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Fargesone A

Product Name
Fargesone A
CAS No.
116424-69-2
Chemical Name
Fargesone A
Synonyms
Fargesone A;(2S,3R,3aR,7S,7aS)-2-(1,3-benzodioxol-5-yl)-3a,4-dimethoxy-3-methyl-7-prop-2-enyl-2,3,7,7a-tetrahydro-1-benzofuran-6-one;6(2H)-Benzofuranone, 2-(1,3-benzodioxol-5-yl)-3,3a,7,7a-tetrahydro-3a,4-dimethoxy-3-methyl-7-(2-propen-1-yl)-, (2R,3S,3aS,7S,7aR)-;[2R-(2alpha,3beta,3abeta,7alpha,7abeta)]-2-(1,3-Benzodioxol-5-yl)-3,3a,7,7a-tetrahydro-3a,4-dimethoxy-3-methyl-7-(2-propenyl)-6(2H)-benzofuranone
CBNumber
CB61470473
Molecular Formula
C21H24O6
Formula Weight
372.41
MOL File
116424-69-2.mol
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Fargesone A Property

Boiling point:
508.0±50.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
CFN96245
Product name
FargesoneA
Purity
≥98%
Packaging
5mg
Price
$463
Updated
2021/12/16
Crysdot
Product number
CD32002782
Product name
FargesoneA
Purity
95+%
Packaging
5mg
Price
$730
Updated
2021/12/16
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Fargesone A Chemical Properties,Usage,Production

Uses

Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity[1].

Definition

ChEBI: Fargesone A is a member of benzodioxoles.

in vivo

Fargesone A (3 and 30 mg/kg; i.p.; daily for 7 days) significantly ameliorates pathological features in bile duct ligation (BDL)-induced chronic liver fibrosis mouse model[1].
Pharmacokinetics parameters of Fargesone A in mice

t1/2 (h)Tmax (h)Cmax (ng/mL)AUC0-t (ng/mL*h)AUC0-inf (ng/mL*h)MRT0-inf (h)F (%)
i.v. (5 mpk)0.68±0.1-941±57469±13471±140.43±0.13-
p.o. (10 mpk)0.33±0.040.25±0.00104±16101±32102±320.58±0.0710.8±3.2
Animal Model:C57BL/6 mice, bile duct ligation (BDL)-induced chronic liver fibrosis mouse model[1]
Dosage:3 and 30 mg/kg
Administration:IP, once daily for 7 days
Result:Resulted in a lower level of inflammatory infiltrates and a smaller amount of collagen deposition compared to the vehicle group. Reversed BDL-induced sharp increase in total bilirubin level in the serum. Significantly decreased liver mRNA expression of the inflammatory biomarkers interleukin (IL)-6, IL-1β, inducible nitric oxide synthase (iNOS), and prostaglandin-endoperoxide synthase 2 (COX2).
Animal Model:C57BL6/J mice[1]
Dosage:5 or 10 mg/kg
Administration:IV or PO (Pharmacokinetics Analysis)
Result:Showed acceptable PK profiles in general.

References

[1] Guo F, et al. Biomimetic Total Synthesis and the Biological Evaluation of Natural Product (-)-Fargesone A as a Novel FXR Agonist. JACS Au. 2022 Dec 7;2(12):2830-2838. DOI:10.1021/jacsau.2c00600

Fargesone A Preparation Products And Raw materials

Raw materials

Preparation Products

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Fargesone A Suppliers

China 34 United States 4 Global 38
BioBioPha Co., Ltd.
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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Wuhan ChemFaces Biochemical Co., Ltd.
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116424-69-2, Fargesone ARelated Search:

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  • Fargesone A
  • [2R-(2alpha,3beta,3abeta,7alpha,7abeta)]-2-(1,3-Benzodioxol-5-yl)-3,3a,7,7a-tetrahydro-3a,4-dimethoxy-3-methyl-7-(2-propenyl)-6(2H)-benzofuranone
  • 6(2H)-Benzofuranone, 2-(1,3-benzodioxol-5-yl)-3,3a,7,7a-tetrahydro-3a,4-dimethoxy-3-methyl-7-(2-propen-1-yl)-, (2R,3S,3aS,7S,7aR)-
  • (2S,3R,3aR,7S,7aS)-2-(1,3-benzodioxol-5-yl)-3a,4-dimethoxy-3-methyl-7-prop-2-enyl-2,3,7,7a-tetrahydro-1-benzofuran-6-one
  • 116424-69-2