3-Chloro-4-(3-fluorobenzyloxy)aniline
- Product Name
- 3-Chloro-4-(3-fluorobenzyloxy)aniline
- CAS No.
- 202197-26-0
- Chemical Name
- 3-Chloro-4-(3-fluorobenzyloxy)aniline
- Synonyms
- oxy)aniL;oro-4-(3-fL;LAPATINIB IMP A;Compound PDK0113;Lapatinib impurity A;Lapatinib Impurity 18-d4;3-Chloro-4-((3-fluorobenzyl);Lapatinib genotoxic impurity 1;3-Chloro-4-(3-fluorobenzyloxy)-anilin;4-(3-Fluorobenzyloxy)- 3-chloroaniline
- CBNumber
- CB61456989
- Molecular Formula
- C13H11ClFNO
- Formula Weight
- 251.68
- MOL File
- 202197-26-0.mol
3-Chloro-4-(3-fluorobenzyloxy)aniline Property
- Melting point:
- 78.0 to 82.0 °C
- Boiling point:
- 387.9±32.0 °C(Predicted)
- Density
- 1.306±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol
- form
- powder to crystal
- pka
- 3.98±0.10(Predicted)
- color
- White to Gray to Red
- InChI
- InChI=1S/C13H11ClFNO/c14-12-7-11(16)4-5-13(12)17-8-9-2-1-3-10(15)6-9/h1-7H,8,16H2
- InChIKey
- AYPFEYDGZDPAPE-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(OCC2=CC=CC(F)=C2)C(Cl)=C1
Safety
- RIDADR
- 3077
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29221990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS012378
- Product name
- 3-chloro-4-(3-fluorobenzyloxy)aniline
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $185
- Updated
- 2025/07/31
- Product number
- C2874
- Product name
- 3-Chloro-4-(3-fluorobenzyloxy)aniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- C2874
- Product name
- 3-Chloro-4-(3-fluorobenzyloxy)aniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $146
- Updated
- 2025/07/31
- Product number
- C377650
- Product name
- 3-Chloro-4-(3-fluorobenzyloxy)aniline
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B646
- Product name
- 3-Chloro-4-(3-fluorobenzyloxy)aniline
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
3-Chloro-4-(3-fluorobenzyloxy)aniline Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
3-Chloro-4-(3-fluorobenzyloxy)aniline is an intermediate in the synthesis of Lapatinib (L175800).
Synthesis
443882-99-3
202197-26-0
Example 5: Preparation of 3-chloro-4-(3-fluorobenzyloxy)aniline In a 1 L reactor, 35.6 g of Intermediate-A (3-chloro-4-(3-fluorobenzyloxy)nitrobenzene), 21.2 g of iron powder (70 mesh), and 60.9 g of ammonium chloride were dissolved in a solvent mixture of 506 mL of ethanol and 128 mL of water, and the reaction was carried out at reflux for 2 hours. Upon completion of the reaction, the reaction mixture was cooled to 20-25 °C and the insoluble iron oxide was removed by vacuum filtration. The solid obtained by filtration was washed with ethanol. The filtrates were combined and the solvent was removed by evaporation to give 94.9 g of a highly moist orange solid. The solid was mixed with 400 mL of dichloromethane to dissolve the organic product. The turbid solution was filtered to remove inorganic salts. The filtrate was transferred to a partition funnel to separate the organic phase and remove the aqueous residue. The organic phase was dried over anhydrous sodium sulfate and evaporated to dryness to give 30.8 g of 3-chloro-4-(3-fluorobenzyloxy)aniline (Yield: 96%, Purity as determined by HPLC: 99.67%, Major impurity content: 0.10%).
References
[1] Patent: US2004/53946, 2004, A1
[2] Patent: US2015/366868, 2015, A1. Location in patent: Paragraph 0158
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[4] Patent: WO2009/33581, 2009, A1. Location in patent: Page/Page column 59-60
[5] Patent: WO2009/63054, 2009, A1. Location in patent: Page/Page column 68-69
3-Chloro-4-(3-fluorobenzyloxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-4-(3-fluorobenzyloxy)aniline Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 3-Chloro-4-(3-fluorobenzyloxy)aniline manufacturers
- Product
- Lapatinib Impurity10 202197-26-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 99%+ HPLC
- Supply Ability
- 1000
- Release date
- 2025-06-27
- Product
- 3-Chloro-4-(3-fluorobenzyloxy)aniline 202197-26-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 200kg
- Release date
- 2021-08-25
- Product
- 3-Chloro-4-(3-fluorobenzyloxy)aniline 202197-26-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30