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Lerisetron

Product Name
Lerisetron
CAS No.
143257-98-1
Chemical Name
Lerisetron
Synonyms
CID 65997;F-0930-RS;Lerisetron;Lerisetron, 10 mM in DMSO;1-benzyl-2-piperazin-1-ylbenzimidazole;1-BENZYL-2-PIPERAZIN-1-YL-1H-BENZIMIDAZOLE;1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole;1-Benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole;1H-Benzimidazole, 1-(phenylmethyl)-2-(1-piperazinyl)-;1-benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
CBNumber
CB61179015
Molecular Formula
C18H20N4
Formula Weight
292.38
MOL File
143257-98-1.mol
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Lerisetron Property

storage temp. 
Store at -20°C
solubility 
DMSO: 58 mg/mL (198.37 mM);Ethanol: 58 mg/mL (198.37 mM)
form 
Solid
color 
White to off-white
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009131
Product name
LERISETRON
Purity
95.00%
Packaging
5MG
Price
$500.83
Updated
2021/12/16
Matrix Scientific
Product number
137090
Product name
1-Benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
Purity
95%
Packaging
1g
Price
$611
Updated
2021/12/16
AK Scientific
Product number
3845CA
Product name
Lerisetron
Packaging
100mg
Price
$623
Updated
2021/12/16
Matrix Scientific
Product number
137090
Product name
1-Benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
Purity
95%
Packaging
2.500g
Price
$1334
Updated
2021/12/16
AK Scientific
Product number
3845CA
Product name
Lerisetron
Packaging
5g
Price
$1724
Updated
2021/12/16
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Lerisetron Chemical Properties,Usage,Production

Uses

Lerisetron is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats[1].

in vivo

Lerisetron (50-200 μg/kg; IV; single) exhibits CL of 0.004-0.005 L/min, Vds of 0.88-0.96 L, MRT0-LAST of 224-337.1 min and AUC∞ of 57.7-66.1 μg·min/L in rats[2].
Lerisetron (2-10 μg/kg; IV; single) causes rapid recovery from bradycardia[2].
Pharmacokinetic Parameters of Lerisetron in Sprague-Dawley rats[2].

IV (50 μg/kg)IV (100 μg/kg)IV (200 μg/kg)
CL (L/min)0.0050.0040.004
Vds (L)0.90.880.96
MRT0-LAST (min)224337.1226.3
AUC∞ (μg·min/L)66.157.758.1

References

[1] Orjales A, Mosquera R, Labeaga L, Rodes R. New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation. J Med Chem. 1997;40(4):586-593.
[2] Jauregizar N, Calvo R, Suarez E, Quintana A, Raczka E, Lukas JC. Pharmacokinetics and pharmacological effect of lerisetron, a new 5-HT3 antagonist, in rats. J Pharm Sci. 2002;91(1):41-52. DOI:10.1002/jps.1169

Lerisetron Preparation Products And Raw materials

Raw materials

Preparation Products

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Lerisetron Suppliers

China 24 United States 4 Global 28
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

143257-98-1, LerisetronRelated Search:

ONDANSETRON FOR LC SYSTEM SUITABILITY Palonosetron ALOSETRON dolasetron Dolasetron mesylate Granisetron Palonosetron Hydrochloride Palonosetron 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE 1-BENZYL-2-(4-BENZYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOLE Lerisetron 1-BENZYL-2-(4-METHYL-PIPERAZIN-1-YL)-1H-BENZOIMIDAZOLE ZERENEX EZX001545 1-BENZYL-2-(4-PHENYL-PIPERAZIN-1-YL)-1H-BENZOIMIDAZOLE

  • 1-benzyl-2-piperazin-1-ylbenzimidazole
  • F-0930-RS
  • Lerisetron
  • 1-benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
  • 1-BENZYL-2-PIPERAZIN-1-YL-1H-BENZIMIDAZOLE
  • CID 65997
  • 1H-Benzimidazole, 1-(phenylmethyl)-2-(1-piperazinyl)-
  • 5-HT Receptor,Serotonin Receptor,Serotonin,Lerisetron,Bradycardia,Inhibitor,5-hydroxytryptamine Receptor,Pharmacokinetics,inhibit,SD rats
  • 1-Benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole
  • Lerisetron, 10 mM in DMSO
  • 1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole
  • 143257-98-1
  • C18H22Cl2N4