ChemicalBook > CAS DataBase List > 2,5-Dibromo-4-methylpyridine

2,5-Dibromo-4-methylpyridine

Uses

Product Name: 2,5-Dibromo-4-methylpyridine
CAS No.: 3430-26-0
Chemical Name: 2,5-Dibromo-4-methylpyridine
Synonyms: TIMTEC-BB SBB003142;2,5-Dibromo-4-methyL;2,5-DIBROMO-4-PICOLINE;3-Chloro-3-iodopyridine;2,5-Dibromo-4-picoline,98%;2,3-dibromo-4-methylpyridine;2,5-DIBROMO-4-METHYLPYRIDINE;Pyridine, 2,5-dibromo-4-methyl-;2,5-Dibromo-4-methylpyridine >2,5-Dibromo-4-methylpyridine, 97%
CBNumber: CB6140119
Molecular Formula: C6H5Br2N
Formula Weight: 250.92
MOL File: 3430-26-0.mol

Less

2,5-Dibromo-4-methylpyridine Property

Melting point:: 37-42 °C
Boiling point:: 181.5°C (rough estimate)
Density: 1.9318 (rough estimate)
refractive index: 1.6300 (estimate)
Flash point:: 113°
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
pka: -0.91±0.18(Predicted)
form: Low Melting Solid
color: Light yellow to orange
InChI: InChI=1S/C6H5Br2N/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3
InChIKey: WWJLJUAHQHXDGM-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(Br)C(C)=C1
CAS DataBase Reference: 3430-26-0(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-20/21/22-41-37/38-22
Safety Statements: 36/37/39-26-39
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29333999

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 708143
Product name: 2,5-Dibromo-4-methylpyridine
Purity: 97%
Packaging: 1g
Price: $64.7
Updated: 2023/06/20

TCI Chemical

Product number: D4058
Product name: 2,5-Dibromo-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: D4058
Product name: 2,5-Dibromo-4-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TRC

Product number: D425918
Product name: 2,5-Dibromo-4-methylpyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: D425918
Product name: 2,5-Dibromo-4-methylpyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Less

2,5-Dibromo-4-methylpyridine Chemical Properties,Usage,Production

Uses

2,5-Dibromo-4-methylpyridine is mainly used in organic synthesis, and in the pharmaceutical industry, it is used to synthesize heart disease drugs such as disopyramide (disopyramide phosphate). Disopyramide is used to maintain sinus rhythm in atrial fibrillation and atrial flutter, or to prevent the recurrence of ventricular tachycardia and ventricular fibrillation. It can also be used for premature atrial contractions, paroxysmal atrial tachycardia, premature ventricular contractions, etc.

Chemical Properties

Light yellow to orange low melting solid

Synthesis

98198-48-2

3430-26-0

General procedure for the synthesis of 2,5-dibromo-4-methylpyridine from 2-amino-5-bromo-4-methylpyridine: 2-amino-5-bromo-4-methylpyridine (2.0 g, 10.7 mmol) was dissolved in 48% aqueous hydrobromic acid (14 mL, 123 mmol) and cooled to 2 °C in a salt/ice bath. Bromine (1.65 mL, 32.1 mmol) was added dropwise while keeping the internal temperature below 2 °C. Subsequently, a solution of sodium nitrite (3.69 g, 53.5 mmol) in water (5 mL) was added, keeping the internal temperature below 5 °C and the reaction mixture was stirred between 0 °C and 5 °C for 1 hour. The pH of the reaction mixture was adjusted to about 13 by slowly adding and cooling a 50% aqueous sodium hydroxide solution. after warming the reaction mixture to room temperature, it was extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated to give a brown oil. Purification by fast column chromatography on silica gel, using 5% ether/hexane as eluent, afforded the target product 2,5-dibromo-4-methylpyridine as a white solid (1.83 g, 7.29 mmol, 68% yield). Mass spectrometry analysis showed the [M + H]+ peak to be 251.9; the retention time (tR) was 2.3 min (Method 1).

References

[1] Patent: WO2008/124610, 2008, A1. Location in patent: Page/Page column 46
[2] Patent: WO2008/124614, 2008, A1. Location in patent: Page/Page column 38-39

2,5-Dibromo-4-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2,5-Dibromo-4-methylpyridine Suppliers

Americas 1 Belgium 2 China 287 Europe 3 France 2 Germany 6 India 26 Japan 2 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 6 United States 43 Global 382

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

eNovation Chemicals LLC

Tel: --
Fax: --
Email: ales@eNovationChem.com
Country: United States
ProdList: 1673
Advantage: 58

MilliporeSigma (Sigma-Aldrich Corp.)

Tel: --
Fax: --
Email: @sial.com
Country: United States
ProdList: 5414
Advantage: 58

Alichem Inc.

Tel: --
Fax: --
Email: sales@alichem.com
Country: United States
ProdList: 6167
Advantage: 58

AOBChem

Tel: --
Fax: --
Email: sales@aobchem.com
Country: United States
ProdList: 885
Advantage: 58

Combi-Blocks, Inc.

Tel: --
Fax: --
Email: les@combi-blocks.com
Country: United States
ProdList: 2555
Advantage: 58

Redox Scientific

Tel: --
Fax: --
Email: info@redoxsci.com
Country: United States
ProdList: 2380
Advantage: 58

Chemphtec Corporation

Tel: --
Fax: --
Email: fo@chemphtec.com
Country: United States
ProdList: 2181
Advantage: 58

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

SynChem，Inc

Tel: --
Fax: --
Email: sales@synchem.com
Country: United States
ProdList: 4697
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Synthonix

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 1423
Advantage: 68

Reddy Chemtech Inc.

Tel: --
Fax: --
Email: sales@reddychemtech.com
Country: United States
ProdList: 224
Advantage: 0

AOBChem USA

Tel: --
Fax: --
Email: sales@aobchem.com
Country: United States
ProdList: 3487
Advantage: 50

True Pharmachem Inc.

Tel: --
Fax: --
Email: sales@truepharmachem.com
Country: United States
ProdList: 226
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

NOVASYN ORGANICS PVT LTD

Tel: --
Fax: --
Email: info@novasynorganics.com
Country: United States
ProdList: 1316
Advantage: 55

Rintech, Inc.

Tel: --
Fax: --
Email: info@rintechinc.com
Country: United States
ProdList: 3416
Advantage: 60

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

TimTec Corporation

Tel: --
Fax: --
Email: info@timtec.net
Country: United States
ProdList: 6891
Advantage: 68

Asymchem Laboratories, Inc.

Tel: --
Fax: --
Email: info@asymchem.com
Country: United States
ProdList: 1315
Advantage: 69

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Atlantic SciTech Group, Inc.

Tel: --
Fax: --
Email: sales@astginc.com
Country: United States
ProdList: 2308
Advantage: 43

Less

View Lastest Price from 2,5-Dibromo-4-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,5-Dibromo-4-methylpyridine 3430-26-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,5-Dibromo-4-methylpyridine 3430-26-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

Henan Aochuang Chemical Co.,Ltd.

Product: 2,5-Dibromo-4-methylpyridine 3430-26-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

3430-26-0, 2,5-Dibromo-4-methylpyridineRelated Search:

2,5-DIBROMO-3-METHYLPYRIDINE,2,5-DIBROMO-3-METHYLPYRIDINE, PURISS, 98% 2,5-Dibromo-6-methylpyridine 98%,2,5-DIBROMO-6-METHYLPYRIDINE,2,5-Dibromo-6-methylpyridine98% 2,5-Dibromo-3-nitropyridine 3,5-Dibromo-2-methylpyridine 4-AMINO-3,5-DIBROMO-2-METHYLPYRIDINE,4-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 2,6-Dibromopyridine-4-carboxylic acid 2,5-Dibromo-4-methylpyridine 2-Chloro-3,5-dibromo-4-methylpyridine 2,3-DIBROMO-6-METHYLPYRIDINE 2,3-DIBROMO-5-METHYLPYRIDINE 98%,2,3-DIBROMO-5-METHYLPYRIDINE 2-fluoro-3，5-dibromo-4-methylpyridine 2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE,2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 97%,2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE, 97,2-Amino-3,5-dibromo-6-methylpyridine ,98% 2-Amino-3,5-dibromo-4-methylpyridine 3,5-DIBROMO-4-METHYLPYRIDINE 2,5-Dibromopyridine-4-carboxaldehyde 2,5-Dibromo-4-(trifluoromethyl)pyridine 2,5-Dibromo-4-methyl-3-nitropyridine 2,3,5-TRIBROMO-4-METHYLPYRIDINE

TIMTEC-BB SBB003142

2,5-DIBROMO-4-METHYLPYRIDINE

2,5-DIBROMO-4-PICOLINE

2,3-dibromo-4-methylpyridine

2,5-Dibromo-4-picoline,98%

2,5-Dibromo-4-methylpyridine &gt

2,5-Dibromo-4-methyL

Pyridine, 2,5-dibromo-4-methyl-

3-Chloro-3-iodopyridine

2,5-Dibromo-4-methylpyridine ISO 9001：2015 REACH

2,5-Dibromo-4-methylpyridine, 97%

2,5-Dibromo-4-methylpyridine, CAS 3430-26-0

3430-26-0

3430-26-2

C6H5NBr2

Brominated heterocyclic series

Boronic Acid

Pyridine Series

Halides

blocks

Bromides

Pyridines

Pyridine

bc0001