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DEBRISOQUIN SULFATE

Product Name
DEBRISOQUIN SULFATE
CAS No.
581-88-4
Chemical Name
DEBRISOQUIN SULFATE
Synonyms
Tendor;declinax;RO 5-3307;RO 5-33071;Debrisoquina;Debrisochinum;ebrisoquinsulfate;DEBRISOQUIN SULFATE;DEBRISOQUINE SULFATE;isocaramidinesulfate
CBNumber
CB6133940
Molecular Formula
C20H28N6O4S
Formula Weight
448.54
MOL File
581-88-4.mol
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DEBRISOQUIN SULFATE Property

Melting point:
278-280°, 284-285° or 266-268° (H2O)
storage temp. 
room temp
solubility 
H2O: 20 mg/mL with heat
form 
Solid
color 
Pale Yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
NW7010000
Toxicity
LD50 in neonate, adult rats (mg/kg): 88 ±18, 1580 ±163 orally (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1306
Product name
Debrisoquine sulfate
Packaging
100mg
Price
$280
Updated
2024/03/01
Sigma-Aldrich
Product number
BP103
Product name
Debrisoquine sulfate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$266
Updated
2024/03/01
Cayman Chemical
Product number
29568
Product name
Debrisoquin (hemisulfate)
Packaging
10mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
29568
Product name
Debrisoquin (hemisulfate)
Packaging
250mg
Price
$595
Updated
2024/03/01
Cayman Chemical
Product number
29568
Product name
Debrisoquin (hemisulfate)
Packaging
50mg
Price
$155
Updated
2024/03/01
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DEBRISOQUIN SULFATE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Declinax,Roche,UK,1967

Uses

Antihypertensive.

Manufacturing Process

27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The resulting mixture was kept at room temperature with occasional shaking. After a short period of time, methylmercaptan began to escape, and the mixture warmed up slightly. After then standing for 24 hours, crystals formed. They were filtered off and rinsed with ice cold water. Recrystallization from approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2- carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
Another batch prepared in the same manner melted at 284°C to 285°C due to a minute difference in moisture content.
Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.

brand name

Declinax (HoffmannLaRoche).

Therapeutic Function

Antihypertensive

Biochem/physiol Actions

Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.

DEBRISOQUIN SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DEBRISOQUIN SULFATE Suppliers

Canada 1 China 20 Germany 1 Switzerland 1 United Kingdom 2 United States 9 Global 34
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Carbosynth Limited
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6581
Advantage
61

581-88-4, DEBRISOQUIN SULFATERelated Search:

FERROUS SULFATE DEBRISOQUIN SULFATE--N/H BENZYLGUANIDINE SULFATE (2:1) debrisoquine 1,1-DIMETHYLGUANIDINE SULFATE CHEMBRDG-BB 4015994 rac 4-Hydroxydebrisoquine Hemisulfate DEBRISOQUIN SULFATE 1,1-DIETHYLGUANIDINE SULFATE N'-BENZYLGUANIDINEACETATE 1-METHYLGUANIDINE SULFATE N-ETHYLGUANIDINIUM SULFATE

  • 3,4-dihydro-2(1h)-isoquinolinecarboximidamidsulfate(2:1)
  • 3,4-dihydro-2(1h)-isoquinolinecarboxamidinsulfate(2:1)
  • 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, Debrisoquin sulfate, Ro5-33071
  • Tendor
  • 3,4-Dihydro-2(1H)-isoquinolinecarboxamide hemisulfate
  • 3,4-DIHYDRO-2(1H)-ISOQUINOLINECARBOXAMIDINE 0.5 H2SO4
  • 3,4-DIHYDRO-2-[1H]-ISOQUINOLINECARBOXAMIDINE SULFATE SALT
  • DEBRISOQUINE SULFATE
  • DEBRISOQUIN SULFATE
  • bis(2-amidino-1,2,3,4-tetrahydroisoquinoline) sulphate
  • declinax
  • isocaramidinesulfate
  • RO 5-3307
  • RO 5-33071
  • 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
  • DEBRISOQUINEHEMISULPHATE
  • 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide Hemisulfate
  • Debrisoquin Hemisulfate
  • Debrisoquine Hemisulfate
  • Isocaramidine Hemisulfate
  • 3,4-dihydro-2(1h)-isoquinolinecarboxamidinesulfate
  • ebrisoquinsulfate
  • Debrisochinum
  • Debrisoquina
  • 581-88-4
  • C10H13N32H2SO4
  • C20H26N6H2SO4
  • 2C10H13N3H2O4S
  • C10H13N312H2SO4
  • Its metabolite may induce Parkinsonism.
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • L to O
  • Monoamine oxidase competitive inhibitor
  • Biochemicals and Reagents
  • BioChemical
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides and Nucleosides
  • Nucleotides
  • Pharmaceuticals