L-KYNURENINE

Product Name: L-KYNURENINE
CAS No.: 2922-83-0
Chemical Name: L-KYNURENINE
Synonyms: CCRIS 4425;L-KYNURENINE;JACS-2922-83-0;(S)-Kynurenine;Kynurenine (L);L-Kynurenine L-Kynurenine Hydrate;L-Kynurenine;L-kynurenine free base;L-KynurenineHydrate>
CBNumber: CB6142966
Molecular Formula: C10H12N2O3
Formula Weight: 208.21
MOL File: 2922-83-0.mol

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L-KYNURENINE Property

Melting point:: 219 °C
Boiling point:: 466.6±45.0 °C(Predicted)
Density: 1.343±0.06 g/cm3(Predicted)
refractive index: -33 ° (C=0.4, H2O)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
pka: 2.21±0.23(Predicted)
form: crystalline
color: light yellow
optical activity: -30.525 (H2O)
Merck: 14,5328
Stability:: Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey: YGPSJZOEDVAXAB-QMMMGPOBSA-N
CAS DataBase Reference: 2922-83-0(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: CY9049700
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: K8625
Product name: L-Kynurenine
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $72.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: K8625
Product name: L-Kynurenine
Purity: ≥98% (HPLC)
Packaging: 1g
Price: $518
Updated: 2024/03/01

TCI Chemical

Product number: K0016
Product name: L-Kynurenine Hydrate
Purity: >98.0%(T)
Packaging: 100mg
Price: $127
Updated: 2024/03/01

Alfa Aesar

Product number: J60199
Product name: L-Kynurenine
Packaging: 50mg
Price: $79.7
Updated: 2024/03/01

Cayman Chemical

Product number: 11305
Product name: Kynurenine
Purity: ≥98%
Packaging: 50mg
Price: $37
Updated: 2024/03/01

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L-KYNURENINE Chemical Properties,Usage,Production

Description

Kynurenine (2922-83-0) is a tryptophan catabolite.1?Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2

Uses

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.

Definition

ChEBI: A kynurenine that has L configuration.

Biochem/physiol Actions

Key intermediate in the breakdown pathway of tryptophan.

storage

Store at RT

References

References/Citations 1) Ibana?et al. (2011),?Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun.,?79?4425 2) Opitz?et al. (2011),?An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature,?478?197

L-KYNURENINE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-KYNURENINE Suppliers

Americas 1 China 180 Europe 1 France 2 Germany 4 India 5 Japan 1 Switzerland 4 United Kingdom 6 United States 28 Global 232

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View Lastest Price from L-KYNURENINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-kynurenine 2922-83-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: L-KYNURENINE 2922-83-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-30

Career Henan Chemical Co

Product: L-KYNURENINE 2922-83-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-30

2922-83-0, L-KYNURENINERelated Search:

3-HYDROXY-L-KYNURENINE 2-(3-INDOLYLMETHYL)-L-TRYPTOPHAN 2-Hydroxy-DL-tryptophan 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-3-CARBOXYLIC ACID HARMANE-1,2,3,4-TETRAHYDRO-3-CARBOXYLIC ACID Tryptophan EP Impurity L Tryptophan EP Impurity F PEAK E Tryptophan EP Impurity D Tryptophan EP Impurity J N'-formyl-L-Kynurenine Dioxindolyl-L-alanine 5-Hydroxytryptophan 3-(phenylamino)alanine D-1,2,3,4-tetrahydronorharmane-3-carboxylic acid N-formylkynurenine H-PHE-TRP-OH L-Isovaline

Tryptophan Impurity 3（Tryptophan EP Impurity C）

JACS-2922-83-0

L-2-AMINO-3-(2-AMINOBENZOYL)PROPIONIC ACID

L-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID

L-KYNURENINE

L-kynurenine free base

β-Anthraniloyl-L-alanine

β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

L-Kynurenine Hydrate

(S)-2-Amino-4-oxo-4-(2-aminophenyl)butanoic acid

(S)-α,2-Diamino-γ-oxobenzenebutanoic acid

3-(2-Aminobenzoyl)alanine

3-(2-Aminobenzoyl)-L-alanine

(2S)-2-amino-4-(2-aminophenyl)-4-keto-butyric acid

(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid

(2S)-2-azanyl-4-(2-azanylphenyl)-4-oxo-butanoic acid

Benzenebutanoic acid, a,2-diaMino-g-oxo-, (aS)-

(S)-2-AMino-4-(2-aMinophenyl)-4-oxobutanoic acid

L-3-(o-Aminobenzoyl)alanine

L-Kynurenine&nbsp

<small>L</small>-Kynurenine Hydrate

L-KYNURENINE, >=98% (HPLC)

Tryptophan EP Impurity C

L-KynurenineHydrate&gt

(S)-Kynurenine

Benzenebutanoic acid, α,2-diamino-γ-oxo-, (αS)-

L-KYNURENINE USP/EP/BP

N-Acetyltryptophan EP Impurity C

Kynurenine (L)

c.?(S)-2-amino-4-(2-aminophenyl)-4-oxobutanoicacid(kynurenine),

L-Kynurenine (Tryptophan Impurity)

CCRIS 4425

Tryptophan - Impurity C

L-Kynurenine, Endogenous AhR agonist

<sc>L</sc>-Kynurenine

2922-83-0

C10H12N2O313H2O

C10H12N2O3xH2O

Amino Acid

BioChemical

Metabolomics

Metabolites and Cofactors on the Metabolic Pathways Chart

Metabolic Pathways

Amino Acids

Biochemistry

non-Proteinorganic Amino Acids