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Seocalcitol

Product Name
Seocalcitol
CAS No.
134404-52-7
Chemical Name
Seocalcitol
Synonyms
Seocalcitol;Theocalcitriol;(1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R,3E,5E)-7-Ethyl-7-hydroxynona-3,5-dien-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol;(1R,3S,5Z)-5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol;1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-;EB 1089,(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
CBNumber
CB61179727
Molecular Formula
C30H46O3
Formula Weight
454.68
MOL File
134404-52-7.mol
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Seocalcitol Property

Melting point:
123-125°
Boiling point:
608.5±55.0 °C(Predicted)
Density 
1.06±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solid
pka
14.29±0.29(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1727
Product name
EB1089
Purity
≥98% (HPLC)
Packaging
1 mg
Price
$240
Updated
2025/07/31
Cayman Chemical
Product number
21579
Product name
EB 1089
Purity
≥98%
Packaging
500μg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
21579
Product name
EB 1089
Purity
≥98%
Packaging
1mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
21579
Product name
EB 1089
Purity
≥98%
Packaging
5mg
Price
$773
Updated
2024/03/01
TRC
Product number
E320200
Product name
EB1089
Packaging
10mg
Price
$1105
Updated
2021/12/16
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Seocalcitol Chemical Properties,Usage,Production

Description

EB 1089 is a synthetic vitamin D analog that is 50-200 times more potent than calcitriol at inhibiting cell proliferation and differentiation, yet displays reduced calcemic activity compared to that of calcitriol. It has been shown to promote tumor regression in vitro by inducing apoptosis.

Uses

EB 1089 is an analogue of Calcitriol (C144500), which is a biologically active form of Vitamin D3 (1). It can be used in androgen receptor-targeted therapy research for breast cancer (2). EB 1089 exhibits anti-cancer properties.

in vivo

Seocalcitol (EB1089), a synthetic vitamin D analog, exhibits reduced hypercalcemic activity relative to 1,25(OH)2VD3. In another study, long-term intraperitoneal (IP) administration of Seocalcitol at a dose of 0.5 μg/kg body weight every other day in C3H/Sy mice exertes a very strong inhibitory effect on hepatocellular carcinoma (HCC) development[4]. Seocalcitol (EB 1089) is administered daily to postnatal rats from 4 to 12 days of age (P4 to P12) by intraperitoneal injection at either 0.38 or 1.25 μg/kg body weight (BW)/day. Only the highest dose of Seocalcitol (1.25 μg/kg BW) causes a significant reduction in weight gain when administered alone or in conjunction with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid[5].

References

[1] C M HANSEN. Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation.[J]. Current pharmaceutical design, 2000, 6 7: 803-828. DOI: 10.2174/1381612003400371
[2] S Y JAMES. EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro.[J]. British Journal of Pharmacology, 1998, 125 5: 953-962. DOI: 10.1038/sj.bjp.0702103

Seocalcitol Preparation Products And Raw materials

Raw materials

Preparation Products

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Seocalcitol Suppliers

China 91 United Kingdom 1 United States 12 Global 104
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
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57
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
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62
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
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55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Hydragon Pharma Ltd
Tel
021-50215258
Fax
021-50215756
Email
market@hypharma.com
Country
China
ProdList
321
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
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View Lastest Price from Seocalcitol manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Seocalcitol 134404-52-7
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99.0%min. HPLC
Supply Ability
10000
Release date
2024-09-21
Career Henan Chemical Co
Product
Seocalcitol 134404-52-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13

134404-52-7, SeocalcitolRelated Search:

Vitamin D3 (5R)-ethyl 5-((1R,3aS,7aR)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldiMethylsilyloxy)-2-Methylenecyclohexylidene)ethyl)-7a-Methyloctahydro-1H-inden-1-yl)hexanoate FALECALCITRIOL N,5-bis(4-chlorophenyl)-3-iMino-3,5-dihydrophenazin-2-aMine 5-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-hexanoic acid ethyl ester methylene calcitriol Paricalcitol Alfacalcidol ELOCALCITOL INECALCITOL Lexacalcitol Seocalcitol

  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
  • Seocalcitol
  • (1R,3S,5Z)-5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol
  • EB 1089,(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
  • 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-
  • (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R,3E,5E)-7-Ethyl-7-hydroxynona-3,5-dien-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
  • Theocalcitriol
  • 134404-52-7