Otenabant

ChemicalBook > CAS DataBase List > Otenabant

Product Name: Otenabant
CAS No.: 686344-29-6
Chemical Name: Otenabant
Synonyms: CS-1072;otenabant;Otenabant, >=98%;CP945598 free base;Otenabant (CP-945,598);CP 945598;OTENABANT;CP945598;CP 945598; CP-945598; CP945598;Otenabant (CP-945598 free base);1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide;4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-
CBNumber: CB61518526
Molecular Formula: C25H25Cl2N7O
Formula Weight: 510.42
MOL File: 686344-29-6.mol

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Otenabant Property

Boiling point:: 757.9±70.0 °C(Predicted)
Density: 1.46
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (195.92 mM; Need ultrasonic)
form: Powder
pka: 16.30±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1279
Product name: Otenabant
Purity: 99.33%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-1279
Product name: Otenabant
Purity: 99.33%
Packaging: 10mg
Price: $119
Updated: 2021/12/16

ApexBio Technology

Product number: A3691
Product name: Otenabant
Packaging: 10mg
Price: $156
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006009
Product name: CP-945598
Purity: 95.00%
Packaging: 10MG
Price: $305.55
Updated: 2021/12/16

ChemScene

Product number: CS-1279
Product name: Otenabant
Purity: 99.33%
Packaging: 50mg
Price: $396
Updated: 2021/12/16

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Otenabant Chemical Properties,Usage,Production

Biological Activity

Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with a Ki of 0.7 nM, more than 1000-fold selective for CB2.

in vitro

Otenabant HCl has low affinity with K _i of 7.6 μM for human CB2 receptors. It inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration. < /p>

in vivo

Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. It (10 mg/kg, po) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. And Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.

target

Ki: 0.7 nM (CB1)

Otenabant Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Otenabant manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Otenabant 686344-29-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Otenabant 686344-29-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

686344-29-6, OtenabantRelated Search:

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otenabant

1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide

Otenabant (CP-945,598)

Otenabant, >=98%

CP945598 free base

Otenabant (CP-945598 free base)

CS-1072

CP 945598; CP-945598; CP945598

CP 945598;OTENABANT;CP945598

4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-

686344-29-6

C25H25Cl2N7O