ChemicalBook > CAS DataBase List > 1,2-Bis(chlorodimethylsilyl)ethane

1,2-Bis(chlorodimethylsilyl)ethane

Product Name
1,2-Bis(chlorodimethylsilyl)ethane
CAS No.
13528-93-3
Chemical Name
1,2-Bis(chlorodimethylsilyl)ethane
Synonyms
1,2-Bis(chlorodimethylsilyl);1,1,4,4-TETRAMETHYL-1,4-DICHLORODISILYLETHYLENE;chloro[2-(chlorodimethylsilyl)ethyl]dimethylsilane;DK065;DK525;STABASE;SILANE BM2E;[-CH2Si(CH3)2Cl]2;Patchouli oil 8014-09-3;1,2-Bis(dimethylchlorosily)ethane
CBNumber
CB6154680
Molecular Formula
C6H16Cl2Si2
Formula Weight
215.27
MOL File
13528-93-3.mol
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1,2-Bis(chlorodimethylsilyl)ethane Property

Melting point:
35-38 °C (lit.)
Boiling point:
198 °C/734 mmHg (lit.)
Density 
0.99
Flash point:
155 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Low Melting Solid
color 
Transparent
Water Solubility 
Reacts with water.
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN 
1920141
InChIKey
VGQOKOYKFDUPPJ-UHFFFAOYSA-N
CAS DataBase Reference
13528-93-3(CAS DataBase Reference)
EPA Substance Registry System
Silane, 1,2-ethanediylbis[chlorodimethyl- (13528-93-3)
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Safety

Hazard Codes 
C
Risk Statements 
34-10
Safety Statements 
26-28-36/37/39-45-16
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
10-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29319000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
267880
Product name
1,2-Bis(chlorodimethylsilyl)ethane
Purity
96%
Packaging
25g
Price
$99.6
Updated
2024/03/01
TCI Chemical
Product number
B1688
Product name
1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]
Purity
>95.0%(GC)
Packaging
5g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
B1688
Product name
1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]
Purity
>95.0%(GC)
Packaging
25g
Price
$185
Updated
2024/03/01
Alfa Aesar
Product number
L02570
Product name
1,2-Bis(chlorodimethylsilyl)ethane, tech. 90%
Packaging
25g
Price
$55.65
Updated
2024/03/01
Alfa Aesar
Product number
L02570
Product name
1,2-Bis(chlorodimethylsilyl)ethane, tech. 90%
Packaging
100g
Price
$202
Updated
2024/03/01
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1,2-Bis(chlorodimethylsilyl)ethane Chemical Properties,Usage,Production

Chemical Properties

transparent low melting solid

Physical properties

mp 36–41°C; bp 198°C/734 mmHg.

Uses

1,2-Bis(chlorodimethylsilyl)ethane is used as Protecting Reagent for Primary Amines. It is also used in Medicine field, electronics industry and polymer material.

Uses

1,2-Bis(chlorodimethylsilyl)ethane can be used as a reagent for the protection of primary amines as their tetramethyldisilylazacyclopentane or Stabase adducts; used in combination with zinc to form organozinc carbenoids; electrophilic silylating reagent.
Protection of Primary Amines.
Few protecting groups exist for the N,N-diprotection of primary amines. The tetramethyldisilylazacyclopentane or Stabase adduct (3) is particularly attractive for this purpose due to its ease of preparation, base stability and facile removal. This cyclic disilane is easily prepared (eq 1) from the commercially available title reagent (1).For primary amines with pKa values between 10 and 11, typical reaction conditions involve the treatment of a dichloromethane solution of the amine with (1) in the presence of two equivalents of triethylamine at room temperature. Subsequent workup with aqueous dihydrogen phosphate provides (3) in excellent yields.1 Stabase adducts are quite stable to strongly basic conditions such as n-butyllithium and s-butyllithium (at ?25°C), lithium diisopropylamide, and Grignard reagents making it a superb candidate for use in the alkylation of substrates bearing a primary amine. For example, protected amino acid derivatives are easily alkylated (eq 2).After formation of the lithium enolate of the protected ethyl glycinate (4) under standard conditions, exposure to various alkyl halides or aldehydes yields alkylation products such as (5).

1,2-Bis(chlorodimethylsilyl)ethane Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-Bis(chlorodimethylsilyl)ethane Suppliers

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View Lastest Price from 1,2-Bis(chlorodimethylsilyl)ethane manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1,2-Bis(chlorodimethylsilyl)ethane 96% 13528-93-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
1,2-Bis(chlorodimethylsilyl)ethane 13528-93-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

13528-93-3, 1,2-Bis(chlorodimethylsilyl)ethaneRelated Search:

1,1,2,2-Tetrachloroethane Isobutylene oxide DIMETHYLTHEXYLSILYL CHLORIDE CHLORODIMETHYLVINYLSILANE CHLOROETHANE ETHANE tert-Butyldimethylsilyl chloride Hexafluoroethane POLYDIMETHYLSILOXANE 1-Cyclohexenyloxytrimethylsilane (2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE Chlorodimethylsilane ETHYLDIMETHYLSILANE Chlorotrimethylsilane TRIMETHYLSILANE ETHYLDIMETHYLCHLOROSILANE DISILANE METHYLETHYLCHLOROSILANE

  • 1,2-Bis(chlorodimethylsily)ethane
  • 1,2-ethanediylbis[chlorodimethyl-silan
  • 1,2-Bis(chlorodimethylsilyl)ethane,96%
  • [-CH2Si(CH3)2Cl]2
  • 1,2-Bis(dimethylchlorosily)ethane
  • Tetra-Methyl-Di-Chloro-Ethyl-Di-SilaneOR1,2-Bis(chlorodimethylsilyl)ethane
  • [Protecting Reagent for PriMary AMines]
  • 1,2-Bis(chlorodiMethylsilyl)ethane&nbsp
  • 1,2-Bis(chlorodiMethylsilyl)ethane, 96% 25GR
  • 1,2-Bis(chlorodiMethylsilyl)ethane, 96% 5GR
  • 1,2-Bis(chlorodimethylsilyl)
  • chloro[2-(chlorodimethylsilyl)ethyl]dimethylsilane
  • 1,2-Bis(chlorodiMethylsilyl)ethane 96%
  • 1,2-Bis(chlorodimethylsilyl)ethane(1,1,4,4-Tetramethyl-1,4-dichlorodisilethylene)
  • 1,1,4,4-Tetramethyl-1,4-dichloro-disilethylene, 2,5-Dichloro-2,5-dimethyl-2,5-disilahexane
  • 1,2-ethanediylbis[chlorodimethyl-Silane
  • SILANE BM2E
  • STABASE
  • 1,2-BIS(CHLORODIMETHYLSILYL)ETHANE
  • 1,2-BIS(DIMETHYLCHLOROSILYL)ETHANE
  • 1,1,4,4-TETRAMETHYL-1,4-DICHLORODISILETHYLENE
  • 1,1,4,4-TETRAMETHYL-1,4-DICHLORODISILYLETHYLENE
  • 1,1,4,4-TETRAMETHYL-1,4-DICHLORO-DISYLETHYLENE
  • 2,5-DICHLORO-2,5-DIMETHYL-2,5-DISILAHEXANE
  • ethylenebis[chlorodimethylsilane]
  • 1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]
  • 1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]&gt
  • Silane, 1,1'-(1,2-ethanediyl)bis[1-chloro-1,1-dimethyl-
  • Patchouli oil 8014-09-3
  • 1,1'-(1,2-Ethanediyl)bis[1-chloro-1,1-dimethylsilane
  • DK065
  • DK525
  • 1,1'-(1,2-Ethanediyl)bis[1-chloro-1,1-dimethylsilane
  • 13528-93-3
  • -CH2SiCH32Cl2
  • C6H16Cl2Si2
  • Protection and Derivatization
  • Protecting and Derivatizing Reagents
  • Silicon-Based
  • Synthetic Reagents
  • Monochlorosilanes
  • Si-Cl Compounds
  • Si (Classes of Silicon Compounds)
  • Protection & Derivatization Reagents (for Synthesis)
  • Silicon Compounds (for Synthesis)
  • Monochlorosilanes
  • Protection & Derivatization Reagents (for Synthesis)
  • Si (Classes of Silicon Compounds)
  • Si-Cl Compounds
  • Silicon Compounds (for Synthesis)
  • Synthetic Organic Chemistry