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ADRENORPHIN

Product Name
ADRENORPHIN
CAS No.
88866-92-6
Chemical Name
ADRENORPHIN
Synonyms
Metorphacid;ADRENORPHIN;METORPHAMIDE;METORPHINAMIDE;ADRENORPHIN (FREE ACID);METORPHAMIDE (FREE ACID);Adrenorphin, ≥95% (HPLC);Tyr-Gly-Gly-Phe-Arg-Arg-Val;8-L-Valineadrenorphin (human);TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL
CBNumber
CB6129590
Molecular Formula
C44H68N14O10S
Formula Weight
985.16
MOL File
88866-92-6.mol
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ADRENORPHIN Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
≥27.75 mg/mL in H2O with ultrasonic; ≥5.64 mg/mL in EtOH with ultrasonic; ≥98.5 mg/mL in DMSO
form 
solid
pka
3.34±0.10(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T8156
Product name
Adrenorphin
Purity
≥95% (HPLC)
Packaging
1mg
Price
$163
Updated
2022/05/15
Alfa Aesar
Product number
J66389
Product name
Adrenorphin, free acid
Packaging
5mg
Price
$169
Updated
2021/12/16
Usbiological
Product number
A0909-41
Product name
Adrenorphin
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
A0909-41A
Product name
Adrenorphin, free acid
Packaging
1mg
Price
$531
Updated
2021/12/16
Biorbyt Ltd
Product number
orb364179
Product name
Adrenorphin (Free acid)
Purity
> 95%
Packaging
5mg
Price
$552.5
Updated
2021/12/16
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ADRENORPHIN Chemical Properties,Usage,Production

Uses

Metorphacid Trifluoroacetate Salt is amino acid sequence; protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components.

Biological Activity

adrenorphin, also sometimes referred to as metorphamide, is an endogenous, c-terminally amidated, opioid octapeptide that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain(1). it was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors(2). it possesses analgesic and respiratory deppresive properties(3).figure 1 proteolytic cleavage of proenkephalin a

References

1. Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour". Nature 305 (5936): 721–3.2. Weber E, Esch FS, Böhlen P et al. (December 1983). "Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain". Proceedings of the National Academy of Sciences of the United States of America 80 (23): 7362–6.3. Xu SF, Lu WX, Zhou KR et al. (April 1985). "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits". Neuropeptides 6 (2): 121–31.

ADRENORPHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ADRENORPHIN manufacturers

Career Henan Chemical Co
Product
ADRENORPHIN 88866-92-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18
Career Henan Chemical Co
Product
ADRENORPHIN 88866-92-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

88866-92-6, ADRENORPHINRelated Search:


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  • H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-OH
  • ADRENORPHIN (FREE ACID)
  • ADRENORPHIN
  • TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL
  • Adrenorphin, ≥95% (HPLC)
  • 8-L-Valineadrenorphin (human)
  • Metorphacid
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