3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE

Product Name: 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
CAS No.: 335165-68-9
Chemical Name: 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE
Synonyms: BAX CHANNEL BLOCKER;Bax channel blocke;)-3-(piperazin-1-yL;BAI1, 10 mM in DMSO;Baxchannelblocker2HCl;BAI1 (Bax channel blocker);1-(3,6-Dibromo-9H-carbazoL;Bax channel blocker(BAI-1);9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-;1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol
CBNumber: CB6143286
Molecular Formula: C19H21Br2N3O
Formula Weight: 467.2
MOL File: 335165-68-9.mol

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3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Property

Boiling point:: 388.1±42.0 °C(Predicted)
Density: 1.71±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: ≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
form: solid
pka: 14.48±0.20(Predicted)
color: White
InChI: InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H
InChIKey: HWFKCAFKXZFOQT-UHFFFAOYSA-N
SMILES: C12=CC=C(Br)C=C1C1=C(C=CC(Br)=C1)N2CC(O)CN1CCNCC1.Cl.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 2160
Product name: Bax Channel Blocker
Purity: ≥98%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

Tocris

Product number: 2160
Product name: Bax Channel Blocker
Purity: ≥98%(HPLC)
Packaging: 50
Price: $818
Updated: 2021/12/16

Usbiological

Product number: 254714
Product name: Bax channel blocker
Packaging: 10mg
Price: $446
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001067
Product name: BAX CHANNEL BLOCKER
Purity: 95.00%
Packaging: 5MG
Price: $498.81
Updated: 2021/12/16

ApexBio Technology

Product number: A4459
Product name: Bax Channel Blocker
Packaging: 10mg
Price: $290
Updated: 2021/12/16

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3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.

Biological Activity

Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC 50 = 0.52 μ M). Suggested to inhibit Bax channel formation/activity.

in vitro

bax channel blocker, a 3,6-dibromocarbazole derivative, was observed to inhibit cytochrome c releasing from mitochondria by bax channel modulation. the monohydroxy analogue bax channel blocker remained the unprecedented inhibition of bax-induced cytochrome c release at 10 μm. the ic50 value of bax channel blocker was determined to be 0.52 μm, indicating that bax channel blocker was a bax channel inhibitor as hypothesized. moreover, in the liposome assay, bax channel blocker showing significant inhibition (>65%) of cytochrome c release at 10 μm also demonstrated sub-micromolar ic50 value [1].

IC 50

0.52 μm in bax assay

References

[1] bombrun a,gerber p,casi g,terradillos o,antonsson b,halazy s. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via bax channel modulation. j med chem.2003 oct 9;46(21):4365-8.

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE Suppliers

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335165-68-9, 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDERelated Search:

Carbazole-9-ethanol 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE 5-Bromo-1-methyl-1H-indole 1-(4-[2-HYDROXY-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPYL]PIPERAZINO)-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPAN-2-OL DIHYDROCHLORIDE 3,6-Dibromo-9-ethylcarbazole 3-Bromo-9H-carbazole 3-(1H-INDOL-1-YL)PROPAN-1-AMINE HYDROCHLORIDE 5-BROMO-1-ETHYL-1H-INDOLE 1-PROPYL-PIPERAZINE MONOHYDROBROMIDE 1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL 1-N-PROPYLPIPERAZINE DIHYDROBROMIDE 3,6-Dibromocarbazole

BAX CHANNEL BLOCKER

Baxchannelblocker2HCl

3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE

3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride

Bax channel blocke

Bax channel blocker(BAI-1)

1-(3,6-Dibromo-9H-carbazoL

9H-Carbazole-9-ethanol, 3,6-dibromo-α-(1-piperazinylmethyl)-

)-3-(piperazin-1-yL

1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol

BAI1 (Bax channel blocker)

"(+/-)-1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol"

Inhibitor,mitochondrial,cell,inhibit,BAI1,effector,BAI 1,critical,BAX,death,BAI-1,Bcl-2 Family,pathway,Apoptosis

BAI1, 10 mM in DMSO

335165-68-9

335165-69-9

C19H21Br2N3O2HCl

Caspases/Apoptosis

Apoptosis Inhibitors