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1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)-

Product Name
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)-
CAS No.
1995025-05-2
Chemical Name
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)-
Synonyms
ZINC194100678;ZINC194100678, 10 mM in DMSO;N-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)-
CBNumber
CB612248160
Molecular Formula
C10H13N5O
Formula Weight
219.24
MOL File
1995025-05-2.mol
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1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- Property

Boiling point:
479.2±45.0 °C(Predicted)
Density 
1.418±0.06 g/cm3(Predicted)
pka
10.83±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- Chemical Properties,Usage,Production

Uses

ZINC194100678 is a potent PAK1 inhibitor with an IC50 value of 8.37 μM. ZINC194100678 can inhibit MDA-MB-231 cell proliferation. ZINC194100678 can be used for researching anticancer[1].

IC 50

PAK1: 8.37 μM (IC50)

References

[1] Zhang J, et al. Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells. Eur J Med Chem. 2020;194:112220. DOI:10.1016/j.ejmech.2020.112220

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- Suppliers

China 12 United States 1 Global 13
Shanghai Beckham Medical Technology Co., Ltd
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Bide Pharmatech Ltd.
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400-1647117 13681763483
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Shanghai Yifei Biotechnology Co. , Ltd.
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TargetMol Chemicals Inc.
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
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Sangon Biotech (Shanghai) Co.,Ltd.
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Guangzhou Weisheng Biotechnology Co., Ltd.
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Absin Bioscience Inc.
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Proteintech China
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1995025-05-2, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)-Related Search:

4-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-5-[4-(pentyloxy)phenyl]-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one ZINC03129319 (R)-ZINC-3573 ((R)-ZINC3573) 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- 1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine 3,4-dihydro-1H-isoquinolin-2-yl-[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]methanone ZINC13466751 2-(2-oxobenzo[cd]indol-1(2H)-yl)-N-[2-(trifluoromethyl)phenyl]acetamide 6-(3,4-dimethoxyphenyl)-3-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 6-(3,4-dimethoxyphenyl)-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 4(1H)-Quinazolinone, 2,3-dihydro-3-(2-thiazolylmethyl)-2-thioxo- FMOC-THR(GALNAC(AC)3-ALPHA-D)-OH ZINC36617540 N-(4,5-dihydronaphtho[1,2-d]thiazol-2-yl)-2-(3,4-dimethoxyphenyl)acetamide 1-(2-(4-(4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-yl)-3-hydroxyphenoxy)ethyl)piperidine-4-carboxamide 1-(2-(3-hydroxy-4-(4-phenyl-1H-pyrazol-3-yl)phenoxy)ethyl)piperidine-4-carboxamide 2H-1-Benzopyran-2-one, 3-[2-[(3-acetylphenyl)amino]-4-thiazolyl]-

  • 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)-
  • ZINC194100678
  • N-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • ZINC194100678, 10 mM in DMSO
  • 1995025-05-2