ChemicalBook > CAS DataBase List > SUBSTANCE P

SUBSTANCE P

Product Name
SUBSTANCE P
CAS No.
12769-48-1
Chemical Name
SUBSTANCE P
Synonyms
RPKPQFFGLM;SUBSTANCE P;RPKPQQFFGLM-NH2;SUBSTANCE P AMIDE;SUBSTANCE P (TYR8);SUBSTANCE P BOVINE;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
CBNumber
CB6114259
Molecular Formula
C63H98N18O13S
Formula Weight
1347.63
MOL File
12769-48-1.mol
More
Less

SUBSTANCE P Property

storage temp. 
-20°C
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
J66954
Product name
Substance P
Purity
reversed sequence
Packaging
5mg
Price
$87.7
Updated
2021/12/16
Tocris
Product number
1156
Product name
Substance P
Packaging
5
Price
$163
Updated
2021/12/16
Usbiological
Product number
242082
Product name
Substance P
Packaging
100mg
Price
$269
Updated
2021/12/16
Usbiological
Product number
S8000-14J
Product name
Substance P [D-Arg1, D-Pro2, D-Trp7,9, Leu11]
Packaging
5mg
Price
$336
Updated
2021/12/16
Usbiological
Product number
S8000-15A
Product name
Substance P
Packaging
1mg
Price
$489
Updated
2021/12/16
More
Less

SUBSTANCE P Chemical Properties,Usage,Production

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

Mechanism of action

Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.

Clinical Use

The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SUBSTANCE P Suppliers

PolyPeptide Laboratories GmbH
Tel
--
Fax
--
Email
info@polypeptide.de
Country
Germany
ProdList
408
Advantage
66
BIOTREND Chemikalien GmbH
Tel
--
Fax
--
Email
jaeger@biotrend.com
Country
Germany
ProdList
6115
Advantage
76