Artificial flavor Chemical properties Content analysis Toxicity Usage limit Standard for Maximum Allowable Amount Chemical properties Application Preparation Category Toxic classification Acute toxicity Flammability and Hazardous characteristics Storage and transportation characteristics Extinguishing agent
ChemicalBook > CAS DataBase List > Carvacrol

Carvacrol

Artificial flavor Chemical properties Content analysis Toxicity Usage limit Standard for Maximum Allowable Amount Chemical properties Application Preparation Category Toxic classification Acute toxicity Flammability and Hazardous characteristics Storage and transportation characteristics Extinguishing agent
Product Name
Carvacrol
CAS No.
499-75-2
Chemical Name
Carvacrol
Synonyms
o-Thymol;5-ISOPROPYL-2-METHYLPHENOL;ISOTHYMOL;Cymenol;2-p-Cymenol;2-hydroxy-p-cymen;5-ISOPROPYL-O-CRESOL;2-METHYL-5-ISOPROPYLPHENOL;Phenol,2-methyl-5-(1-methylethyl)-;1-Hydroxy-2-methyl-5-isopropylbenzene
CBNumber
CB6134604
Molecular Formula
C10H14O
Formula Weight
150.22
MOL File
499-75-2.mol
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Carvacrol Property

Melting point:
3-4 °C(lit.)
Boiling point:
236-237 °C(lit.)
Density 
0.976 g/mL at 20 °C(lit.)
vapor pressure 
3.09-6.664Pa at 25℃
refractive index 
n20/D 1.522(lit.)
FEMA 
2245 | CARVACROL
Flash point:
224 °F
storage temp. 
-20°C
solubility 
1.25g/l
pka
10.38±0.10(Predicted)
form 
Liquid
color 
Colorless to Light orange to Yellow
Odor
Penetrating, dry-medicinal (“-phenolic”) - herbaceous odor with a spicy undertone.
Odor Type
spicy
Water Solubility 
Insoluble
JECFA Number
710
Merck 
14,1872
BRN 
1860514
Stability:
Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.
InChIKey
RECUKUPTGUEGMW-UHFFFAOYSA-N
LogP
3.33-3.49
CAS DataBase Reference
499-75-2(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-methyl-5-(1-methylethyl)-(499-75-2)
EPA Substance Registry System
Isopropyl-o-cresol (499-75-2)
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Safety

Hazard Codes 
C
Risk Statements 
22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 3
WGK Germany 
3
RTECS 
FI1225000
HazardClass 
8
PackingGroup 
III
HS Code 
29071990
Hazardous Substances Data
499-75-2(Hazardous Substances Data)
Toxicity
LD orally in rabbits: 100 mg/kg (Kochmann)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W224511
Product name
Carvacrol
Purity
natural, 99%, FG
Packaging
100g
Price
$71.3
Updated
2024/03/01
Sigma-Aldrich
Product number
W224511
Product name
Carvacrol
Purity
natural, 99%, FG
Packaging
1kg
Price
$418
Updated
2024/03/01
Sigma-Aldrich
Product number
W224511
Product name
Carvacrol
Purity
natural, 99%, FG
Packaging
10Kg
Price
$2250
Updated
2024/03/01
Sigma-Aldrich
Product number
W224502
Product name
Carvacrol
Purity
≥98%, FCC, FG
Packaging
100g
Price
$76.5
Updated
2024/03/01
Sigma-Aldrich
Product number
W224502
Product name
Carvacrol
Purity
≥98%, FCC, FG
Packaging
1kg
Price
$150
Updated
2024/03/01
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Carvacrol Chemical Properties,Usage,Production

Artificial flavor

Carvacrol is the isomeric body of thymol with similar aroma as thymol. Carvacrol naturally exists in thyme oil and other essential oils, having especially high content in the thyme oil produced in Spain.
Carvacrol is mainly used in the preparation of dill, girofle, mint and vanilla flavor to be used for toothpaste, toothpaste powder, oral products, talcum powder, soap and daily industrial products. In medicine, it is used for local anesthetics. In addition, carvacrol is capable of killing bacteria and intestinal parasites and can be used as disinfectants and fungicides. According to the information reported, the acute toxicity data of carvacrol: oral LD50810mg/kg (rat), skin test: LD50> 5g/kg (rabbit).
Thyme plant has its origin including the Northeast, Hebei, and Inner Mongolia, Gansu, Qinghai and Xinjiang and other provinces. Ingredients: whole plant of thyme contains about 0.15~0.5% volatile oil (in oil, the component mainly contains carvacrol, paraffin, thymol), amaroid and tannin. Leaves contain free oleanolic acid, ursolic acid, caffeic acid and so on. Thyme can be not only used in medicine, for spices, but also be as the superior natural health ingredients of the processed foods. Since the 1980s, thyme-like herbal foods have become very popular. Studies have shown that thyme-containing volatile oils, in addition to being used as seasoning and for treatment of illnesses, also have anti-corrosion, antibacterial and other functions. Therefore, the consumers can benefit a lot using it as food raw materials. Because of this, in Europe, natural herbal tea also contains thyme. For example, a kind of herb tea raw material having anti-cough effect and being able to prevent and treat bronchitis has 10% thyme leaves.

Image 1: Thymus plant

Chemical properties

Use sulfuric acid to sulfonate the p-isopropyl toluene, generating p-isopropyl toluene-2-sulfonic acid. Then we can obtain carvacrol after alkali melting treatment.

Image 2: Preparation of carvacrol from p-isopropyltoluene
Carvacrol, when co-melted together with potassium hydroxide, can give 2-hydroxy-4-isopropyl benzoic acid while reaction with phosphorus pentachloride can generate 2-chloro-1-methyl-4-isopropyl benzene. In acetic acid, it reaction with 1 mol Bromine can generate 4-bromocarbinol while its reaction with 2 mol bromine can generate 4, 6-dibromo carvacrol; if reacted with bromine and aluminum, we can obtain tetrabromo-o-cresol. It is easily soluble in concentrated sulfuric acid to produce 2-methyl-5-isopropyl phenol-4-sulfonic acid. In aqueous sodium hydroxide solution, it can be reacted with formaldehyde to generate carvacrol phenols alcohol:

Image 3: The reaction between carvacrol and formaldehyde for generation of carvacrol phenolic alcohol
It exhibits green color when reacted with ferric chloride in ethanol with no significant color in the water.

Content analysis

It can be determined by the non-polar column method by GT-10-4.

Toxicity

LD orally in rabbits: 100 mg/kg (Kochmann)

Usage limit

FEMA (mg/kg): soft drinks 26; cold drinks 34; candy 92; baked goods 120; condiments 37.
Take appropriate as limit (FDA § 172.515, 2000).
Allow to use (GB 2760-1996).

Standard for Maximum Allowable Amount

Name of additive
Field allowed to use it as additive
Function of additive
Maximal allowable amount(g/kg)
arvacrol
Food
Food spices
The perfume ingredients used in formulating fragrances shall not exceed the maximum allowable documented amount in GB 2760

Chemical properties

It appears as colorless to pale yellow slightly viscous oil. When placed in air and light, its color becomes darker. It has spicy, cool incense, herbs incense with thymol-like smell. It has a boiling point of 238 ° C, the melting point of 0.5 to 1 ° C and the flash point of 100 ° C. It is soluble ethanol, ethyl ether, propylene glycol and alkali, do not dissolve in water. It is miscible in oil.
The natural products are found in thyme oil (about 70%), oregano oil (about 80%) and mange to oil and so on.

Application

Spices; It is mainly used for the preparation of dill, girofle, meat, peppermint, vanilla flavor and so on.
It can be used for the preparation of spices, fungicides and disinfectants. As a spice, it can be used in toothpaste, soap and other daily necessities, but also for food flavors.
It can be used for spices, food additives, feed additives, antioxidants, sanitation fungicide, insect repellent, preservatives, deodorant and pharmaceutical intermediates.

Preparation

It can be obtained through treatment of the essential oil containing rich content of natural carvacrol followed by ether extraction or steam distillation to derive it.
It can be derived by the sulfonation of thymol followed by alkali treatment.

Category

Pesticides

Toxic classification

middle-level poisoning

Acute toxicity

Oral-rat LD50: 810 mg/kg; intravenous-mouse LD50: 80 mg/kg
Stimulation Data Skin-Rabbit 500 mg/24 h Severe

Flammability and Hazardous characteristics

It is flammable upon heat, fire and strong oxidants with thermal decomposition releasing spicy stimulated smoke

Storage and transportation characteristics

Treasury: low temperature, ventilated and dry; avoid fire and high temperature; store it separately from oxidant.

Extinguishing agent

fog, carbon dioxide, foam, dry powder

Chemical Properties

liquid

Chemical Properties

Carvacrol has a characteristic pungent, warm odor. The commercial product consists of a mixture of isomers differing because of the position of the isopropyl radical. The odor characteristics differ between the technical (lower grade) and pure (higher grade) commercial products.

Occurrence

Reported found in cumin seed, thyme, oregano, calamus, lovage, myrtle and lemon balm.

Uses

Reference Standard in the analysis of herbal medicinal products

Uses

Carvacrol is a flavoring agent that is a colorless to pale yellow liquid. it has a spicy and pungent odor, resembling thymol. it is insoluble in water and soluble in alcohol and ether. it is a mixture of the isomeric carvacrols (isopropyl o-creols), and is obtained by chemical synthesis. it is also an ingredient of savory, a fragrant herb in nature.

Uses

As disinfectant; in organic syntheses.

Definition

ChEBI: A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).

Preparation

From p-cymene by sulfonation and subsequent alkali fusion.

Aroma threshold values

Detection at 2.29 ppm.

Taste threshold values

Taste characteristics at 5.0 ppm: spicy, herbal phenolic, medicinal and woody.

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 2545, 1978 DOI: 10.1016/S0040-4039(01)94822-1

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Moderately toxic by skin contact. A severe skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Carvacrol Preparation Products And Raw materials

Raw materials

Preparation Products

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Carvacrol Suppliers

Jiangxi Zhonghuan New Material Co., Ltd.
Tel
0796-8107286 13766287383
Email
2246992030@qq.com
Country
China
ProdList
162
Advantage
58
Inspire-Biotech Co., Ltd.
Tel
0792-; 18070228777
Fax
-
Email
Eric@inspire-biotech.cn
Country
China
ProdList
24
Advantage
58
Ji`an Borui Spice Oil Co., Ltd.
Tel
0796-0796-8181760 13361763840
Fax
0796-8186433
Email
3142054383@qq.com
Country
China
ProdList
25
Advantage
58
Taian Jiayue Bio-chemical Co. LTD
Tel
15318151873
Email
285424065@qq.com
Country
China
ProdList
4548
Advantage
58
Jiangxi Planty Manor Health Industry Co., Ltd.
Tel
0796-18507969315 18507969315
Email
3686433662@qq.com
Country
China
ProdList
268
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
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View Lastest Price from Carvacrol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Carvacrol 499-75-2
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-30
Hebei Weibang Biotechnology Co., Ltd
Product
Carvacrol 499-75-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Carvacrol; Thyme extract 499-75-2
Price
US $0.00/KG
Min. Order
1KG
Purity
90%; 99% HPLC
Supply Ability
1000KG
Release date
2022-09-27

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