PHALLACIDIN

Product Name: PHALLACIDIN
CAS No.: 26645-35-2
Chemical Name: PHALLACIDIN
Synonyms: PHALLICIDIN;PHALLACIDIN;Phallacidin DISCONTINUED;CYCLO(ALA-2-MERCAPTO-TRP-4;phallacidin from amanita phalloides;Phallacidin from Amanita phalloides;Cyclo(Ala-2-Mercapto-Trp-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO);-3-hydroxy-d-alpha-aspartyl-l-cysteinyl-cis-4-hydroxy-l-prolyl)cyclic(2-6)-s;cyclic(l-alanyl-2-mercapto-l-tryptophyl-4,5-dihydroxy-l-leucyl-l-valyl-erythro
CBNumber: CB6136097
Molecular Formula: C37H50N8O13S
Formula Weight: 846.9
MOL File: 26645-35-2.mol

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PHALLACIDIN Property

Density: 1.1678 (rough estimate)
refractive index: 1.7400 (estimate)
solubility: DMF: Soluble; DMSO: Soluble; Methanol: Soluble; Water: Soluble
form: White to off-white powder.
color: White to off-white
Appearance: Solid Powder
biological source: Amanita phalloides
Sequence: Ala-Trp-Leu-Val-{D-Asp}-Cys-{Hyp} (Sulfide bridge: Trp2- Cys6)

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 22-36/37/39-45
RIDADR: 1544
WGK Germany: 3
RTECS: GT8943000
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8157
Product name: Phallacidin from Amanita phalloides
Purity: ≥85%
Packaging: 1mg
Price: $389
Updated: 2024/03/01

Cayman Chemical

Product number: 18146
Product name: Phallacidin
Purity: ≥90%
Packaging: 1mg
Price: $214
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: PEP0003782
Product name: PHALLACIDIN
Purity: 95.00%
Packaging: 1MG
Price: $354.9
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0003782
Product name: PHALLACIDIN
Purity: 95.00%
Packaging: 5MG
Price: $1062.38
Updated: 2021/12/16

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PHALLACIDIN Chemical Properties,Usage,Production

Description

Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds filamentous actin (F-actin) like phalloidin , but contains a carboxyl group for coupling reactions.

Uses

Toxin Phallacidin is a weak fluorescent bicyclic peptide probe in aquous solution, Which is isolated from Amanita phalloides mushroom and could be used for blocking F-actin staining by labeled phallotoxins, which promotes actin polymerization.

Uses

Phallacidin is a natural mycotoxin first isolated from the death cap mushroom. It binds filamentous actin like phalloidin.

Definition

ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.

Biochem/physiol Actions

Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.

Enzyme inhibitor

This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin

References

[1] L S BARAK. Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1980, 77 2: 980-984. DOI: 10.1073/pnas.77.2.980
[2] L S BARAK W W W R R Yocum. In vivo staining of cytoskeletal actin by autointernalization of nontoxic concentrations of nitrobenzoxadiazole-phallacidin.[J]. Journal of Cell Biology, 1981, 89 2: 368-372. DOI: 10.1083/jcb.89.2.368

PHALLACIDIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PHALLACIDIN Suppliers

China 41 Germany 2 India 1 Switzerland 2 United Kingdom 2 United States 8 Global 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
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Advantage: 65

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Email: info@efebio.com
Country: China
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Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
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Beijing Solarbio Science & Tecnology Co., Ltd.

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Shanghai Zhen Li Biological Technology Co., Ltd

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
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26645-35-2, PHALLACIDINRelated Search:

3-AMINO-PENTANOIC ACID PENTAETHYLENEHEXAMINE 5-Aminolevulinic acid (R)-Isoserine 1,4,7,10,13-Pentaazatridecane (S)-3-Hydroxypyrrolidine DL-Isoserine Dibutylurea 1-Methyl-3-pyrrolidinol AC-TRP-NH2 4-Methylthio-2-butanone (2S,3S)-3-AMINO-2-HYDROXYHEXANOIC ACID (S)-3-Aminopentanoic acid PYRROLIDINE-1-CARBOXYLIC ACID AMIDE (S)-(+)-1-Methyl-3-pyrrolidinol L-TRP-GLY AMIDE PHALLACIDIN 1-AMINO-4-HYDROXY-BUTAN-2-ONE

5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)

CYCLO(ALA-2-MERCAPTO-TRP-4

PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-2-MERCAPTO-TRP-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO)

5-Dihydroxy-Leu-Val-erythro-3-Hydroxy-<SC>D</SC>-Asp-Cys-cis-4-Hydroxy-Pro)

Cyclo(Ala-2-Mercapto-Trp-4

PHALLACIDIN FROM AMANITA PHALLOIDES;CYCLO(ALA-2-MERCAPTO-TRP-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-<SC>D</SC>-ASP-CYS-CIS-4-HYDROXY-PRO)

PHALLACIDIN

PHALLICIDIN

CYCLO[ALA-2-MERCAPTO-TRP-4,5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO]

-3-hydroxy-d-alpha-aspartyl-l-cysteinyl-cis-4-hydroxy-l-prolyl)cyclic(2-6)-s

cyclic(l-alanyl-2-mercapto-l-tryptophyl-4,5-dihydroxy-l-leucyl-l-valyl-erythro

phallacidin from amanita phalloides

Cyclo[L-Ala-L-Trp2(1)-4,5-dihydroxy-L-Leu-L-Val-[(3S)-3-hydroxy-D-Asp-]-L-Cys(1)-L-c4Hyp-]

Cyclo[L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl-L-valyl-(3S)-3-hydroxy-D-α-aspartyl-L-cysteinyl-(4S)-4-hydroxy-L-prolyl], cyclic (2→6)-thioether

Phallacidin DISCONTINUED

Phallacidin from Amanita phalloides

26645-35-2

C37H50N8O13S

Biochemicals and Reagents

BioChemical

Auxiliary Proteins

Other

Proteins and Derivatives

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