2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

Product Name: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
CAS No.: 898566-17-1
Chemical Name: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
Synonyms: 2-(4-Fluorophenyl)-5-(5-iodo-2-Methylbenzyl)thiophene;2-(4-Fluorophenyl);Canagliflozin INT5;)-5-(5-iodo-2-methyL;Canagliflozin iMpurity D;Kangglinide Intermediate;-5-(5-iodo-2-methylbenzyl);Canagliflozin Intermediate1;2-(4-Fluorophenyl)-5-(5- iodo-methylphenyI) metl;2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]
CBNumber: CB61463466
Molecular Formula: C18H14FIS
Formula Weight: 408.27
MOL File: 898566-17-1.mol

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2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Property

Melting point:: 109-110 °C
Boiling point:: 450.2±45.0 °C(Predicted)
Density: 1.533
vapor pressure: 0-0Pa at 20-25℃
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
color: Pale Yellow
InChI: InChI=1S/C18H14FIS/c1-12-2-7-16(20)10-14(12)11-17-8-9-18(21-17)13-3-5-15(19)6-4-13/h2-10H,11H2,1H3
InChIKey: MGXZKAYHSITHMW-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(F)C=C2)SC(CC2=CC(I)=CC=C2C)=CC=1
LogP: 7.5 at pH7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F532295
Product name: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
Packaging: 250mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Z3520
Product name: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
Packaging: 1g
Price: $33
Updated: 2021/12/16

Matrix Scientific

Product number: 093061
Product name: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
Purity: 95+%
Packaging: 250mg
Price: $439
Updated: 2021/12/16

AK Scientific

Product number: Z3520
Product name: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
Packaging: 100g
Price: $872
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0037557
Product name: 2-(4-FLUOROPHENYL)-5-[(5-IODO-2-METHYLPHENYL)METHYL]THIOPHENE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

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2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid.

Uses

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity.

Synthesis

1030825-20-7

898566-17-1

2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (100 g; cf. WO 2005/012326) was dissolved in toluene (300 mL) at room temperature and under nitrogen atmosphere. To this solution, sodium iodide (83 g), cuprous(I) iodide (2.64 g), N,N'-dimethylethylenediamine (2.94 mL) and diethylene glycol dimethyl ether (50 mL) were added sequentially. The reaction mixture was heated to reflux temperature and stirred continuously for 36 hours. Upon completion of the reaction, ethyl acetate (300 mL) was added to the mixture at 40 °C and filtered through a filter pre-coated with activated carbon. The filtrate was washed and concentrated. The resulting residue was suspended in methanol (426 mL) at reflux temperature for 75 minutes. Subsequently, the suspension was cooled to 25 °C and stirring was continued for 1 hour. The precipitate was collected by filtration, washed with methanol and dried under vacuum at 50 °C to afford 2-(5-iodo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene (94.9 g) in white crystalline form. The mass spectrum (APCI) showed a m/z of 409 (M + H); the melting point was 109-110°C. The crystal was found to have the following properties.

References

[1] Patent: WO2009/35969, 2009, A1. Location in patent: Page/Page column 77
[2] Patent: US2010/99883, 2010, A1. Location in patent: Page/Page column 43
[3] Patent: US2016/228375, 2016, A1. Location in patent: Paragraph 0097; 0098

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Suppliers

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View Lastest Price from 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene manufacturers

Hebei Dangtong Import and export Co LTD

Product: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1
Price: US $100.00-60.00/kg
Min. Order: 100kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

Shaanxi Dideu New Materials Co. Ltd

Product: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 898566-17-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-01

Nanjing Fred Technology Co., Ltd

Product: 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene 898566-17-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

898566-17-1, 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiopheneRelated Search:

Acetonitrile Methanol Methyl acrylate Kresoxim-methyl Thiophene Chlorodimethylphenylsilane Methylparaben Silicone oil (high temperature) Basic Violet 1 Tri(o-tolyl)phosphine 1,2,3-Triacetyl-5-deoxy-D-ribose 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone LIPOPHILIC SEPHADEX 2-(4-Fluorophenyl)-thiophene Canagliflozin 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine Methyl BCP19353

Thiophene, 2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]-

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

2-(4-Fluorophenyl)-5-(5-iodo-2-Methylbenzyl)thiophene

Canagliflozin iMpurity D

2-((5-IODO-2-METHYLPHENYL)METHYL)-5-(4-FLUOROPHENYL)THIOPHENE

Canagliflozin INT5

Canagliflozin Intermediate1

2-(4-Fluorophenyl)

-5-(5-iodo-2-methylbenzyl)

2-(4-Flurophenyl)-5-[(5-Iodo-2-methylphenyl] methyl] Thiophene

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]

)-5-(5-iodo-2-methyL

2-(4-FLUOROPHENYL)-5-[(5-IODO-2-METHYLPHENYL)METHYL]THIOPHENE 898566-17-1

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene ISO 9001：2015 REACH

Canagliflozin intermediates，2-(4-Fluorophenyl)-5-[(5-iodo-2- methylphenyl)methyl]thiophene

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene cas 898566-17-1

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophen...

Canagliflozin impurity DQ: What is Canagliflozin impurity D Q: What is the CAS Number of Canagliflozin impurity D Q: What is the storage condition of Canagliflozin impurity D

2-(4-Fluorophenyl)-5-(5-iodo-methylphenyl) methyl] thiophene

2-(4-Fluorophenyl)-5-(5- iodo-methylphenyI) metl

2-(4-Fluoropheny1)-5-[(5-iodo-2 methylphenyl)methyl]thiophene

Canagliflozin impurity-(2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

Kangglinide Intermediate

2-(5-iodo-2-methylbenzyl)-5-(4-fluoro-phe?nyl)thiophene

898566-17-1

C18H14FIS

C18H14FI

898566-17-1