ChemicalBook > CAS DataBase List > 2-Fluoro-5-(trifluoromethyl)aniline

2-Fluoro-5-(trifluoromethyl)aniline

Product Name: 2-Fluoro-5-(trifluoromethyl)aniline
CAS No.: 535-52-4
Chemical Name: 2-Fluoro-5-(trifluoromethyl)aniline
Synonyms: uoro-5-(trifL;α,α,α,6-Tetrafluoro-m-toluidine;3-AMINO-4-FLUOROBENZOTRIFLUORIDE;4-FLUORO-3-AMINOBENZOTRIFLUORIDE;3－amino－4－fluorobentozrifluoride;3-amino-4-fluoro bensotrifluoride;2-FLUORO-5-(TRIFLUOROMETHYL)ANILINE;3-Amino-4-fluorobenzotrifluoride97%;4-FLUORO-3-AMINOBENZOTRIFLUORIDE 97%;3-Amino-4-fluorobenzotrifluoride 97%
CBNumber: CB6123639
Molecular Formula: C7H5F4N
Formula Weight: 179.11
MOL File: 535-52-4.mol

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2-Fluoro-5-(trifluoromethyl)aniline Property

Boiling point:: 155 °C (lit.)
Density: 1.378 g/mL at 25 °C (lit.)
refractive index: n20/D 1.461(lit.)
Flash point:: 158 °F
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform, Methanol
pka: 1.98±0.10(Predicted)
form: Oil
color: Clear Colourless
Specific Gravity: 1.378
BRN: 1950800
InChI: InChI=1S/C7H5F4N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2
InChIKey: DRKWGMXFFCPZLW-UHFFFAOYSA-N
SMILES: C1(N)=CC(C(F)(F)F)=CC=C1F
CAS DataBase Reference: 535-52-4(CAS DataBase Reference)
NIST Chemistry Reference: Alpha,alpha,alpha,6-tetrafluoro-m-toluidine(535-52-4)

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Safety

Hazard Codes: Xn,Xi,T
Risk Statements: 20/21/22-36/37/38-23-21/22
Safety Statements: 26-36/37-45-36/37/39
RIDADR: UN2810/6.1/II
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 285056
Product name: 2-Fluoro-5-(trifluoromethyl)aniline
Purity: 97%
Packaging: 5g
Price: $33.8
Updated: 2023/06/20

TCI Chemical

Product number: A1582
Product name: 3-Amino-4-fluorobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 5g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: A1582
Product name: 3-Amino-4-fluorobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 25g
Price: $65
Updated: 2025/07/31

TRC

Product number: F596095
Product name: 2-Fluoro-5-(trifluoromethyl)aniline
Packaging: 100g
Price: $360
Updated: 2021/12/16

TRC

Product number: F596095
Product name: 2-Fluoro-5-(trifluoromethyl)aniline
Packaging: 5g
Price: $60
Updated: 2021/12/16

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2-Fluoro-5-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

clear yellow to orange liquid

Uses

2-Fluoro-5-(trifluoromethyl)aniline may be used in chemical synthesis studies.

Synthesis

367-86-2

7439-89-6

535-52-4

General procedure for the synthesis of 2-fluoro-5-trifluoromethylaniline from 2-nitro-4-trifluoromethylfluorobenzene and iron powder: Referring to Example 1, 2-fluoro-5-trifluoromethylaniline was prepared as follows: 20 g of 3-nitro-4-fluorobenzotrifluoride was dissolved in 50 mL of methanol. Under stirring conditions, 16 g of iron powder was slowly added and concentrated hydrochloric acid was added dropwise. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, an appropriate amount of sodium bicarbonate was added to neutralize the reaction solution. Subsequently, ether was added for extraction and the insoluble material was removed by filtration using diatomaceous earth. The ether phase was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 14 g of the target product 2-fluoro-5-trifluoromethylaniline in 82% yield.

References

[1] Patent: EP1243584, 2002, A1

2-Fluoro-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Fluoro-5-(trifluoromethyl)aniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Fluoro-5-(trifluoromethyl)aniline 535-52-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Hebei Fengjia New Material Co., Ltd

Product: 2-Fluoro-5-(trifluoromethyl)aniline 535-52-4
Price: US $120.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000000
Release date: 2024-08-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Fluoro-5-(trifluoromethyl)aniline 535-52-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

535-52-4, 2-Fluoro-5-(trifluoromethyl)anilineRelated Search:

6-Aminocaproic acid Glycine 2-Fluoro-5-trifluoromethylpyridine N,N-Dimethylaniline N-Methylaniline (Trifluoromethyl)trimethylsilane 3-Aminophenol 3,3',5,5'-Tetramethylbenzidine dihydrochloride 2-Aminobenzotrifluoride ALTRENOGEST o-Toluidine Aniline 3-Aminobenzotrifluoride N,N-Dimethyl-1,4-phenylenediamine 2,4,5-Trifluoroaniline 4-Aminobenzotrifluoride Acid Blue 93 Tris(hydroxymethyl)aminomethane

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3-Amino-4-fluorobenzotrifluoride97%

4-FLUORO-3-AMINOBENZOTRIFLUORIDE 97%

3-amino-4-fluorotrifluoromethylbenzene

3-Amino-4-fluorobenzotrifluoride, α,α,α,6-Tetrafluoro-m-toluidine

3-amino-4-fluoro bensotrifluoride

2-Fluoro-5-(trifluoromethyl)aniline,97%

α,α,α,6-Tetrafluoro-m-toluidine

3－amino－4－fluorobentozrifluoride

2-fluoro-5-(trifluoromethyl)aniline(SALTDATA: FREE)

[2-fluoro-5-(trifluoromethyl)phenyl]amine

2-Fluoro-5-(trifluoromethyl)aniline, alpha,alpha,alpha,6-Tetrafluoro-m-toluidine

3-Amino-4-fluorobenzotrifluoride &gt

uoro-5-(trifL

Benzenamine, 2-fluoro-5-(trifluoromethyl)-

535-52-4

H2NC6H3FCF3

Nitrogen Compounds

Organic Building Blocks

Amines

Building Blocks

Miscellaneous

Aniline

Anilines, Aromatic Amines and Nitro Compounds

Trifluoromethylbenzene serise

bc0001