Otenabant
- Product Name
- Otenabant
- CAS No.
- 686344-29-6
- Chemical Name
- Otenabant
- Synonyms
- CS-1072;otenabant;Otenabant, >=98%;CP945598 free base;Otenabant (CP-945,598);Otenabant, 10 mM in DMSO;CP 945598;OTENABANT;CP945598;CP 945598; CP-945598; CP945598;Otenabant (CP-945598 free base);1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide
- CBNumber
- CB61518526
- Molecular Formula
- C25H25Cl2N7O
- Formula Weight
- 510.42
- MOL File
- 686344-29-6.mol
Otenabant Property
- Boiling point:
- 757.9±70.0 °C(Predicted)
- Density
- 1.46
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (195.92 mM; Need ultrasonic)
- form
- Powder
- pka
- 16.30±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-1279
- Product name
- Otenabant
- Purity
- 99.33%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-1279
- Product name
- Otenabant
- Purity
- 99.33%
- Packaging
- 10mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- A3691
- Product name
- Otenabant
- Packaging
- 10mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- API0006009
- Product name
- CP-945598
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $305.55
- Updated
- 2021/12/16
- Product number
- CS-1279
- Product name
- Otenabant
- Purity
- 99.33%
- Packaging
- 50mg
- Price
- $396
- Updated
- 2021/12/16
Otenabant Chemical Properties,Usage,Production
Uses
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.
Biological Activity
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with a Ki of 0.7 nM, more than 1000-fold selective for CB2.
in vitro
Otenabant HCl has low affinity with K i of 7.6 μM for human CB2 receptors. It inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration. < /p>
in vivo
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. It (10 mg/kg, po) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. And Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.
target
Ki: 0.7 nM (CB1)
References
[1] John R. Hadcock, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochemical and Biophysical Research Communications, 2010; 394;366-371.
[2] Griffith DA, et al. Discovery of 1-[9-(4-chlorophenyl) -8-(2-chlorophenyl)- 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. JMedChem. 2009 ;5
Otenabant Preparation Products And Raw materials
Raw materials
Preparation Products
Otenabant Suppliers
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- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
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- 2922
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- +86-27-87599188
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- 021-58950125
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- (86) 21-58955996
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- China
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- 400-6206333 13167063860
- Fax
- 021-50323701
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- China
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- 25683
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- 021-18621020637 18621020637
- sales@sunsynpharma.com
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- China
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- 025-58849295 18951903616;
- Fax
- 025-68650336
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- China
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- +86-21-5821 5861
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- +86-21-5106 2861
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- China
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- +86-21-58447131
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- +86-21-61642470
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- China
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- 15261860116
- Fax
- 86-025-84106591
- sales@elsa-biotech.com
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- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
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View Lastest Price from Otenabant manufacturers
- Product
- Otenabant 686344-29-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Otenabant 686344-29-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08