ChemicalBook > CAS DataBase List > 1-(2,6-dichloropyridin-3-yl)ethanone

1-(2,6-dichloropyridin-3-yl)ethanone

Product Name
1-(2,6-dichloropyridin-3-yl)ethanone
CAS No.
412018-50-9
Chemical Name
1-(2,6-dichloropyridin-3-yl)ethanone
Synonyms
1-(2,6-Dichloropyridin-3-yl);3-Acetyl-2,6-dichloropyridine;1-(2,6-Dichloro-3-pyridyl)ethanone;1-(2,6-dichloropyridin-3-yl)ethanone;1-(2,6-Dichloro-3-pyridinyl)-ethanone;ETHANONE, 1-(2,6-DICHLORO-3-PYRIDINYL)-;1-(2,6-dichloropyridin-3-yl)ethan-1-one
CBNumber
CB61555446
Molecular Formula
C7H5Cl2NO
Formula Weight
190.03
MOL File
412018-50-9.mol
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1-(2,6-dichloropyridin-3-yl)ethanone Property

Boiling point:
286.7±35.0 °C(Predicted)
Density 
1.376±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-4.81±0.10(Predicted)
Appearance
Off-white to yellow Solid-liquid mixture
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D438365
Product name
1-(2,6-Dichloropyridin-3-yl)ethanone
Packaging
500mg
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD144036
Product name
1-(2,6-Dichloropyridin-3-yl)ethanone
Packaging
250mg
Price
$82.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD144036
Product name
1-(2,6-Dichloropyridin-3-yl)ethanone
Packaging
500mg
Price
$145
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD144036
Product name
1-(2,6-Dichloropyridin-3-yl)ethanone
Packaging
1g
Price
$252
Updated
2021/12/16
Matrix Scientific
Product number
070781
Product name
1-(2,6-Dichloropyridin-3-yl)ethan-1-one
Purity
97%
Packaging
500mg
Price
$390
Updated
2021/12/16
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1-(2,6-dichloropyridin-3-yl)ethanone Chemical Properties,Usage,Production

Synthesis

917-64-6

873936-98-2

412018-50-9

To a solution of 2,6-dichloro-N-methoxy-N-methylnicotinamide (487 mg) obtained in step (1) in tetrahydrofuran (10 mL) was slowly added methylmagnesium iodide (1.24 mL, 2M ethyl ether solution) at 0 °C. The reaction mixture was then warmed to 70 °C with continuous stirring for 72 hours. Upon completion of the reaction, the reaction was quenched by adding saturated aqueous ammonium chloride solution to the mixture and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography to give the final 2,6-dichloro-3-acetylpyridine (205 mg) as a colorless oil. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 7.93 (1H, d, J = 8.1 Hz), 7.37 (1H, d, J = 8.1 Hz), 2.71 (3H, s). ESI-MS analysis showed a molecular ion peak of 190 [M + H]+.

References

[1] Patent: EP2669270, 2013, A1. Location in patent: Paragraph 0880-0882
[2] Patent: EP2878594, 2015, A1. Location in patent: Paragraph 0873; 0874
[3] Patent: WO2016/57834, 2016, A1. Location in patent: Paragraph 000591; 000601

1-(2,6-dichloropyridin-3-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2,6-dichloropyridin-3-yl)ethanone manufacturers

Shanghai Rlavie Technology Co ltd
Product
3-Acetyl-2,6-dichloropyridine 412018-50-9
Price
US $0.00-0.00/kg
Min. Order
0.0001kg
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-10