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Coronarin A

Product Name
Coronarin A
CAS No.
119188-33-9
Chemical Name
Coronarin A
Synonyms
Coronarin A;(2S,4R,4aS,8aS)-4-[(E)-2-(3-Furyl)vinyl]-4a,8,8-trimethyl-3-methylenedecahydro-2-naphthalenol;2-Naphthalenol, 4-[(1E)-2-(3-furanyl)ethenyl]decahydro-4a,8,8-trimethyl-3-methylene-, (2S,4R,4aS,8aS)-
CBNumber
CB61469842
Molecular Formula
C20H28O2
Formula Weight
300.44
MOL File
119188-33-9.mol
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Coronarin A Property

form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
CFN99301
Product name
CoronarinA
Purity
≥98%
Packaging
5mg
Price
$553
Updated
2021/12/16
Crysdot
Product number
CD32002740
Product name
CoronarinA
Purity
95+%
Packaging
5mg
Price
$860
Updated
2021/12/16
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Coronarin A Chemical Properties,Usage,Production

Uses

Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].

in vivo

Coronarin A (30 or 100 mg/kg; i.p. or p.o.; once daily for 22 days) ameliorates hyperglycemia in mice[1].
Coronarin A (100 mg/kg; p.o.; once daily for 22 days) inhibits the mTOR/S6K1 pathway to activate PI3K/Akt and ERK/β-catenin signaling in livers of ob/ob mice[1].
Pharmacokinetic properties of Coronarin A after single administrationa in ob/ob mice[1].

Coronarin At1/2 (h)tmax (h)Cmax (ng/mL)AUC0-t (ng·h/mL)AUC0-∞ (ng·h/mL)MRT (h)
i.p.14.81.0107345711104521.7
p.o.3.011.0388169418564.88

Data are presented as the mean of three mice.
aCoronarin A was intraperitoneally or orally administered at 30 mg/kg to ob/ob mice.
Animal Model:Male ob/ob mice[1]
Dosage:30 mg/kg (IP) or 100 mg/kg (PO)
Administration:Oral or intraperitoneal administration, once daily for 22 days
Result:Significantly decreased the non-fasting and fasting blood glucose. Significantly reduced the serum insulin concentration at 15 min after glucose loading, reduced the average daily food intake while the body weight was unaffected. Increased hepatic glycogen content and the expression levels of gluconeogenic gene Pck1 and G6pc were significantly decreased.
Animal Model:Female ob/ob mice[1]
Dosage:30 mg/kg
Administration:Intraperitoneal or oral administration (Pharmacokinetic Analysis)
Result:Intraperitoneal injection exhibited higher plasma exposure than oral gavage at the same dose of 30 mg/kg, with Cmax value of 1073 and 388 ng/mL, respectively.

IC 50

mTORC1; S6K1

References

[1] Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9. DOI:10.1038/s41401-022-00985-5

Coronarin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Coronarin A Suppliers

China 44 United States 5 Global 49
Chembest Research Laboratories Limited
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Shanghai ChengShao Biological Technology Co., Ltd.
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Shanghai Jizhi Biochemical Technology Co. Ltd.
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119188-33-9, Coronarin ARelated Search:

2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Artemether hydroxygenkwanin alpha-Terpineol beta-Sitosterol Hydroxyecdysone alpha-Cyperone beta-Eudesmol MOSLOFLAVONE

  • Coronarin A
  • 2-Naphthalenol, 4-[(1E)-2-(3-furanyl)ethenyl]decahydro-4a,8,8-trimethyl-3-methylene-, (2S,4R,4aS,8aS)-
  • (2S,4R,4aS,8aS)-4-[(E)-2-(3-Furyl)vinyl]-4a,8,8-trimethyl-3-methylenedecahydro-2-naphthalenol
  • 119188-33-9