2,2-Dimethylthiopropionamide
- Product Name
- 2,2-Dimethylthiopropionamide
- CAS No.
- 630-22-8
- Chemical Name
- 2,2-Dimethylthiopropionamide
- Synonyms
- NSC 381432;Thiopivalamide;Neopentanethioamide;Dalafenil Impurity 4;2,2-DIMETHYLTHIOPROPIOMIDE;2,2-Trimethylthioacetamide;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;2,2,2-Dimethylthiopropionamide;Propanethioamide, 2,2-dimethyl-
- CBNumber
- CB61449866
- Molecular Formula
- C5H11NS
- Formula Weight
- 117.21
- MOL File
- 630-22-8.mol
2,2-Dimethylthiopropionamide Property
- Melting point:
- 117-119℃ (ethyl acetate hexane )
- Boiling point:
- 162.1±23.0℃ (760 Torr)
- Density
- 0.978±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 51.9±22.6℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate
- form
- Solid
- pka
- 13.33±0.29(Predicted)
- color
- White
- Water Solubility
- Soluble in water (10 g/L) (25°C).
- InChI
- InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7)
- InChIKey
- FJZJUSOFGBXHCV-UHFFFAOYSA-N
- SMILES
- C(N)(=S)C(C)(C)C
Safety
- HS Code
- 2930909899
N-Bromosuccinimide Price
- Product number
- H32092
- Product name
- 2,2,2-Trimethylthioacetamide, 97%
- Packaging
- 1g
- Price
- $53.65
- Updated
- 2024/03/01
- Product number
- H32092
- Product name
- 2,2,2-Trimethylthioacetamide, 97%
- Packaging
- 10g
- Price
- $315.65
- Updated
- 2024/03/01
- Product number
- T796135
- Product name
- 2,2-Dimethylthiopropionamide
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 9562AB
- Product name
- 2,2,2-Trimethylthioacetamide
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- J99033
- Product name
- 2,2,2-Trimethylthioacetamide
- Packaging
- 5g
- Price
- $88
- Updated
- 2021/12/16
2,2-Dimethylthiopropionamide Chemical Properties,Usage,Production
Uses
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
Synthesis
To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).
2,2-Dimethylthiopropionamide Preparation Products And Raw materials
Raw materials
Preparation Products
2,2-Dimethylthiopropionamide Suppliers
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- 44-20819178-90 02081917890
- Fax
- (0)2080432064
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- United Kingdom
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- United Kingdom
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- catalogue@endeavourchem.co.uk
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- United Kingdom
- ProdList
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View Lastest Price from 2,2-Dimethylthiopropionamide manufacturers
- Product
- 2,2-Dimethylpropanethioamide 630-22-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 20000
- Release date
- 2023-12-18
- Product
- 2,2-Dimethylthiopropionamide 630-22-8
- Price
- US $0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.9%
- Supply Ability
- 40-80kgs
- Release date
- 2024-05-24
- Product
- 2,2-Dimethylthiopropionamide 630-22-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- 10mt
- Release date
- 2024-07-29