ChemicalBook > CAS DataBase List > SUBSTANCE P

SUBSTANCE P

Product Name
SUBSTANCE P
CAS No.
12769-48-1
Chemical Name
SUBSTANCE P
Synonyms
RPKPQFFGLM;SUBSTANCE P;RPKPQQFFGLM-NH2;SUBSTANCE P AMIDE;SUBSTANCE P (TYR8);SUBSTANCE P BOVINE;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
CBNumber
CB6114259
Molecular Formula
C63H98N18O13S
Formula Weight
1347.63
MOL File
12769-48-1.mol
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SUBSTANCE P Property

storage temp. 
-20°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J66954
Product name
Substance P
Purity
reversed sequence
Packaging
5mg
Price
$87.7
Updated
2021/12/16
Tocris
Product number
1156
Product name
Substance P
Packaging
5
Price
$163
Updated
2021/12/16
Usbiological
Product number
242082
Product name
Substance P
Packaging
100mg
Price
$269
Updated
2021/12/16
Usbiological
Product number
S8000-14J
Product name
Substance P [D-Arg1, D-Pro2, D-Trp7,9, Leu11]
Packaging
5mg
Price
$336
Updated
2021/12/16
Usbiological
Product number
S8000-15A
Product name
Substance P
Packaging
1mg
Price
$489
Updated
2021/12/16
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SUBSTANCE P Chemical Properties,Usage,Production

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

Mechanism of action

Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.

Clinical Use

The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Preparation Products

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SUBSTANCE P Suppliers

China 13 France 1 Germany 2 Japan 4 Switzerland 1 United Kingdom 2 United States 12 Global 35
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42959
Advantage
64
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5502
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9978
Advantage
55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
6757
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10522
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921
Email
sales1@gotopbio.com
Country
CHINA
ProdList
2609
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6445
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
02961856358 15829046862
Email
1035@dideu.com
Country
China
ProdList
10011
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48465
Advantage
58
Shanghai Hanhong Chemical Co., Ltd
Tel
--
Fax
--
Email
info@hanhonggroup.com
Country
China
ProdList
3944
Advantage
67
Binhai Hanhong Biochemical Co., Ltd
Tel
--
Fax
--
Email
2355241815@qq.com
Country
China
ProdList
3449
Advantage
54
Advanced Technology & Industrial Co., Ltd.
Tel
--
Fax
--
Email
sales@advtechind.com
Country
China
ProdList
6531
Advantage
75

12769-48-1, SUBSTANCE PRelated Search:

H-GLY-LEU-MET-NH2 HCL ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-GLY-LYS-ARG SUBSTANCE P MET-LEU-GLY-PHE-PHE-GLN-GLN-PRO-LYS-PRO-ARG-NH2 SUBSTANCE P (7-11) GLY-LEU-MET-NH2 SUBSTANCE P FRAGMENT 8-11 ACETATE SALT REICHSTEIN'S SUBSTANCE 'G',REICHSTEIN'S SUBSTANCE G REICHSTEIN'S SUBSTANCE ''S'',REICHSTEIN'S SUBSTANCE S,REICHSTEIN'S SUBSTANCE 'S' REICHSTEIN'S SUBSTANCE ''H'',REICHSTEIN'S SUBSTANCE H,REICHSTEIN'S SUBSTANCE 'H' REICHSTEIN'S SUBSTANCE M,REICHSTEIN'S SUBSTANCE 'M' REICHSTEIN'S SUBSTANCE S 21-ACETATE REICHSTEIN'S SUBSTANCE 'FA',REICHSTEIN'S SUBSTANCE FA REICHSTEIN'S SUBSTANCE Q REICHSTEIN'S SUBSTANCE 'J',REICHSTEIN'S SUBSTANCE O,REICHSTEIN'S SUBSTANCE ''J'' REICHSTEIN'S SUBSTANCE 'S' 21-ACETATE 3-ETHYLENEKETAL REICHSTEIN'S SUBSTANCE ''C''

  • RPKPQQFFGLM-NH2
  • RPKPQFFGLM
  • SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE)
  • SUBSTANCE P BOVINE
  • SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11]
  • SUBSTANCE P AMIDE
  • SUBSTANCE P
  • SUBSTANCE P (TYR8)
  • H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
  • H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
  • ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
  • 12769-48-1
  • Peptides
  • Tachykinins
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • Agonist
  • BioChemical