ChemicalBook > CAS DataBase List > 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE

Product Name
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
CAS No.
335165-68-9
Chemical Name
3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
Synonyms
BAX CHANNEL BLOCKER;Bax channel blocke;)-3-(piperazin-1-yL;Baxchannelblocker2HCl;BAI1 (Bax channel blocker);1-(3,6-Dibromo-9H-carbazoL;Bax channel blocker(BAI-1);9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-;1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol;"(+/-)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol"
CBNumber
CB6143286
Molecular Formula
C19H21Br2N3O
Formula Weight
467.2
MOL File
335165-68-9.mol
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3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Property

Boiling point:
388.1±42.0 °C(Predicted)
Density 
1.71±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
form 
solid
pka
14.48±0.20(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64257
Product name
Bax Channel Blocker
Packaging
10mg
Price
$151
Updated
2021/12/16
Tocris
Product number
2160
Product name
Bax Channel Blocker
Purity
≥98%(HPLC)
Packaging
10
Price
$195
Updated
2021/12/16
Tocris
Product number
2160
Product name
Bax Channel Blocker
Purity
≥98%(HPLC)
Packaging
50
Price
$818
Updated
2021/12/16
Usbiological
Product number
254714
Product name
Bax channel blocker
Packaging
10mg
Price
$446
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001067
Product name
BAX CHANNEL BLOCKER
Purity
95.00%
Packaging
5MG
Price
$498.81
Updated
2021/12/16
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3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.

Biological Activity

Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC 50 = 0.52 μ M). Suggested to inhibit Bax channel formation/activity.

in vitro

bax channel blocker, a 3,6-dibromocarbazole derivative, was observed to inhibit cytochrome c releasing from mitochondria by bax channel modulation. the monohydroxy analogue bax channel blocker remained the unprecedented inhibition of bax-induced cytochrome c release at 10 μm. the ic50 value of bax channel blocker was determined to be 0.52 μm, indicating that bax channel blocker was a bax channel inhibitor as hypothesized. moreover, in the liposome assay, bax channel blocker showing significant inhibition (>65%) of cytochrome c release at 10 μm also demonstrated sub-micromolar ic50 value [1].

IC 50

0.52 μm in bax assay

References

[1] bombrun a,gerber p,casi g,terradillos o,antonsson b,halazy s. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via bax channel modulation. j med chem.2003 oct 9;46(21):4365-8.

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Suppliers

VDM Biochemicals
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+1 (866) 333-9607
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EMMX Biotechnology LLC
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TargetMol Chemicals Inc.
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marketing@targetmol.com
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InvivoChem
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Aladdin Scientific
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TargetMol Chemicals Inc.
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ApexBio Technology
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MedChemExpress
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3B Scientific Corporation
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335165-68-9, 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDERelated Search:


  • BAX CHANNEL BLOCKER
  • Baxchannelblocker2HCl
  • 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
  • 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride
  • Bax channel blocke
  • Bax channel blocker(BAI-1)
  • 1-(3,6-Dibromo-9H-carbazoL
  • 9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-
  • )-3-(piperazin-1-yL
  • 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
  • BAI1 (Bax channel blocker)
  • "(+/-)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol"
  • Inhibitor,mitochondrial,cell,inhibit,BAI1,effector,BAI 1,critical,BAX,death,BAI-1,Bcl-2 Family,pathway,Apoptosis
  • 335165-68-9
  • 335165-69-9
  • C19H21Br2N3O2HCl
  • Caspases/Apoptosis
  • Apoptosis Inhibitors