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PSEUDOLARIC ACID B

Product Name
PSEUDOLARIC ACID B
CAS No.
82508-31-4
Chemical Name
PSEUDOLARIC ACID B
Synonyms
PLAB;Pseudolaric acid;Pseudolarix acid B;PSEUDOLARIC ACID B;Pseudolaric acid B-RM;(-)-Pseudolaric Acid B;Pseudolaric Acid B(PBA);7-Di-O-methylnaringenin;Pseudolaric Acid B (PAB);Pseudolaric Acid B, 10 mM in DMSO
CBNumber
CB6117700
Molecular Formula
C23H28O8
Formula Weight
432.46
MOL File
82508-31-4.mol
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PSEUDOLARIC ACID B Property

Melting point:
166°C
Boiling point:
466.14°C (rough estimate)
Density 
1.2108 (rough estimate)
refractive index 
1.4480 (estimate)
storage temp. 
2-8°C
solubility 
methanol: soluble1mg/mL, clear, colorless
form 
powder or crystals
pka
4.52±0.19(Predicted)
color 
white to off-white
InChIKey
VDGOFNMYZYBUDT-YCONPBHISA-N
SMILES
C1(=O)O[C@@](/C=C/C=C(/C(O)=O)\C)(C)[C@]2([H])CC[C@@]31CC=C(C(OC)=O)CC[C@@]32OC(C)=O
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Safety

Hazard Codes 
T
Risk Statements 
25-62
Safety Statements 
36/37-45-24/25
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
29329990
Hazardous Substances Data
82508-31-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L8170
Product name
Pseudolaric Acid B
Purity
≥98% (HPLC)
Packaging
10mg
Price
$725
Updated
2023/06/20
Sigma-Aldrich
Product number
L8170
Product name
Pseudolaric Acid B
Purity
≥98% (HPLC)
Packaging
1mg
Price
$164
Updated
2023/01/07
Cayman Chemical
Product number
13527
Product name
Pseudolaric Acid B
Purity
≥98%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
13527
Product name
Pseudolaric Acid B
Purity
≥98%
Packaging
1mg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
13527
Product name
Pseudolaric Acid B
Purity
≥98%
Packaging
5mg
Price
$341
Updated
2024/03/01
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PSEUDOLARIC ACID B Chemical Properties,Usage,Production

Description

Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.

Chemical Properties

White crystalline powder, soluble in chloroform, acetone and methanol, derived from the bark of the Chinese thorn tree and the golden pine.

Uses

(-)-Pseudolaric Acid B is a diterpenoid posessing an immunomodulatory effect. It acts as an immunosuppressant in vitro/vivo however does show some cytotoxicity. Anti-tumor agent as well.

Definition

ChEBI: Pseudolaric acid B is a diterpene lactone.

in vivo

Pseudolaric Acid B (Oral gavage; 10-20 mg/kg; 3 days) has anti-fertility ability in rats, which may be related to the maternal vascular system[4].

IC 50

HIF-1α

References

[1] ERGUANG LI  Charles D H  Alice M Clark. Antifungal Evaluation of Pseudolaric Acid B, a Major Constituent of Pseudolarix kaempferi[J]. Journal of Natural Products , 1995, 58 1: 57-67. DOI: 10.1021/np50115a007
[2] XIANFENG GONG. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death[J]. Experimental and Molecular Medicine, 2006, 38 4: 428-434. DOI: 10.1038/emm.2006.50
[3] VINCENT K W WONG. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.[J]. Clinical Cancer Research, 2005, 11 16: 6002-6011. DOI: 10.1158/1078-0432.ccr-05-0209
[4] MEI-HONG LI. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation.[J]. Clinical Cancer Research, 2004, 10 24: 8266-8274. DOI: 10.1158/1078-0432.ccr-04-0951

PSEUDOLARIC ACID B Preparation Products And Raw materials

Raw materials

Preparation Products

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PSEUDOLARIC ACID B Suppliers

China 227 Germany 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 19 Global 250
Alexis Corporation
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
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View Lastest Price from PSEUDOLARIC ACID B manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Pseudolaric acid B 82508-31-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Shanghai Standard Technology Co., Ltd.
Product
Pseudolaric Acid B 82508-31-4
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-02-25
Career Henan Chemical Co
Product
PSEUDOLARIC ACID B 82508-31-4
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000kg
Release date
2018-08-10

82508-31-4, PSEUDOLARIC ACID BRelated Search:

NSC615487 Pseudolaric Acid C tert-Butyl trimethylacetate METHYL-CIS-4-DECENOATE ETHYL 3 ACETOXY HEXANOATE 2,4-HEXADIENYL ISOBUTYRATE ε-Caprolactone MUGUOL PSEUDOLARIC ACID B ETHYL CIS-2-HYDROXY-1-CYCLOPENTANECARBOXYLATE ETHYL 1-HYDROXYCYCLOPENTANE-CARBOXYLATE 3,3-DIMETHYL-TETRAHYDRO-PYRAN-2-ONE CIS-2-HYDROXY-1-CYCLOPENTANECARBOXYLIC ACID,99% HEX-2-ENEDIOIC ACID DIMETHYL ESTER ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOPENTANECARBOXYLATE SEBACIC ACID MONOMETHYL ESTER 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER Pseudolaric Acid B, Pseudolarix kaempferi

  • Pseudolaric acid
  • Pseudolaric Acid B (PAB)
  • Pseudolaric Acid B(PBA)
  • -1,3-pentadienyl)3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methylester,(3-al
  • 1h-4,9a-ethanocyclohepta(c)pyran-7-carboxylicacid,4a-(acetyloxy)-3-(4-carboxy
  • pha(1e,3e),4-alpha,4a-alpha,9a-alpha)-(-)-(9ci)
  • PSEUDOLARIC ACID B
  • PLAB
  • 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-
  • Pseudolarix acid B
  • Pseudolaric acid B, 98%, from Pseudolarix amabilis (J. Nelson) Rehder
  • (-)-Pseudolaric Acid B
  • (2E,4E)-5-((3R,4S,4aS,9aS)-4a-acetoxy-7-(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-1H-4,9a-ethanocyclohepta[c]pyran-3-yl)-2-methylpenta-2,4-dienoic acid
  • 7-Di-O-methylnaringenin
  • (2E,4E)-5-((3R,4S,4aS,9aR)-4a-Acetoxy-7-(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-1H-4,9a-ethanocyclohepta[c]pyran-3-yl)-2-methylpenta-2,4-dienoic acid
  • Pseudolaric acid B-RM
  • Pseudolaric Acid B, 10 mM in DMSO
  • 82508-31-4
  • C23H28O8
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors