2-Bromo-5-chloro-4-fluoroaniline

Product Name: 2-Bromo-5-chloro-4-fluoroaniline
CAS No.: 85462-59-5
Chemical Name: 2-Bromo-5-chloro-4-fluoroaniline
Synonyms: BroMo-5-chloro-4-fluoroaniline;2-Bromo-4-fluoro-5-chloroaniline;2-BROMO-5-CHLORO-4-FLUOROANILINE;3-broMo-5-chloro-2-fluorobenzenaMine;2-bromo-5-chloro-4-fluorobenzenamine;Benzenamine, 2-bromo-5-chloro-4-fluoro-;1-Amino-2-bromo-5-chloro-4-fluorobenzene
CBNumber: CB61476172
Molecular Formula: C6H4BrClFN
Formula Weight: 224.46
MOL File: 85462-59-5.mol

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2-Bromo-5-chloro-4-fluoroaniline Property

Melting point:: 75-79°
Boiling point:: 272.5±35.0 °C(Predicted)
Density: 1.809±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.54±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B415775
Product name: 2-Bromo-5-chloro-4-fluoroaniline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B415775
Product name: 2-Bromo-5-chloro-4-fluoroaniline
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: Y4290
Product name: 2-Bromo-5-chloro-4-fluorobenzenamine
Packaging: 2g
Price: $137
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3630-F-02
Product name: 2-Bromo-5-chloro-4-fluoroaniline
Packaging: 5G
Price: $144
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB12559
Product name: 2-Bromo-5-chloro-4-fluoroaniline
Packaging: 10g
Price: $180
Updated: 2021/12/16

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2-Bromo-5-chloro-4-fluoroaniline Chemical Properties,Usage,Production

Synthesis

367-21-5

85462-59-5

General procedure for the synthesis of 2-bromo-4-fluoro-5-chloroaniline from 3-chloro-4-fluoroaniline: to a solution of 3-chloro-4-fluoroaniline (5 g, 34.3 mmol) in dichloromethane (60 mL) under ice-bath cooling conditions was added pyridine (4.2 ml, 51.5 mmol), and bromine (1.8 ml, 34.3 mmol) was added slowly and dropwise to a dichloromethane ( 40mL) solution. The reaction mixture was stirred continuously for 1 hour under an ice bath. Upon completion of the reaction, the reaction was quenched by adding aqueous sodium thiosulfate to the mixture and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford the target product 2-bromo-4-fluoro-5-chloroaniline (6.4 g, yield: 83%) as an orange solid. m/z = 223 [M + H]+ by LC-MS.

References

[1] Patent: EP3112369, 2017, A1. Location in patent: Paragraph 0296; 0297
[2] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0196
[3] Tetrahedron Letters, 2002, vol. 43, # 42, p. 7581 - 7583
[4] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 179 - 195

2-Bromo-5-chloro-4-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-chloro-4-fluoroaniline Suppliers

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85462-59-5