ChemicalBook > CAS DataBase List > PSEUDOLARIC ACID B

PSEUDOLARIC ACID B

Product Name: PSEUDOLARIC ACID B
CAS No.: 82508-31-4
Chemical Name: PSEUDOLARIC ACID B
Synonyms: PLAB;Pseudolaric acid;Pseudolarix acid B;PSEUDOLARIC ACID B;Pseudolaric acid B-RM;(-)-Pseudolaric Acid B;Pseudolaric Acid B(PBA);7-Di-O-methylnaringenin;Pseudolaric Acid B (PAB);Pseudolaric Acid B, 10 mM in DMSO
CBNumber: CB6117700
Molecular Formula: C23H28O8
Formula Weight: 432.46
MOL File: 82508-31-4.mol

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PSEUDOLARIC ACID B Property

Melting point:: 166°C
Boiling point:: 466.14°C (rough estimate)
Density: 1.2108 (rough estimate)
refractive index: 1.4480 (estimate)
storage temp.: 2-8°C
solubility: methanol: soluble1mg/mL, clear, colorless
form: powder or crystals
pka: 4.52±0.19(Predicted)
color: white to off-white
InChIKey: VDGOFNMYZYBUDT-YCONPBHISA-N
SMILES: C1(=O)O[C@@](/C=C/C=C(/C(O)=O)\C)(C)[C@]2([H])CC[C@@]31CC=C(C(OC)=O)CC[C@@]32OC(C)=O

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Safety

Hazard Codes: T
Risk Statements: 25-62
Safety Statements: 36/37-45-24/25
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 29329990
Hazardous Substances Data: 82508-31-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L8170
Product name: Pseudolaric Acid B
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $725
Updated: 2023/06/20

Sigma-Aldrich

Product number: L8170
Product name: Pseudolaric Acid B
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $164
Updated: 2023/01/07

Cayman Chemical

Product number: 13527
Product name: Pseudolaric Acid B
Purity: ≥98%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 13527
Product name: Pseudolaric Acid B
Purity: ≥98%
Packaging: 1mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 13527
Product name: Pseudolaric Acid B
Purity: ≥98%
Packaging: 5mg
Price: $341
Updated: 2024/03/01

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PSEUDOLARIC ACID B Chemical Properties,Usage,Production

Description

Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC₅₀ = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.

Chemical Properties

White crystalline powder, soluble in chloroform, acetone and methanol, derived from the bark of the Chinese thorn tree and the golden pine.

Uses

(-)-Pseudolaric Acid B is a diterpenoid posessing an immunomodulatory effect. It acts as an immunosuppressant in vitro/vivo however does show some cytotoxicity. Anti-tumor agent as well.

Definition

ChEBI: Pseudolaric acid B is a diterpene lactone.

in vivo

Pseudolaric Acid B (Oral gavage; 10-20 mg/kg; 3 days) has anti-fertility ability in rats, which may be related to the maternal vascular system^[4].

IC 50

HIF-1α

References

[1] ERGUANG LI Charles D H Alice M Clark. Antifungal Evaluation of Pseudolaric Acid B, a Major Constituent of Pseudolarix kaempferi[J]. Journal of Natural Products , 1995, 58 1: 57-67. DOI: 10.1021/np50115a007
[2] XIANFENG GONG. Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death[J]. Experimental and Molecular Medicine, 2006, 38 4: 428-434. DOI: 10.1038/emm.2006.50
[3] VINCENT K W WONG. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.[J]. Clinical Cancer Research, 2005, 11 16: 6002-6011. DOI: 10.1158/1078-0432.ccr-05-0209
[4] MEI-HONG LI. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation.[J]. Clinical Cancer Research, 2004, 10 24: 8266-8274. DOI: 10.1158/1078-0432.ccr-04-0951

PSEUDOLARIC ACID B Preparation Products And Raw materials

Raw materials

Preparation Products

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PSEUDOLARIC ACID B Suppliers

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View Lastest Price from PSEUDOLARIC ACID B manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Pseudolaric acid B 82508-31-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Shanghai Standard Technology Co., Ltd.

Product: Pseudolaric Acid B 82508-31-4
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-02-25

Career Henan Chemical Co

Product: PSEUDOLARIC ACID B 82508-31-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2018-08-10

82508-31-4, PSEUDOLARIC ACID BRelated Search:

NSC615487 Pseudolaric Acid C tert-Butyl trimethylacetate METHYL-CIS-4-DECENOATE ETHYL 3 ACETOXY HEXANOATE 2,4-HEXADIENYL ISOBUTYRATE ε-Caprolactone MUGUOL PSEUDOLARIC ACID B ETHYL CIS-2-HYDROXY-1-CYCLOPENTANECARBOXYLATE ETHYL 1-HYDROXYCYCLOPENTANE-CARBOXYLATE 3,3-DIMETHYL-TETRAHYDRO-PYRAN-2-ONE CIS-2-HYDROXY-1-CYCLOPENTANECARBOXYLIC ACID,99% HEX-2-ENEDIOIC ACID DIMETHYL ESTER ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOPENTANECARBOXYLATE SEBACIC ACID MONOMETHYL ESTER 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER Pseudolaric Acid B, Pseudolarix kaempferi

Pseudolaric acid

Pseudolaric Acid B (PAB)

Pseudolaric Acid B(PBA)

-1,3-pentadienyl)3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methylester,(3-al

1h-4,9a-ethanocyclohepta(c)pyran-7-carboxylicacid,4a-(acetyloxy)-3-(4-carboxy

pha(1e,3e),4-alpha,4a-alpha,9a-alpha)-(-)-(9ci)

PSEUDOLARIC ACID B

PLAB

1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-

Pseudolarix acid B

Pseudolaric acid B, 98%, from Pseudolarix amabilis (J. Nelson) Rehder

(-)-Pseudolaric Acid B

(2E,4E)-5-((3R,4S,4aS,9aS)-4a-acetoxy-7-(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-1H-4,9a-ethanocyclohepta[c]pyran-3-yl)-2-methylpenta-2,4-dienoic acid

7-Di-O-methylnaringenin

(2E,4E)-5-((3R,4S,4aS,9aR)-4a-Acetoxy-7-(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-1H-4,9a-ethanocyclohepta[c]pyran-3-yl)-2-methylpenta-2,4-dienoic acid

Pseudolaric acid B-RM

Pseudolaric Acid B, 10 mM in DMSO

82508-31-4

C23H28O8

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors