1-Boc-4-methylpiperazine

Product Name: 1-Boc-4-methylpiperazine
CAS No.: 53788-49-1
Chemical Name: 1-Boc-4-methylpiperazine
Synonyms: 1-BOC-4-METHYLPIPERAZINE;N-Boc-N-methylpiperazine;N-Boc-N-Methylpiperazine-d3;4-Methylpiperazine, N1-BOC protected;N-tert-Butoxycarbonyl-N-methylpiperazine;1-Methyl-4-(tert-butoxycarbonyl)piperazine;tert-butyl 4-methylpiperazine-1-carboxylate;4-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-Methylpiperazine-1-carboxylic Acid tert-Butyl Ester-d3;4-Methyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
CBNumber: CB6126665
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 53788-49-1.mol

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1-Boc-4-methylpiperazine Property

Boiling point:: 254.8±33.0 °C(Predicted)
Density: 1.023±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
pka: 6.90±0.10(Predicted)
form: Oil
color: Colorless

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B656970
Product name: N-Boc-N-methylpiperazine
Packaging: 2g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB66832
Product name: 1-BOC-4-methylpiperazine
Packaging: 5G
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0014692
Product name: N-BOC-N-METHYLPIPERAZINE
Purity: 95.00%
Packaging: 50MG
Price: $739.2
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 7632
Product name: N-Boc-N-methylpiperazine
Packaging: 50mg
Price: $890
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0014692
Product name: N-BOC-N-METHYLPIPERAZINE
Purity: 95.00%
Packaging: 500MG
Price: $1871.1
Updated: 2021/12/16

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1-Boc-4-methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

Colorless Oil

Uses

1-Boc-4-methylpiperazine can be used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.

Synthesis

109-01-3

24424-99-5

53788-49-1

Di-tert-butyl dicarbonate (3.48 mL, 15.0 mmol) was slowly added to a solution of N-methylpiperazine (1.00 g, 10.0 mmol) in tetrahydrofuran (10 mL) under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solution was concentrated and the product was purified by silica gel column chromatography. The grades containing 1-boc-4-methylpiperazine were collected, concentrated and dried under reduced pressure to afford the target compound 1-boc-4-methylpiperazine (2.15 g, quantitative yield). The structure of the product was confirmed by 1H-NMR (CDCl3), δ: 3.44 (4H, t, J = 5.0 Hz), 2.34 (4H, t, J = 5.0 Hz), 2.29 (3H, s), 1.46 (9H, s).

References

[1] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[2] Patent: EP2703406, 2014, A1. Location in patent: Paragraph 0392
[3] Asian Journal of Chemistry, 2017, vol. 29, # 6, p. 1313 - 1316
[4] Tetrahedron Letters, 2009, vol. 50, # 46, p. 6244 - 6246
[5] Journal of Organic Chemistry, 2006, vol. 71, # 21, p. 8283 - 8286

1-Boc-4-methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-4-methylpiperazine Suppliers

Canada 2 China 57 Germany 2 India 2 United Kingdom 4 United States 12 Global 79

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53788-49-1, 1-Boc-4-methylpiperazineRelated Search:

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4-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-Methyl-4-(tert-butoxycarbonyl)piperazine

4-Methyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester

N-Boc-N-methylpiperazine

1-BOC-4-METHYLPIPERAZINE

4-Methyl-1-piperazinecarboxylic Acid 1,1-DiMethylethyl Ester-d3

4-Methylpiperazine-1-carboxylic Acid tert-Butyl Ester-d3

N-Boc-N-Methylpiperazine-d3

4-Methylpiperazine, N1-BOC protected

tert-Butyl 4-methylpiperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-methylpiperazine

tert-butyl 4-methylpiperazine-1-carboxylate

N-tert-Butoxycarbonyl-N-methylpiperazine

1-Piperazinecarboxylic acid, 4-methyl-, 1,1-dimethylethyl ester

53788-49-1

Intermediates

Piperidines, Piperidones, Piperazines

Heterocyclic Compounds

Heterocycles