ChemicalBook > CAS DataBase List > ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE

Product Name
ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
CAS No.
88150-75-8
Chemical Name
ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
Synonyms
Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate;Amlodipine Impurity S;Amlodipine EP Impurity S;Amlodipine IH Impurity C;Benzeneethanol,β-amino-5-methoxy-;Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate;4-(2-PhthaliMidoethoxy)acetoacetic Acid Ethyl Ester;Ethyl-4(2-phthalimido ethoxy)acetoacetate (AMB-Ester);Ethyl 4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate;Ethyl 4-[2-(1,3-Dioxo-2-isoindolinyl)ethoxy]-3-oxobutanoate
CBNumber
CB61236455
Molecular Formula
C16H17NO6
Formula Weight
319.31
MOL File
88150-75-8.mol
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ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Property

Boiling point:
479.7±30.0 °C(Predicted)
Density 
1.297±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
pka
9.83±0.46(Predicted)
form 
Oil
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
P384570
Product name
4-(2-Phthalimidoethoxy)acetoaceticAcidEthylEster
Packaging
250mg
Price
$500
Updated
2021/12/16
TRC
Product number
P384570
Product name
4-(2-Phthalimidoethoxy)acetoaceticAcidEthylEster
Packaging
1g
Price
$1000
Updated
2021/12/16
ChemScene
Product number
CS-0061613
Product name
Ethyl4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate
Packaging
100mg
Price
$85
Updated
2021/12/16
ChemScene
Product number
CS-0061613
Product name
Ethyl4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate
Packaging
250mg
Price
$136
Updated
2021/12/16
AK Scientific
Product number
4048AC
Product name
Ethyl4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate
Packaging
100mg
Price
$203
Updated
2021/12/16
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ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Chemical Properties,Usage,Production

Uses

4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester is an intermediate in the synthesis of Amlodipine Besilate (A633500) related compounds.

Synthesis

3891-07-4

638-07-3

88150-75-8

a. Add 2400 mL of tetrahydrofuran to reaction flask A. Cool the mixture to -10°C or lower. Add 750 g of N-hydroxyethylphthalimide and 345 g of NaH sequentially (keep stirring at low speed during addition). Dropwise addition of ethyl 4-chloroacetoacetate was initiated within 30 minutes after addition of N-hydroxyethylphthalimide and NaH. The temperature of the reaction flask was maintained below -10 °C and 732 g of ethyl 4-chloroacetoacetate was slowly added dropwise, controlling the temperature below 0 °C. The dropwise process lasted for 1.5 to 2 hours. The temperature was then raised to 28 to 32 °C and the reaction was carried out for 5 to 6 hours. Upon completion of the reaction, 1500 mL of toluene was added and the temperature was lowered to below 5°C to obtain a toluene dilution of the reaction solution. b. In reaction flask B, 1700 mL of toluene, 2800 mL of water, and 1178 g of acetic acid were added and the temperature was maintained below 5°C. The toluene dilution of the reaction solution obtained in step a was slowly added to the reaction flask B at a temperature below 10°C. The addition process lasted from 1 to 1.5 hours. After stirring for 10 minutes, the mixture was allowed to stand for 15 minutes to separate and remove the aqueous layer. The toluene layer was washed five times with brine (2500 mL each time) with a mass fraction of 4%. Anhydrous magnesium sulfate was added to the washed toluene solution for drying, followed by concentration of the toluene solution under reduced pressure to remove toluene (not less than 2700 mL of toluene was removed, and the toluene content did not exceed a predetermined value) to ultimately obtain ethyl-4-(2-phthalimidoethoxy)acetoacetate in 93% yield.

References

[1] Patent: CN106749187, 2017, A. Location in patent: Paragraph 0031; 0032; 0033; 0034
[2] Patent: WO2004/58711, 2004, A1. Location in patent: Page 18, 19
[3] Patent: WO2005/16885, 2005, A2. Location in patent: Page/Page column 47-49
[4] Patent: WO2005/25507, 2005, A2. Location in patent: Page/Page column 166-167
[5] Patent: WO2005/25507, 2005, A2. Location in patent: Page/Page column 166-167

ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE Suppliers

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View Lastest Price from ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE manufacturers

Career Henan Chemical Co
Product
ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE 88150-75-8
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-17

88150-75-8, ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATERelated Search:

Ethyl 4-bromomethyl-2-(2-pyridyl)thiazole-5-carboxylate, 97% ETHYL 3-CHLOROTETRAFLUOROPROPIONATE 4-(2-HYDROXYPROPYL)PIPERAZINE-1-CARBOXYLIC ACID ETHYL ESTER 3-Ethoxy-4-iodobenzoic acid ethyl ester 5-ALA Ethyl Ester Hydrochloride Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Loratadine N-Oxide Maleimide Ethyl-2-(diphenylaMino)pyriMidine-5-carboxylate ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE Isopropenylboronic acid pinacol ester

  • ETHYL-4-(2-(PHTHALIMIDO)ETHOXY)ACETOACET ATE (MEIS S.NO.1122 & COUNTRY GROUP B)
  • ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
  • Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate
  • Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate
  • 4-(2-PhthaliMidoethoxy)acetoacetic Acid Ethyl Ester
  • Butanoic acid,4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxo-, ethyl ester
  • Amlodipine IH Impurity C
  • Amlodipine Impurity S
  • Ethyl 4-[2-(1,3-Dioxo-2-isoindolinyl)ethoxy]-3-oxobutanoate
  • Ethyl 4-[2-(1,3-dioxoisoindol-2-yl)ethoxy]-3-oxobutanoate
  • ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-...
  • Ethyl-4(2-phthalido) ethoxy aceto acetateQ: What is Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What is the CAS Number of Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What is the storage condition of Ethyl-4(2-phthalido) ethoxy aceto acetate Q: What are the applications of Ethyl-4(2-phthalido) ethoxy aceto acetate
  • Ethyl-4(2-phthalimido ethoxy)acetoacetate (AMB-Ester)
  • Benzeneethanol,β-amino-5-methoxy-
  • Ethyl 4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoate
  • Amlodipine EP Impurity S
  • Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate (Amlodipine intermediate)
  • 88150-75-8