moronic acid
- Product Name
- moronic acid
- CAS No.
- 6713-27-5
- Chemical Name
- moronic acid
- Synonyms
- moronicaci;moronic acid;3-Oxooleana-18-ene-28-oic acid;Olean-18-en-28-oic acid,3-oxo-;3-Oxo-5α-olean-18-en-28-oic acid
- CBNumber
- CB61322332
- Molecular Formula
- C30H46O3
- Formula Weight
- 454.68
- MOL File
- 6713-27-5.mol
moronic acid Property
- Melting point:
- 212 °C(dec.)
- Boiling point:
- 550.0±50.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- solubility
- Chloroform: Sparingly soluble: 1-10 mg/ml
Methanol: Slightly soluble: 0.1-1 mg/ml - form
- Solid
- pka
- 4.59±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- M2610
- Product name
- Moronic Acid
- Packaging
- 5MG
- Price
- $194
- Updated
- 2025/07/31
- Product number
- M2610
- Product name
- Moronic Acid
- Packaging
- 25MG
- Price
- $584
- Updated
- 2025/07/31
- Product number
- M651700
- Product name
- Moronic Acid
- Packaging
- 5mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- 38065
- Product name
- Moronicacid,≥96%(HPLC)
- Purity
- ≥96%(HPLC)
- Packaging
- 5MG
- Price
- $196.85
- Updated
- 2021/12/16
- Product number
- 38065
- Product name
- Moronicacid,96%(HPLC)
- Purity
- 96%(HPLC)
- Packaging
- 25MG
- Price
- $645.12
- Updated
- 2021/12/16
moronic acid Chemical Properties,Usage,Production
Chemical Properties
White crystalline needles; m. p. 210±2128C; [a]D 25: + 298 (c 0.41, CHCl3); IR (CHCl3): nmax = 3514 to 2800 (COOH), 1731 (COOH), 1695 (CO), 1457 cm-1 (C = C). EI :m/z (rel. int.) = 454 [M+, C30H46O3] (13), 410 (53), 408 (9), 248 (33), 235 (87), 191 (97), 189 (95), 163 (30), 119 (35), 95 (39), 69 (30). 1H-NMR (CDCl3, 300 MHz): d = 12.00 ± 10.00 (1H, COOH), 5.16 (1H, s, H-19), 2.47 (2H, m, H-2), 2.27 ± 2.04 (m), 1.98 (2H, m, H-1), 1.70 ± 1.20 (CH and CH2), 1.08, 1.03, 1.02, 1.00, 0.97, 0.94, 0.79 (21H, 7 s, 7CH3). 13C-NMR (CDCl3, 75 MHz, multiplicities by the DEPT pulse sequences): d = 218.2 (s, C-3), 182.3 (s, C-28), 136.5 (s, C-18), 133.2 (d, C-19), 54.8 (d, C-5), 50.4 (d, C-9), 47.9 (s, C-17), 47.2 (s, C-4), 42.5 (s, C-14), 41.4 (d, C-13), 40.5 (s, C-8), 39.8 (t, C-1), 36.9 (s, C-10), 34.0 (t, C-7), 33.8 (t, C-2), 33.5 (t, C-22), 33.4 (t, C-21), 33.3 (t, C-16), 32.0 (s, C-20), 30.3 (q, C-29), 29.3 (t, C-15), 29.0 (q, C-30), 26.8 (q, C-24), 26.0 (t, C-12), 21.4 (t, C-11), 20.9 (q, C-23), 19.6 (t, C6), 16.4 (q, C-26), 15.8 (q, C-25), 14.8 (q, C-27).
Uses
Moronic Acid and its derivatives can have antidiabetic activity by inhibiting PTP-1B. Moronic Acid is also shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization in rat models.
Definition
ChEBI: Moronic acid is a pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group. It has a role as a metabolite, an anti-HSV-1 agent and an anti-HIV agent. It derives from a hydride of an oleanane.
General Description
Moronic acid is a fatty acid found in the seeds of Morus alba. It has been shown to have anti-infective properties by binding to the bacterial efflux protein, which is responsible for transporting toxic compounds out of the cell. The binding of moronic acid to the efflux protein prevents it from functioning and leads to increased expression of proinflammatory genes, ultimately leading to cell death. Moronic acid has also been shown to bind to a receptor on Staphylococcus aureus that is responsible for regulating virulence factors, leading to decreased production of proteins such as coagulase and proteases. Moronic acid also binds with oleanolic acid and inhibits the growth of Mycobacterium tuberculosis in vitro.
in vivo
Moronic Acid (5-10 mg/kg, i.g., once daily, 20 days) regulates the ROS - NF - κB - NLRP3 signaling pathway in mice by inhibiting ROS, improving inflammatory bowel disease[2].
Moronic Acid extends the survival time of HSV-1 infected mice and slows the progression of skin lesions[3].
| Animal Model: | Mice induced by DSS[2] |
| Dosage: | 5, 10 mg/kg; daily; 20 days |
| Administration: | i.g. |
| Result: | Inhibited intestinal macrophage M1 polarization, inhibited the expression of inflammatory factors, and reduced ROS-NF-κB-NLRP3 signaling levels. |
IC 50
NLRP3
References
[1] MKHUSELI KOKI. Phytochemical Investigation and Biological Studies on Selected Searsia Species.[J]. Plants-Basel, 2022. DOI: 10.3390/plants11202793
[2] JUNKO ITO. Anti-AIDS Agents. 48. 1 Anti-HIV Activity of Moronic Acid Derivatives and the New Melliferone-Related Triterpenoid Isolated from Brazilian Propolis[J]. Journal of Natural Products , 2001, 64 10: 1278-1281. DOI: 10.1021/np010211x
[3] SHUILIANG RUAN Li Z. Moronic acid improves intestinal inflammation in mice with chronic colitis by inhibiting intestinal macrophage polarization[J]. Journal of Biochemical and Molecular Toxicology, 2022, 36 11. DOI: 10.1002/jbt.23188
[4] K. YASUKAWA. Inhibitory Effects of Brazilian Propolis on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis[J]. Journal of Pharmacy and Nutrition Sciences, 2012, 24 1. DOI: 10.6000/1927-5951.2012.02.01.10
[5] MARÍA RIOS1. Cytotoxic Activity of Moronic Acid and Identification of the New Triterpene 3,4-seco-Olean-18-ene-3,28-dioic Acid from Phoradendron reichenbachianum[J]. Planta medica, 2001, 101 1: 443-446. DOI:10.1055/s-2001-15823.
moronic acid Preparation Products And Raw materials
Raw materials
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