ADRENORPHIN
- Product Name
- ADRENORPHIN
- CAS No.
- 88866-92-6
- Chemical Name
- ADRENORPHIN
- Synonyms
- Metorphacid;ADRENORPHIN;METORPHAMIDE;METORPHINAMIDE;ADRENORPHIN (FREE ACID);METORPHAMIDE (FREE ACID);Adrenorphin, ≥95% (HPLC);Tyr-Gly-Gly-Phe-Arg-Arg-Val;8-L-Valineadrenorphin (human);TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL
- CBNumber
- CB6129590
- Molecular Formula
- C44H68N14O10S
- Formula Weight
- 985.16
- MOL File
- 88866-92-6.mol
ADRENORPHIN Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ≥27.75 mg/mL in H2O with ultrasonic; ≥5.64 mg/mL in EtOH with ultrasonic; ≥98.5 mg/mL in DMSO
- form
- solid
- pka
- 3.34±0.10(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- T8156
- Product name
- Adrenorphin
- Purity
- ≥95% (HPLC)
- Packaging
- 1mg
- Price
- $163
- Updated
- 2022/05/15
- Product number
- J66389
- Product name
- Adrenorphin, free acid
- Packaging
- 5mg
- Price
- $169
- Updated
- 2021/12/16
- Product number
- A0909-41
- Product name
- Adrenorphin
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- A0909-41A
- Product name
- Adrenorphin, free acid
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- orb364179
- Product name
- Adrenorphin (Free acid)
- Purity
- > 95%
- Packaging
- 5mg
- Price
- $552.5
- Updated
- 2021/12/16
ADRENORPHIN Chemical Properties,Usage,Production
Uses
Metorphacid Trifluoroacetate Salt is amino acid sequence; protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components.
Biological Activity
adrenorphin, also sometimes referred to as metorphamide, is an endogenous, c-terminally amidated, opioid octapeptide that is produced from proteolytic cleavage of proenkephalin a and is widely distributed throughout the mammalian brain(1). it was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors(2). it possesses analgesic and respiratory deppresive properties(3).figure 1 proteolytic cleavage of proenkephalin a
References
1. Matsuo H, Miyata A, Mizuno K (1983). "Novel C-terminally amidated opioid peptide in human phaeochromocytoma tumour". Nature 305 (5936): 721–3.2. Weber E, Esch FS, Böhlen P et al. (December 1983). "Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain". Proceedings of the National Academy of Sciences of the United States of America 80 (23): 7362–6.3. Xu SF, Lu WX, Zhou KR et al. (April 1985). "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits". Neuropeptides 6 (2): 121–31.
ADRENORPHIN Preparation Products And Raw materials
Raw materials
Preparation Products
ADRENORPHIN Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from ADRENORPHIN manufacturers
- Product
- ADRENORPHIN 88866-92-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18
- Product
- ADRENORPHIN 88866-92-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18