5-Chloro-1-methyl-4-nitroimidazole
Description References- Product Name
- 5-Chloro-1-methyl-4-nitroimidazole
- CAS No.
- 4897-25-0
- Chemical Name
- 5-Chloro-1-methyl-4-nitroimidazole
- Synonyms
- 5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE;CMNI;pcmni;NSC-7852;S-50154-9;A(S50154-9);AZATHIOPRINUM;TIMTEC-BB SBB003949;Azathioprine Impurity 9;Azathioprine EP Impurity C
- CBNumber
- CB6151649
- Molecular Formula
- C4H4ClN3O2
- Formula Weight
- 161.55
- MOL File
- 4897-25-0.mol
5-Chloro-1-methyl-4-nitroimidazole Property
- Melting point:
- 148-150 °C (lit.)
- Boiling point:
- 362.3±22.0 °C(Predicted)
- Density
- 1.9518 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -1.37±0.61(Predicted)
- form
- Powder
- color
- White
- InChIKey
- OSJUNMSWBBOTQU-UHFFFAOYSA-N
- CAS DataBase Reference
- 4897-25-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-imidazole, 5-chloro-1-methyl-4-nitro-(4897-25-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- NI4397100
- HazardClass
- IRRITANT
- HS Code
- 29332900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 367532
- Product name
- 5-Chloro-1-methyl-4-nitroimidazole
- Purity
- 98%
- Packaging
- 5g
- Price
- $138
- Updated
- 2024/03/01
- Product number
- C1646
- Product name
- 5-Chloro-1-methyl-4-nitroimidazole
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $84
- Updated
- 2024/03/01
- Product number
- H61824
- Product name
- 5-Chloro-1-methyl-4-nitroimidazole, 95%
- Packaging
- 1g
- Price
- $33.9
- Updated
- 2023/06/20
- Product number
- H61824
- Product name
- 5-Chloro-1-methyl-4-nitroimidazole, 95%
- Packaging
- 5g
- Price
- $115
- Updated
- 2023/06/20
- Product number
- C369270
- Product name
- 5-Chloro-1-methyl-4-nitroimidazole
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
5-Chloro-1-methyl-4-nitroimidazole Chemical Properties,Usage,Production
Description
5-Chloro-1-methyl-4-nitroimidazole is an imidazole derivative. It is useful in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells. It can also be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine) palladium (II), K2CO3 and tetrabutylammonium bromide.
References
http://www.sigmaaldrich.com/catalog/product/aldrich/367532?lang=en®ion=US
Watts, M. E., et al. "Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole." Int J Radiat Biol Relat Stud Phys Chem Med 38.6(1980):673-675.
Saadeh, H. A, I. M. Mosleh, and M. M. Elabadelah. "New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. "Molecules 14.8(2009):2758-67.
Description
5-Chloro-1-methyl-4-nitroimidazole is an intermediate in azathioprine synthesis, also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross reactivity is possible with imidazoles tioconazole, and econazole.
Chemical Properties
White Solid
Uses
5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.
General Description
5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.
Contact allergens
This intermediate in azathioprine synthesis is also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross-reactivity is possible with imidazoles tioconazole and econazole.
5-Chloro-1-methyl-4-nitroimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloro-1-methyl-4-nitroimidazole manufacturers
- Product
- 5-Chloro-1-methyl-4-nitroimidazole 4897-25-0
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08
- Product
- 5-Chloro-1-methyl-4-nitroimidazole 4897-25-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 5-Chloro-1-methyl-4-nitroimidazole 4897-25-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20