PSEUDOLARIC ACID B
- Product Name
- PSEUDOLARIC ACID B
- CAS No.
- 82508-31-4
- Chemical Name
- PSEUDOLARIC ACID B
- Synonyms
- PLAB;Pseudolaric acid;Pseudolarix acid B;PSEUDOLARIC ACID B;Pseudolaric acid B-RM;(-)-Pseudolaric Acid B;Pseudolaric Acid B(PBA);7-Di-O-methylnaringenin;Pseudolaric Acid B (PAB);Pseudolaric Acid B, 10 mM in DMSO
- CBNumber
- CB6117700
- Molecular Formula
- C23H28O8
- Formula Weight
- 432.46
- MOL File
- 82508-31-4.mol
PSEUDOLARIC ACID B Property
- Melting point:
- 166°C
- Boiling point:
- 466.14°C (rough estimate)
- Density
- 1.2108 (rough estimate)
- refractive index
- 1.4480 (estimate)
- storage temp.
- 2-8°C
- solubility
- methanol: soluble1mg/mL, clear, colorless
- form
- powder or crystals
- pka
- 4.52±0.19(Predicted)
- color
- white to off-white
- InChIKey
- VDGOFNMYZYBUDT-YCONPBHISA-N
- SMILES
- C1(=O)O[C@@](/C=C/C=C(/C(O)=O)\C)(C)[C@]2([H])CC[C@@]31CC=C(C(OC)=O)CC[C@@]32OC(C)=O
Safety
- Hazard Codes
- T
- Risk Statements
- 25-62
- Safety Statements
- 36/37-45-24/25
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- HS Code
- 29329990
- Hazardous Substances Data
- 82508-31-4(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- L8170
- Product name
- Pseudolaric Acid B
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $725
- Updated
- 2023/06/20
- Product number
- L8170
- Product name
- Pseudolaric Acid B
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $164
- Updated
- 2023/01/07
- Product number
- 13527
- Product name
- Pseudolaric Acid B
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 13527
- Product name
- Pseudolaric Acid B
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 13527
- Product name
- Pseudolaric Acid B
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $341
- Updated
- 2024/03/01
PSEUDOLARIC ACID B Chemical Properties,Usage,Production
Description
Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.
Chemical Properties
White crystalline powder, soluble in chloroform, acetone and methanol, derived from the bark of the Chinese thorn tree and the golden pine.
Uses
(-)-Pseudolaric Acid B is a diterpenoid posessing an immunomodulatory effect. It acts as an immunosuppressant in vitro/vivo however does show some cytotoxicity. Anti-tumor agent as well.
Definition
ChEBI: Pseudolaric acid B is a diterpene lactone.
in vivo
Pseudolaric Acid B (Oral gavage; 10-20 mg/kg; 3 days) has anti-fertility ability in rats, which may be related to the maternal vascular system[4].
IC 50
HIF-1α
References
[1] ERGUANG LI Charles D H Alice M Clark. Antifungal Evaluation of Pseudolaric Acid B, a Major Constituent of Pseudolarix kaempferi[J]. Journal of Natural Products , 1995, 58 1: 57-67. DOI: 10.1021/np50115a007
[2] XIANFENG GONG. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death[J]. Experimental and Molecular Medicine, 2006, 38 4: 428-434. DOI: 10.1038/emm.2006.50
[3] VINCENT K W WONG. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.[J]. Clinical Cancer Research, 2005, 11 16: 6002-6011. DOI: 10.1158/1078-0432.ccr-05-0209
[4] MEI-HONG LI. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation.[J]. Clinical Cancer Research, 2004, 10 24: 8266-8274. DOI: 10.1158/1078-0432.ccr-04-0951
PSEUDOLARIC ACID B Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PSEUDOLARIC ACID B manufacturers
- Product
- Pseudolaric acid B 82508-31-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- Pseudolaric Acid B 82508-31-4
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-02-25
- Product
- PSEUDOLARIC ACID B 82508-31-4
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10000kg
- Release date
- 2018-08-10