ADRENORPHIN

ChemicalBook > CAS DataBase List > ADRENORPHIN

Product Name: ADRENORPHIN
CAS No.: 88866-92-6
Chemical Name: ADRENORPHIN
Synonyms: Metorphacid;ADRENORPHIN;METORPHAMIDE;METORPHINAMIDE;ADRENORPHIN (FREE ACID);METORPHAMIDE (FREE ACID);Adrenorphin, ≥95% (HPLC);Tyr-Gly-Gly-Phe-Arg-Arg-Val;8-L-Valineadrenorphin (human);TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL
CBNumber: CB6129590
Molecular Formula: C44H68N14O10S
Formula Weight: 985.16
MOL File: 88866-92-6.mol

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ADRENORPHIN Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: ≥27.75 mg/mL in H2O with ultrasonic; ≥5.64 mg/mL in EtOH with ultrasonic; ≥98.5 mg/mL in DMSO
form: solid
pka: 3.34±0.10(Predicted)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T8156
Product name: Adrenorphin
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $163
Updated: 2022/05/15

Alfa Aesar

Product number: J66389
Product name: Adrenorphin, free acid
Packaging: 5mg
Price: $169
Updated: 2021/12/16

Usbiological

Product number: A0909-41
Product name: Adrenorphin
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Usbiological

Product number: A0909-41A
Product name: Adrenorphin, free acid
Packaging: 1mg
Price: $531
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364179
Product name: Adrenorphin (Free acid)
Purity: > 95%
Packaging: 5mg
Price: $552.5
Updated: 2021/12/16

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ADRENORPHIN Chemical Properties,Usage,Production

Uses

Metorphacid Trifluoroacetate Salt is amino acid sequence; protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components.

Biological Activity

adrenorphin, also sometimes referred to as metorphamide, is an endogenous, c-terminally amidated, opioid octapeptide that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain(1). it was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors(2). it possesses analgesic and respiratory deppresive properties(3).figure 1 proteolytic cleavage of proenkephalin a

References

1. Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour". Nature 305 (5936): 721–3.2. Weber E, Esch FS, Böhlen P et al. (December 1983). "Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain". Proceedings of the National Academy of Sciences of the United States of America 80 (23): 7362–6.3. Xu SF, Lu WX, Zhou KR et al. (April 1985). "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits". Neuropeptides 6 (2): 121–31.

ADRENORPHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ADRENORPHIN manufacturers

Career Henan Chemical Co

Product: ADRENORPHIN 88866-92-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

Career Henan Chemical Co

Product: ADRENORPHIN 88866-92-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

88866-92-6, ADRENORPHINRelated Search:

(MET(O)5)-ENKEPHALIN [LEU5]-ENKEPHALIN MET-ENKEPHALIN-ARG-PHE H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-OH MERGL LEU-ENKEPHALIN-ARG MET-ENKEPHALIN-ARG-ARG H-TYR-LYS-GLY-ARG-CYCLO(-GLU-TYR-ILE-LYS)-LEU-ILE-THR-ARG-PRO-ARG-TYR-NH2 ADRENORPHIN DES-TYR1-METHIONINE ENKEPHALINAMIDE ACETATE SALT H-ARG-VAL-OH ACETATE SALT METHIONINE ENKEPHALINAMIDE ACETATE SALT ADRENORPHIN Met-enkephalinamide Glycyl-glycyl-L-valine

METORPHAMIDE (FREE ACID)

METORPHINAMIDE

METORPHAMIDE

H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-OH

ADRENORPHIN (FREE ACID)

ADRENORPHIN

TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL

Adrenorphin, ≥95% (HPLC)

8-L-Valineadrenorphin (human)

Metorphacid

Tyr-Gly-Gly-Phe-Arg-Arg-Val

Metorphamide (free acid) H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-OH

L-Valine, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-

88866-92-6

C44H68N14O10S

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