PHALLACIDIN
- Product Name
- PHALLACIDIN
- CAS No.
- 26645-35-2
- Chemical Name
- PHALLACIDIN
- Synonyms
- PHALLICIDIN;PHALLACIDIN;Phallacidin DISCONTINUED;CYCLO(ALA-2-MERCAPTO-TRP-4;phallacidin from amanita phalloides;Cyclo(Ala-2-Mercapto-Trp-4;5-DIHYDROXY-LEU-VAL-ERYTHRO-3-HYDROXY-D-ASP-CYS-CIS-4-HYDROXY-PRO);-3-hydroxy-d-alpha-aspartyl-l-cysteinyl-cis-4-hydroxy-l-prolyl)cyclic(2-6)-s;cyclic(l-alanyl-2-mercapto-l-tryptophyl-4,5-dihydroxy-l-leucyl-l-valyl-erythro;Cyclo[L-Ala-L-Trp2(1)-4,5-dihydroxy-L-Leu-L-Val-[(3S)-3-hydroxy-D-Asp-]-L-Cys(1)-L-c4Hyp-]
- CBNumber
- CB6136097
- Molecular Formula
- C37H50N8O13S
- Formula Weight
- 846.9
- MOL File
- 26645-35-2.mol
PHALLACIDIN Property
- Density
- 1.1678 (rough estimate)
- refractive index
- 1.7400 (estimate)
- solubility
- DMF: Soluble; DMSO: Soluble; Methanol: Soluble; Water: Soluble
- form
- White to off-white powder.
Safety
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 22-36/37/39-45
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- GT8943000
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- P8157
- Product name
- Phallacidin from Amanita phalloides
- Purity
- ≥85%
- Packaging
- 1mg
- Price
- $389
- Updated
- 2024/03/01
- Product number
- 18146
- Product name
- Phallacidin
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- PEP0003782
- Product name
- PHALLACIDIN
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $354.9
- Updated
- 2021/12/16
- Product number
- PEP0003782
- Product name
- PHALLACIDIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $1062.38
- Updated
- 2021/12/16
PHALLACIDIN Chemical Properties,Usage,Production
Description
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds filamentous actin (F-actin) like phalloidin , but contains a carboxyl group for coupling reactions.
Uses
Toxin Phallacidin is a weak fluorescent bicyclic peptide probe in aquous solution, Which is isolated from Amanita phalloides mushroom and could be used for blocking F-actin staining by labeled phallotoxins, which promotes actin polymerization.
Uses
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom. It binds filamentous actin like phalloidin.
Definition
ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.
Biochem/physiol Actions
Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.
Enzyme inhibitor
This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin