl bromide from 3,4-dichlorotoluene: In a reaction flask equipped with a stirrer, a reflux condenser, a thermometer, and an off-gas absorption device, 3,4-dichlorotoluene (6.4 g, 40 mmol), sodium bromate (2.5 g, 16.7 mmol), sodium bromide (3.5 g, 33.6 mmol), and 1,2-dichloroethane ( 30 mL). After heating to reflux, 1/3 of the total volume of the initiator solution (0.05 g AIBN and 0.05 g BPO dissolved in 10 mL of 1,2-dichloroethane) was added rapidly. Subsequently, sulfuric acid was added slowly and dropwise (2.5 g of concentrated sulfuric acid diluted with 2.5 mL of water, equivalent to 25.2 mmol). After the dropwise addition was completed, the remaining initiator solution was used for gas chromatographic analysis. After the reaction was completed, the reaction mixture was cooled to room temperature. Saturated sodium bisulfite solution (10 mL) was added, stirred until the red color faded, and left to stratify. The organic phase was separated and the aqueous phase was extracted twice with 1,2-dichloroethane (10 mL x 2). The organic phases were combined, washed with saturated sodium chloride solution, dried and concentrated. The crude product was purified by column chromatography (eluent was petroleum ether) to give 7.7 g of 3,4-dichlorobenzyl bromide in 81% yield. The product was a colorless liquid.
References
[1] Patent: CN107098791, 2017, A. Location in patent: Paragraph 0046-0048
[2] Tetrahedron, 1998, vol. 54, # 12, p. 2953 - 2966
[3] Chinese Chemical Letters, 2011, vol. 22, # 4, p. 382 - 384
[4] Il Farmaco; edizione scientifica, 1970, vol. 25, # 6, p. 409 - 421
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 53, # 1-4, p. 43 - 67
3,4-Dichlorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-Dichlorobenzyl bromide manufacturers
- Product
- 3,4-Dichlorobenzyl bromide 18880-04-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21
- Product
- 3,4-Dichlorobenzyl bromide 18880-04-1
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 3,4-Dichlorobenzyl bromide 18880-04-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-30