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2-Fluoro-5-(trifluoromethyl)aniline

Product Name
2-Fluoro-5-(trifluoromethyl)aniline
CAS No.
535-52-4
Chemical Name
2-Fluoro-5-(trifluoromethyl)aniline
Synonyms
uoro-5-(trifL;α,α,α,6-Tetrafluoro-m-toluidine;3-AMINO-4-FLUOROBENZOTRIFLUORIDE;4-FLUORO-3-AMINOBENZOTRIFLUORIDE;3－amino－4－fluorobentozrifluoride;3-amino-4-fluoro bensotrifluoride;2-FLUORO-5-(TRIFLUOROMETHYL)ANILINE;3-Amino-4-fluorobenzotrifluoride97%;4-FLUORO-3-AMINOBENZOTRIFLUORIDE 97%;3-Amino-4-fluorobenzotrifluoride 97%
CBNumber
CB6123639
Molecular Formula
C7H5F4N
Formula Weight
179.11
MOL File
535-52-4.mol
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2-Fluoro-5-(trifluoromethyl)aniline Property

Boiling point:
155 °C (lit.)
Density 
1.378 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.461(lit.)
Flash point:
158 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform, Methanol
pka
1.98±0.10(Predicted)
form 
Oil
color 
Clear Colourless
Specific Gravity
1.378
BRN 
1950800
InChI
InChI=1S/C7H5F4N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2
InChIKey
DRKWGMXFFCPZLW-UHFFFAOYSA-N
SMILES
C1(N)=CC(C(F)(F)F)=CC=C1F
CAS DataBase Reference
535-52-4(CAS DataBase Reference)
NIST Chemistry Reference
Alpha,alpha,alpha,6-tetrafluoro-m-toluidine(535-52-4)
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Safety

Hazard Codes 
Xn,Xi,T
Risk Statements 
20/21/22-36/37/38-23-21/22
Safety Statements 
26-36/37-45-36/37/39
RIDADR 
UN2810/6.1/II
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
285056
Product name
2-Fluoro-5-(trifluoromethyl)aniline
Purity
97%
Packaging
5g
Price
$33.8
Updated
2023/06/20
TCI Chemical
Product number
A1582
Product name
3-Amino-4-fluorobenzotrifluoride
Purity
>98.0%(GC)
Packaging
5g
Price
$23
Updated
2025/07/31
TCI Chemical
Product number
A1582
Product name
3-Amino-4-fluorobenzotrifluoride
Purity
>98.0%(GC)
Packaging
25g
Price
$65
Updated
2025/07/31
TRC
Product number
F596095
Product name
2-Fluoro-5-(trifluoromethyl)aniline
Packaging
5g
Price
$60
Updated
2021/12/16
TRC
Product number
F596095
Product name
2-Fluoro-5-(trifluoromethyl)aniline
Packaging
100g
Price
$360
Updated
2021/12/16
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2-Fluoro-5-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

clear yellow to orange liquid

Uses

2-Fluoro-5-(trifluoromethyl)aniline may be used in chemical synthesis studies.

Synthesis

367-86-2

7439-89-6

535-52-4

General procedure for the synthesis of 2-fluoro-5-trifluoromethylaniline from 2-nitro-4-trifluoromethylfluorobenzene and iron powder: Referring to Example 1, 2-fluoro-5-trifluoromethylaniline was prepared as follows: 20 g of 3-nitro-4-fluorobenzotrifluoride was dissolved in 50 mL of methanol. Under stirring conditions, 16 g of iron powder was slowly added and concentrated hydrochloric acid was added dropwise. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, an appropriate amount of sodium bicarbonate was added to neutralize the reaction solution. Subsequently, ether was added for extraction and the insoluble material was removed by filtration using diatomaceous earth. The ether phase was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 14 g of the target product 2-fluoro-5-trifluoromethylaniline in 82% yield.

References

[1] Patent: EP1243584, 2002, A1

2-Fluoro-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-5-(trifluoromethyl)aniline Suppliers

Americas 1 Canada 2 China 251 Europe 3 France 1 Germany 4 India 3 Italy 1 Japan 2 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 17 United States 39 Global 328
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
ecochem international chemical broker
Tel
--
Fax
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Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
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Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from 2-Fluoro-5-(trifluoromethyl)aniline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Fluoro-5-(trifluoromethyl)aniline 535-52-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-07-01
Hebei Fengjia New Material Co., Ltd
Product
2-Fluoro-5-(trifluoromethyl)aniline 535-52-4
Price
US $120.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000000
Release date
2024-08-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Fluoro-5-(trifluoromethyl)aniline 535-52-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

535-52-4, 2-Fluoro-5-(trifluoromethyl)anilineRelated Search:

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  • 535-52-4
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