ChemicalBook > CAS DataBase List > Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride

Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride

Product Name
Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
CAS No.
101526-62-9
Chemical Name
Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
Synonyms
CK-1752;Ck 1752a;Sematilide HCl;Sematilide (CK-1752);Sematilide hydrochloride;Sematilide monohydrochloride;Sematilide monohydrochloride monohydrate;Sematilide monohydrate monohydrochloride;N-[2-(diethylamino)ethyl]-4-(methanesulfonamido)benzamide,hydrochloride;N-(2-(Diethylamino)ethyl)-4-((methylsulfonyl)amino)benzamide monohydrochloride
CBNumber
CB61245219
Molecular Formula
C14H23N3O3SHClH2O
Formula Weight
0
MOL File
101526-62-9.mol
More
Less

Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Property

Melting point:
141-142° (Lumma); mp 137° and mp 142° (Argentieri)
storage temp. 
2-8°C
solubility 
H2O: ≥16mg/mL
pka
pKa1 7.60; pKa2 9.51(at 25℃)
form 
powder
color 
white to beige
More
Less

Safety

WGK Germany 
3
Toxicity
LD50 i.p. in mice: 250-300 mg/kg (Lumma); LD50 in mice, rats, dogs (mg/kg): 96, 92, 143-175 i.v.; 1,800, 3,200, 500-1,000 orally (Argentieri)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S0323
Product name
Sematilide monohydrochloride monohydrate
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$620
Updated
2023/01/07
Sigma-Aldrich
Product number
S0323
Product name
Sematilide monohydrochloride monohydrate
Purity
≥99% (HPLC), white solid
Packaging
10mg
Price
$136
Updated
2022/05/15
Cayman Chemical
Product number
28272
Product name
Sematilide (hydrochloride)
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
28272
Product name
Sematilide (hydrochloride)
Packaging
50mg
Price
$469
Updated
2024/03/01
Cayman Chemical
Product number
28272
Product name
Sematilide (hydrochloride)
Packaging
5mg
Price
$68
Updated
2024/03/01
More
Less

Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Chemical Properties,Usage,Production

Uses

Cardiac depressant (anti-arrhythmic).

Uses

Sematilide, also known as CK-1752, is a class III antiarrhythmic. It is a selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.

Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Suppliers

China 18 Switzerland 1 United Kingdom 1 United States 9 Global 29

101526-62-9, Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochlorideRelated Search:

Semaglutide N-(DIETHYLAMINOETHYL)-4-METHYLSULFOAMINOBENZAMIDE Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride 4-(Methylsulfonylamino)benzylamine 4-(METHYLSULFONYLAMINO)BENZYLAMINEHYDROCHLORIDE

  • Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
  • CK-1752A, N-[2-(Diethylamino)ethyl]-4μ-[(methylsulfonyl)amino]benzamide monohydrate monohydrochloride
  • Sematilide monohydrate monohydrochloride
  • Ck 1752a
  • N-(2-(Diethylamino)ethyl)-4-((methylsulfonyl)amino)benzamide monohydrochloride
  • Sematilide HCl
  • Sematilide hydrochloride
  • Sematilide monohydrochloride
  • N-(2-(Diethylamino)ethyl)-4-((methylsulfonyl)amino)benzamide monohydrochloride monohydrate
  • Sematilide monohydrochloride monohydrate
  • CK-1752
  • Benzamide,N-[2-(diethylamino)ethyl]-4-[(methylsulfonyl)amino]-, hydrochloride (1:1)
  • Sematilide (CK-1752)
  • SEMATILIDE HYDROCHLORIDE; SEMATILIDE HCL; SEMATILIDE HYDROCHLORIDE; SEMATILIDE; CK-1752A; CK1752A; CK 1752A; CK-1752; CK1752; CK 1752.
  • N-[2-(diethylamino)ethyl]-4-(methanesulfonamido)benzamide,hydrochloride
  • CK 1752,Potassium Channel,antiarrhythmic,channel,blocker,Sematilide,Inhibitor,KcsA,inhibit,current,CK1752,Sematilide hydrochloride,IKr
  • 101526-62-9
  • C14H23N3O3SHClH2O